Posted by admin on Oct 1, 2013 in |
Standardization of herbal formulation is essential in order to assess the quality of drugs for therapeutic value. The present work is an attempt to standardize ‘Bhunimbadi Churna’, an Ayurvedic polyherbal formulation, used in fever and diabetics etc. The various parameters performed included organoleptic characteristics, physico-chemical parameter, physical characteristics of Churna, preliminary phytochemical, Heavy metal and Microbial analysis and high performance thin layer chromatography (HPTLC) analysis. The results obtained may be considered as tools for assistance to the regulatory authorities, scientific organizations and manufacturers for developing standard formulation of great...
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Posted by admin on Oct 1, 2013 in |
Aim: The purpose of this study was to assess the impact of Peptostreptococcus on type 2 diabetes mellitus patients with secondary root canal infections by evaluating the prevalence of this bacterial species using culture and PCR technique and to correlate their association with specific endodontic signs and symptoms in Indian population. Materials and method: 88 subjects scheduled for root canal retreatment were divided into two groups comprising of 44 subjects with history of type 2 diabetes mellitus (group1) and 44 non-diabetic subjects as control (group 2). Root canal samples were collected as per Moller’s criteria using sterile paper points. The prevalence of Peptostreptococcus in secondary root canal infections was analysed using advanced culture technique and species-specific PCR technique. Statistical analysis was done using Student unpaired T test and Pearson’s Chi-Square test. RESULTS: In group1, Peptostreptococcus was detected in 52.2% and 54.5%, in contrast group2 was associated with 27.3% and 31.8% of Peptostreptococcus using culture and PCR respectively, with statistically significant association of Peptostreptococcus with type 2 diabetes mellitus (p=0.014)....
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Posted by admin on Oct 1, 2013 in |
Rice is much revered oriental food and the most important tropical cereal crop. It is the staple food of about half the human race and is often the main source of calories and the principal food of many millions of people. Health benefits of rice include providing fast and instant energy, stabilizing blood sugar levels and providing essential source of vitamin B1 to human body. In this study, a bioinformatics and molecular modeling approach was adopted to explore properties and structure of rice antioxidant proteins. The antioxidant proteins selected for this study are CYS PRX (P0C5C9, Q6ER94, P0C5D1) and PRDX (Q9FR35, Q7F8S5, Q9SDD6). Physico-chemical characterization interprets properties such as pI, EC, AI, GRAVY and instability index and provides data about these proteins and their properties. Prediction of motifs, patterns, disulphide bridges and secondary structure were performed for functional characterization. Three-dimensional structures for these proteins were not available as yet at PDB. Therefore, homology models for these antioxidant proteins were developed. The modeling of the three dimensional structure of these proteins shows that models generated by...
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Posted by admin on Oct 1, 2013 in |
The present study deals with the formulation and evaluation of gastroretentive floating tablets of dextromethorphan. Dextromethorphan is a highly potent and commonly used antitussive agent. It has no narcotic, analgesic or addictive properties and its potency as an antitussive agent is almost equal to that of codeine. The purpose of this research is to increase the gastric residence time by preparing gastroretentive floating tablets whereby making it available at its site of absorption and to achieve an extended action for a time period of 12 hrs. Dextromethorphan floating tablets were prepared by direct compression method using various grades of METHOCEL, POLYOX and CARBOPOL with three different concentrations. Preformulation studies were carried out and the compatibility of the drug with the excipients was confirmed through differential scanning calorimetry studies. The prepared gastroretentive floating tablets were evaluated for uniformity of weight, hardness, friability, density, drug content, floating lag time, floating time, swelling index and in vitro dissolution studies. The optimized formulations F3, F5 and F11 showed a floating time more than...
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Posted by admin on Oct 1, 2013 in |
In the present work in mathematical modeling, quantitative structure activity relationship (QSAR) studies were performed on some 5,6-dihydro-2-pyrones derivativesusing statistical work.Using only 4 topological and physico-chemical molecular descriptors, we have achieved 84.81% correct classification of the compounds with and without its activity.A heurisimatedtic algorithm selects the best multiple linear regression(MLR) equation showed the correlation between the observed values and the estimated values of activity is very good(R=0.9209, R2 =O.8481, PRESS=0.7312, 14Rcv2″> =0.8210, SPRESS =0.2074). The results are discussed in the light of the main factors that influence the inhibitory activity of the HIV-1 protease....
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