Posted by admin on Nov 1, 2013 in |
Enset (Ensete ventricosum, Musaceae), a plant widely cultivated in south and southwest of Ethiopia, has been shown to be a rich source of starch. In an effort to produce directly compressible matrix-forming excipient, native enset starch was acetylated. Starch acetates (SA) with degrees of substitution (DS) of 0.672 and 2.142 were evaluated. Fourier transform infrared (FTIR) spectra of the modified starches verified the acetylation of the starch molecules. Further investigations revealed that acetylation increased swelling power and solubility, improved flow property and compactability of the starch. The tensile strength of SA matrix tablets increased with an increase in DS. Plain tablets of SA with DS 0.672 disintegrated within 3 min while those of SA with DS 2.142 did not disintegrate over a period of 2 h. Dissolution studies of theophylline loaded SA tablets conducted in 0.1 N HCl for the first 1.5 h and in phosphate buffer pH 6.8 for the remaining study time revealed the change in drug release rate from rapid to sustained release (>12 h) as...
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Posted by admin on Nov 1, 2013 in |
Cassia fistula L. (Fabaceae) fruits are reported to possess a wide range of therapeutic properties. In the present work, an HPTLC method has been developed and validated for estimation of β-sitosterol content in C. fistula fruit collected from different geographical regions in and outside India and its polyherbal formulation. Chromatographic separation was achieved on HPTLC plates pre-coated with silica gel 60 F254 using toluene: ethyl acetate: methanol (7:1:0.5, v/v/v) as a mobile phase. A compact spot of β-sitosterol at Rf value of 0.46 ± 0.02 was observed in all the samples of C. fistula by derivatizing the HPTLC plate with 10 % methanolic sulphuric acid reagent followed by its densitometric scanning using CAMAG TLC scanner 4 at 366 nm. The method was validated as per ICH guidelines. Finding of the present work can be used as a routine quality control tool for the assessment of C. fistula fruits in terms of its β-sitosterol...
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Posted by admin on Nov 1, 2013 in |
Benign Prostatic Hyperplasia (BPH) is a common progressive disease among men, with an incidence that is high among elderly. Velvanga parpam (VP) has been employed as traditional remedy for Benign Prostatic Hyperplasia (BPH) which is a herbo mineral formulation. As a mandate, steps were taken to evaluate safety profile of VP in rats and mice following OECD guidelines. Acute toxicity studies, different doses of VP were administered orally to rats once daily for one week. Sub-acute toxicity studies were carried in four different groups in which VP was administrated orally to rats once daily for 28 days in various doses ranging from 2.5, 5, 10 Mg/kg for mice respectively. Detailed hematological, biochemical, necropsy and histopathological evaluation of organs was performed for all animals. The VP was well tolerated and no toxic manifestations were seen in any animal. Histopathological analysis revealed that Spleen, Testes, Pancreas, Lung, Liver, Brain, Heart, Stomach, Intestine, Bone, Ovary, and Kidney tissues of treated groups did not show any signs of toxicity. Mortality observed in highdose....
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Posted by admin on Nov 1, 2013 in |
The aim of this research wok is to formulate and evaluate Ciprofloxacin solid dispersions system by using the different techniques. This will increase the solubility of the drug or Ciprofloxacin and give the immediate release of the drug from the formulations. The main objective is to formulate a drug product as immediate release oral solid dosage form of Ciprofloxacin solid dispersion system which is considered to be stable, robust quality and enhanced dissolution rate. To optimize the method of manufacture by formulate the Ciprofloxacin solid dispersion system by various techniques like Physical mixing, Co-grinding, Kneading and solvent evaporation techniques. The disintegrating agent used in the present study is Crosscarmellose sodium. Among the four different techniques used for preparation of solid dispersions solvent evaporation technique has shown the increase in dissolution rate that is the Trail-5 was found to have a faster solubility and dissolution property which was prepared by using Crosscarmellose sodium as a disintegrant in the ratio of...
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Posted by admin on Nov 1, 2013 in |
Microwave assisted organic synthesis (MAOS) has emerged as frontier in pharmaceutical research for synthesis of newer drugs and implementing GREEN chemistry. Arylacetamides are pharmaceutically interesting as they show various biological activities such as analgesic, local anesthetic, antiarthritic, antiarrhythmic activities, etc. In arylacetamides the nature of aromatic ring and its substituent is primary determinant for its activity. To serve this purpose, we have decided to substitute arylacetamide with benzotriazole which may exploit the analgesic potential of newly synthesized derivatives i.e N-(Alkyl or Aryl)-2-(1H-benzotriazol-1-yl)-acetamides and thus it may be helpful in reducing the pain without having side effect of...
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