Posted by admin on Dec 1, 2013 in |
In this study, an attempt has been made to approach of developing antibacterial finish using aromatic herbal oils. The five different herbal oils like Palmarosa, Petitgrain, Tea tree, Thyme, Lavender oil were screened with disc diffusion method against bacteria that normally exist like Staphylococcus aureus, Escherichia coli. The result showed good efficiency in Thyme oil when compared to other oils. Bamboo and Tencel fabrics are treated with thyme oil. The thyme oil finished fabric was assessed with anti- bacterial test (AATCC 147), anti-odor test (Organoleptic test) .The results indicates thyme oil treated fabric showed excellent antibacterial activity in both Bamboo and Tencel fabric compared to untreated sample. For anti-odor test Bamboo fabric shows good...
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Posted by admin on Dec 1, 2013 in |
The study was designed to determine the acute and sub-chronic toxic effects of aqueous extract of Gmelina arborea (Roxb.) in healthy male Wistar rats. An aqueous bark extract of G. arborea was administered at graded doses (0.25-2.00 g/kg) to Wistar rats in the acute toxicity test. Sub-chronic toxicity was evaluated by daily administration of the extract at 1.00 g/kg to Wistar rats for 30 days. All animals were physically active and no death was observed up to the dose of 2.00 g/kg in the acute toxicity study. The hematological parameters, serum concentration of liver enzymes and relative organ weight did not differ significantly in treated rats as compared to untreated healthy rats (P > 0.05). The histopathological study revealed no treatment-related gross cellular changes in vital organs in treated rats. The administration of the bark extract of G. arborea (1.00 g/kg) was found to be toxicologically safe in Wistar...
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Posted by admin on Dec 1, 2013 in |
Curcumin, a hydrophobic polyphenolic compound derived from the rhizome of the herb Curcuma longa, possesses a wide range of biological applications including anti-cancer. Nanocurcumin particles were prepared by top-down method as its can improve hydrophilic and increase bioavailability. As a result, curcumin concentration was yielded up to 10% (w/w), and the particle size was defined less than 1,000 nm in diameter. The particles were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), dynamic laser light scattering (DLS), and X-ray diffraction (XRD). The acute oral toxicity was done with a dose up to 500 mg per kg of body weight and no dead mice were found indicating the nanocurcumin particles are safe for long-term use. The model of hepatic fibrosis mice was induced by intraperitoneal (i.p) injection of 0.8 mL of carbon tetrachloride (CCl4) in olive oil (1:3 v/v) per kg of body weight. Nanocurcumin particles (15 mg/kg of body weight) were orally administered to hepatic fibrosismouse model in 4 weeks to evaluate the therapeutic potential in comparison...
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Posted by admin on Dec 1, 2013 in |
The Piper betel is an evergreen and perennial creeper belonging to the Piperaceae family, with glossy heart-shaped leaves and white catkin. It is valued both as a mild stimulant and for its medicinal properties. The total phenolic content of methanolic leaves extract was estimated by Folin-Ciocalteu assay method, and was found to be 0.110 mg/CE/g (Catechine Equivalent per gram). However, antioxidant activity of methanolic leaves extract of Piper betel was determined by DPPH free radical scavenging method. The DPPH radical scavenging activity of methanolic extract of Piper betel was found to be highest at 100μl concentration which was 25.2%. Nevertheless, % DPPH scavenging activity of standard ascorbic acid at same concentration was found to be 40%. The % DPPH scavenging activity increases with the increasing concentration. The concentration of Piper betel needed for 50% inhibition (IC50) was found to be 282.31μg/ml whereas 369.19 μg/ml needed for ascorbic...
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Posted by admin on Dec 1, 2013 in |
A high-performance liquid chromatography (HPLC) method has been developed for the determination of isosorbide mononitrate and its related substances in isosorbide mononitrate and sodium chloride injection. An C18 column (5μm, 250 ×4.6 mm) was used for the determination, with methanol and water (25:75,v/v)as the mobile phase at the flow rate of 1 mL min−1. The detection wavelength was 210 nm. The related substances were quantitated versus an external standard. The method was capable of resolving all of the two known related substances. The two related substances were isosorbide dinitrate (ISDN) and 2- isosorbide mononitrate (2-ISMN), respectively. The method was successfully applied to quantify related substances. The limits of detection of isosorbide mononitrate, isosorbide dinitrate and 2-isosorbide mononitrate (2-ISMN) were all 0.3ng. And the limits of quantitation of isosorbide mononitrate, isosorbide dinitrate and 2- isosorbide mononitrate (2-ISMN) were all 0.8ng. The method was found to be accurate, precise, specific, linear and sensitive, for the...
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