Posted by admin on Dec 1, 2013 in |
Salbutamol sulphate (SS) loaded microspheres were prepared by solvent evaporation method with combination of Sterculia foetida gum in various proportions. A total of eighteen formulations were prepared in different oil phases i.e., liquid paraffin and sunflower oil. Those prepared from liquid paraffin L1-L9 and those prepared from sunflower oil were S1-S9. Based on the particle size, entrapment efficiency, drug content,% yield, swelling index, % moisture loss, micromeritic properties batches prepared from sunflower oil showed better results as compared to those microspheres prepared from liquid paraffin. Thus, sunflower oil batches were optimized for further evaluation parameters. From further parameters four formulations were selected i.e., S2, S6, S8, S9. It was confirmed with the results of micromeritic property that all the selected formulations showed good flow property. Release data were analyzed based on best fitting models and all the optimized batches showed good fit to first order, Higuchi kinetics and Korsemeyer-Peppas. Stability studies showed almost negligible changes in particle size, drug content and drug release throughout the study ...
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Posted by admin on Dec 1, 2013 in |
The whole plant of Spermacoce hispida L is reported to have great medicinal value.It is found effective systemically in treating, headache, constipation, anti-hypertensive, anti-fertility, Appetite, Scabies, Irritant bowel syndrome and skin disease etc. Intake of 2 to 4 g of the seeds along with a mixture of dry ginger, coriander seed andfinger millet reduces the unwanted cholesterol namely LDL and HDL from the body. Traditionally roots, leaves and stem of the Spermacoce hispida L are used as anti-eczema, antibacterial and cardio-vascular disorder, etc. Recently it is found that this herb contains Calcium and Phosphorus in the abundance hence administration of this drug in form of chooranam or kudineer (decoction) is recommended in conditions like bone diseases, fractures etc The present investigation was therefore undertaken to evaluate the requisite phytochemical screening andthe constipation activity of Spermacoce hispida by using albino Wistar rats. Phytochemical analysis was carried out with different chemical reagents.Constipation activity of Spermacoce hispida was analyzed by using albino Wistar rats.To cure the irritant bowel syndrome using the whole...
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Posted by admin on Dec 1, 2013 in |
Swertia chirata Buch Ham (Gentianaceae) commonly known as chiratais a perennial herb. The present study was undertaken to evaluate the immunomodulatory effect of methanolic extract of S. chirata aerial part on Swiss albino mice. Haemagglutination Test (Humoral antibody response) and Delayed-type hypersensitivity (DTH) response test and were done to investigate the effect of methanolic extract of S. chirata on humoral and cell mediated immunity responses and flow cytometric studies for the estimation of T lymphocytes (CD3 and CD19) and Th1 cytokines (IL-2, IFN-γ and IL-4). Levamisole and Cyclophosphamide were used as immunostimulatory and immunosuppressive standard drugs. The methanolic extract of S. chirata showed dose related decrease in primary and secondary antibody response and Delayed type hypersensitivity (DTH) response with the maximum decrease at 200 mg kg-1 b wt (primary antibody response- 5.41±0.24, secondary antibody response- 5.39±0.19 and DTH response- 0.62±0.05). It also showed dose dependent decrease in the production of T lymphocytes (CD3 and CD19) and Th 1 cytokines (IL-2, IFN-γ and IL-4). The maximum decrease in the production...
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Posted by admin on Dec 1, 2013 in |
Human Papilloma Virus (HPV) is the smallest virus in the world. HPV is a non-enveloped double-stranded circular DNA virus, which can widely infect human skin and reproductive tract and respiratory epithelium. HPV also has a close relationship with benign and malignant tumors. There is no universal HPV treatment. Although there is a vaccine called Gardasil that can prevent some diseases caused by HPV, it is not recommended for everyone and does not eliminate the chance of getting other types of HPV. Thus, the aim of the present study is to design a subunit vaccine against HPV using bioinformatics approaches. In order to achieve our objective, we have used B-cell and T-cell epitope prediction methods. The possible vaccine target was proposed by using the conserved sequence among the chosen L1 binding protein from twenty different sequences. Structure prediction of this sequence by PSIPRED revealed that one helix is present in the sequence. The use of immune-informatics has greatly revolutionized the field of vaccine research, discovery and development. It demands the...
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Posted by admin on Dec 1, 2013 in |
Currently there has been an increased interest globally to identify the plant origin with free radical scavenging properties and have great importance as therapeutic agents in several diseases due to oxidative stress. Lipid peroxidation of cellular membranes has also been implicated in various disease processes, including cardiac ischemia-reperfusion injury. In recent years, the use of natural antioxidants present in food and other biological materials has attracted considerable interest due to their presumed safety, nutritional and therapeutic value. Shorea robusta has wide range of pharmacological activity but the cytoprotective activity against oxidative damage has not yet been documented. The present study was investigated the cytoprotective activity of Shorea robusta extract (SRE). The results of the study indicate that the cytoprotective role of SRE may be related to counteraction of free radicals. The mechanism of cytoprotective is to be worked out in future...
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