Posted by admin on Jan 1, 2014 in |
The aim of current research work was to develop sustain release formulation of Theophylline. Modified plant derived Fenugreek gum (FG) polymer was synthesized and used as matrix forming agent. Matrix tablet formulations were prepare by wet granulation technique using modified fenugreek gum in different concentration. The prepared formulations were evaluated for physical properties such as tablet hardness, weight variation, drug content and In vitro drug release. Formulation prepared with drug: polymer weight ratio of 1:2 showed desired release profile as per USP specification. FTIR study showed absence of chemical interaction between drug and polymer. The optimized formulation was found to show stability for two month as per ICH guideline. Study suggested that modified fenugreek gum can be used as extended release...
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Posted by admin on Jan 1, 2014 in |
Croton membranaceus (Mull. Arg.) Euphorbiaceae is a shrub that grows wild in West Africa. It is used by Ghanaian Traditional Medical Practitioners in the treatment of benign prostatic hyperplasia (BPH). Research findings have provided some scientific bases for the use of this plant in the treatment of BPH. Therefore, the aim of the present study was to investigate the antihyperglycaemic and antioxidant activities of C. membranaceus. There isalso evidence suggesting an association between BPH and diabetes through a common pathogenic mechanism. Research findings also suggest that oxidative stress may be one of the major factors responsible for the development of BPH and diabetes. The antihyperglycaemic activity of three different doses (100, 300, 600 mg/kg body weight) of the ethanol (70 %) extract of C. membranaceus root was studied in streptozotocin-induced diabetic rats. The antioxidant activity of the ethanol extract of C. membranaceus root was also investigated using the spectrophotometric 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging method. C. membranaceus root extract showed a dose-dependent reduction of glucose levels over both short term and...
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Posted by admin on Jan 1, 2014 in |
One of the problematic aspects of palliative-hospice care is pharmaceutical providing of the patients at specialized institutions, hospices. The relevance of the work is due to the lack of research about the medicineconsumption by patients at the hospice in Ukraine. Therefore the aim of the research was to study the range, cost, prescription frequency and the cost of patient pharmacotherapy at the hospice.The methods of content and frequency analysis and also,the integrated ABC/FMR/VED-analysis were used for the study.At the first research stagewere analyzed the clinical and basic statistical characteristics of hospice patients. At the second stage, the integrated ABC/FMR/VED analysis of prescribed drugs has been conducted. Then the definition of frequently prescribed medications and main therapeutic groups, using frequency analysis,hasbeen performed. The final step is the calculation of patients pharmacotherapy cost and the individual therapeutic medicationgroups.The analysis of clinical and statistical characteristics of hospice patients has showed that 75.6% of patients at the hospice were women and 48.9% of all diseases present were cardiovascular diseases. 139 medicinal products have...
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Posted by admin on Jan 1, 2014 in |
A spectrophotometric method for determination of cephalexin is proposed. This method is based on the formation of a colored compound in the reaction of cephalexin with sodium 1,2-naphthoquinone-4-sulfonate (NQS). The effects of various experimental parameters in this reaction were investigated and optimized using central composite design (CCD). Twelve experiments with two factors and five levels for each factor were designed. These factors include concentration of NQS and pH. A full-quadratic polynomial equation between the absorbance as the response and the studied parameters was established. After removing the non-significant terms from the model, response surface method was used to obtain the optimum conditions. The optimum values of factors were 20.0×10-4 M for concentration of NQS and 9.6 for pH. The maximum absorption wavelength and the value of absorptivity of the colored product were 475 nm and 1.79×103 L mol−1 cm−1, respectively. The absorbance of the reaction product obeys Beer’s law in the range 1.5-34.0 mgL-1. The detection limit of the method was 0.43 mgL-1. This method is rapid and simple,...
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Posted by admin on Dec 1, 2013 in |
The onion (Allium cepa L), also known as the bulb onion or common onion, is used as a vegetable and is the most widely cultivated species of the genus Allium. Allium cepa L belongs to the family Lilliaceae. The onion has a wide range of beneficial actions on the body and when eaten (especially raw) on a regular basis will promote the general health of the body. The parameters selected were preliminary phytochemical screening and sedative hypnotic activity by chimney test. The Allium cepa Linn powder was successively extracted with benzene, chloroform, ethylacetate, ethanol and water for the identification of the best solvent. Preliminary phytochemical screening was carried out for all the extracts and maximum chemical constituents were observed in the ethanolic extract. The sedative and hypnotic activity were tested by using ethanolic extract on mice by using chimney test and found to be effective at a dose of mg/kg when compared to the reference standard. In conclusion it can be said that Allium cepa L possess Sedative and...
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