Posted by admin on Dec 1, 2013 in |
In the present paper, synthesis of new series of 1,3,4- oxadiazole derivatives incorporating substituted dihydropyrimidinone and chloroquinoline moieties 4(a-j) has been reported. All the synthesized compounds were characterized by FTIR, 1H NMR and Mass spectroscopy. The compounds were screened for their in vivo anti-inflammatory activity by the carrageenan induced rat paw edema method and in vitro anti-bacterial activity against some gram positive and gram negative strains of bacteria. This pharmacological activity evaluation revealed that among all the compounds screened, compounds 4c, 4e and 4g were found to have promising anti-inflammatory activity. Moreover, compounds 4b, 4c, 4d, 4g and 4j exhibited promising anti-bacterial activity against the selected pathogenic strains of...
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Posted by admin on Dec 1, 2013 in |
The aqueous and alcoholic leaf extracts of Annona squamosa, Azadirachta indica and Calotropis procera were tested against the cattle ticks. The fresh and leaf powder extracts were tested individually and also in combinations under in vitro conditions. The extracts of A. indica showed maximum mortality rate of ticks followed by A. squamosa and C. procera when tested individually. In combination, the hot water extracts of leaf powder showed 100% mortality whereas ethanol and methanol extracts showed 83% and 80% of mortality respectively. Based on the above experimental results, it is confirmed that the selected plant materials possess more acaricidal activity against cattle ticks. Extracts in combination are more effective than single drug used. Since the herbal drugs are cost effective and easy to process, it can be used as an alternative medicine to control cattle...
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Posted by admin on Dec 1, 2013 in |
Zanthoxylum rhetsa DC. shoot is highly priced and one of the most preferred folk vegetable among the Indigenous people of Arunachal Pradesh, India. It is also used as folk medicinal purpose among the Adi tribe of the state. The methanol extract of shoot were evaluated for total phenolic content (Folin-Ciocalteu’s method), total flavonoid content (colorimetric method) and antioxidant potential ((DPPH & ABTS). Folk use, various mode of cooking, demand as vegetable in the local market is also discussed in this paper. The methanol extract contains considerable phenolic (117.95±3.22 mg GAE/g) and flavonoid (120.14±2.31 µMRE/g) with no much significant correlation between the total content of phenolic and flavonoid and antioxidant potential was found as IC50 value of 271±3.5µg/ml were recorded in ABTS assay and IC50 value of 306± 4.21µg/ml was found in DPPH...
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Posted by admin on Dec 1, 2013 in |
Phytochemical, HPTLC and Heavy metal analysis of Leaf of Leonotis nepetaefolia was done. Qualitative phytochemical screening of Leaf was done using different solvents which showed the presence of various vital secondary metabolites. Neutraceutical studies revealed the presence of carbohydrates, proteins and aminoacids. HPTLC studies confirmed the presence of flavonoids, diterpene, phenolic class of compounds. Heavy metal analysis showed the presence of Lead, Cadmium, Chromium and copper in all the samples...
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Posted by admin on Dec 1, 2013 in |
The present study is carried out with the methanolic extract of leaves of Millettia pachycarpa benth. Traditional use of it inspired us to investigate the blood corpuscular protective power of this plant as it used as blood tonic in Chinese traditional medicine. By the phytochemical screening we have both flavonoids and steroids. There’s also alkaloids are found which have extensive physiologic action embodying analgesic activity. This investigation is made following the most simple, reliable and less time consuming method. As the human red blood corpuscular membrane is similar to lysosomal membranes that influence inflammatory process. Result obtained using methanolic extract of M. pachycarpa have better acceptance as it shows good response in inhibiting hemolysis (34.30%) at highest concentration and these investigation surely stimulate further screening and isolation...
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