Posted by admin on Nov 1, 2013 in |
The study was undertaken to compare the efficacy and safety of Glimepiride and Metformin in the management of patients with type 2 DM. The present invention is directed to a pharmaceutical composition in the form of a capsule with increased bioavailability as well as the process for obtaining said composition. The tablet of the present invention comprises two active ingredients comprising two oral hypoglycemic agents: one phase with a sulphonylurea, such as immediate release Glimepiride and second phase with a biguanide, such as extended release Metformin hydrochloride (Metformin HCL). This composition of capsule, which can include over 500mg of Metformin HCL (i.e. up to daily requirements of each patient), is to be orally administered once or twice a day. The combination of these hypoglycemic agents has a synergic effect.Finally we can explain that the availability of Metformin-Glimepiride combination can minimize the effects of diabetic conditions. From the complete work we assume that these hypoglycemic agents have a synergistic effect and therefore a greater effectiveness in controlling the blood glucose...
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Posted by admin on Nov 1, 2013 in |
Coccinia indica is a climbing, herbaceous, branched tropical vine native to tropical Asia, including India. Being a part of Indian traditional medicine for ages, it has been widely used in reducing blood sugar among various other uses. The primary objective of this study was to investigate the reported anti-diabetic potential of methanolic polyherbal extract of Coccinia indica leaves in streptozotocin induced diabetic rats. Hyperglycemia was induced in overnight fasted healthy adult Wister albino rats by a single intraperitoneal injection of Streptozotocin made in citrate buffer. The diabetic rats in groups received treatment with two different concentrations of the extract, the standard drug and saline. The effectiveness of extract in the maintenance of blood glucose level in both normal and diabetic rats is indicated by significant reduction of the elevated blood sugar level after 10 days of treatment (up to 41.87%) which is comparable to that of standard drug glibenclamide (43.50%) under similar conditions. The results from the experimental studies reflect the efficiency of extract to control blood glucose levels,...
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Posted by admin on Nov 1, 2013 in |
Aim of the study:In-vitro study of Anticonvulsant activity on the fruits extracts of Coccinia indica (Wight &Arn.) induced maximal electroshock seizure (MES) model in rats. Materials & methods: For the assessment of anticonvulsant activity, the animals were divided into five groups of five animals each albino rats. Group I received Normal saline, Group II received Phenytoin, Group III received 200 mg/kg of CIEE suspended in Tween 80, Group IV received 400 mg/kg of CIEE suspended in Tween 80, and Group V received 600 mg/kg of CIEE suspended in Tween 80. The results are expressed in mean ± S.E.M. (n=5) Statistical analysis was done by one way ANOVA, followed Dunnett multiple comparison test vs. control. P<0.01 was considered as statistically significant. Results: In the present In vitro study, an anticonvulsant effect of ethanolic extracts of fruits Coccinia indica Wight & Arn. has been determined duration of HLTE 14.96, 3.49, 9.68, 8.20, 4.90 sec. The CIEE exhibited maximum anticonvulsant activity at 4.90 sec. at 600mg/kg (P<0.01) and it was significant when...
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Posted by admin on Nov 1, 2013 in |
Trigonella foenum-graecum is an annual plant in the family Fabaceae. The distinctive cuboid-shaped, yellow to amber coloured fenugreek seeds are frequently encountered in the cuisines of the Indian subcontinent. In this study, Trigonella foenum-graecum is used as an experimental matrix. Ultrasound-assisted extraction (UAE) of total flavonoids from Trigonella foenum-graecum is studied with dual wavelength UV-VIS spectrophotometer. Effects of various factors including ratio of material to liquid, ultrasonic time, methanol concentration and extraction times on extraction yield of total flavonoids are evaluated. Then, optimization of total flavonoid compound (TFC) extraction from Trigonella foenum-graecum seed is investigated using response surface methodology (RSM) in this paper. Statistical analysis of the experiments indicated that Ratio of material to liquid and methanol concentration significantly affected TFC extraction (p < 0.01). The Box-Behnken experiment design shows that polynomial regression models are in good agreement with the experimental results, with the coefficients of multiple determination of 0.9758 for TFC yield. The optimal conditions for maximum TFC yield are 70% methanol, 50min and 30 (v/w) liquid to solid ratios with a 2...
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Posted by admin on Nov 1, 2013 in |
The compound 2, 6-diamino-3-phenylazopyridine hydrochloride salt is a genito-urinary antiseptic drug under the trade name Pyridinium. This study is directed towards the occurrence of an oxidation reaction to convert the tertiary amine present in 2, 6-diamino-3-phenylazopyridine hydrochloride to form an N-oxide derivative as an impurity in the process for its preparation. This was done by the independent synthesis of 2, 6-diamino-3-phenylazopyridine-1-oxide hydrochloride salt by two independent routes. The presence of three amine functions in the molecule required first to protect the primary amine groups by derivatisation so that oxidation occurs exclusively at the tertiary amino group of the pyridine ring. 2, 6-diamino-3-phenylazopyridine was acetylated to get 2, 6-diacetamido-3-phenylazopyridine whose structure was confirmed from 1H NMR and mass spectral data. The oxidation of diacetyl derivative with peracetic acid resulted not only in the N-oxide formation but also in the cleavage of one of the acetamido group to give 2(6)-acetamido-6(2)amino-3-phenylazopyridine-1-oxide. The alkaline hydrolysis of the N-oxide form gave 2, 6-diamino-3-phenylazopyridine-1-oxide which on treatment with hydrochloric acid gave 2, 6-diamino-3-phenylazopyridine-1-oxide hydrochloride. In...
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