Posted by admin on Jul 1, 2013 in |
A simple and rapid high performance thin layer chromatographic (HPTLC) method was developed for the assay of colchicine in bulk drug, pharmaceutical preparations and biological fluids. The method has a linear range of 4 – 35 μg/ml. The limits of detection and quantification were 1 and 4 μg/ml respectively. The results obtained by the proposed method were compared statistically by means of Student t-test and by the F-test with those of the reported method. The two were shown in good agreement. No interference was observed from common pharmaceutical excipients....
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Posted by admin on Jul 1, 2013 in |
An increased inclination has been observed for the use of herbal drugs in chronic and incurable diseases. Treatment of psychiatric diseases like Schizophrenia is largely palliative and more importantly a prominent adverse effect prevails with the majority of antipsychotic drugs, which are the extrapyramidal motor disorders. This study was a trial to evaluate the neuroleptic activity of the ethanolic extracts of Nardostachys Jatamansi with different antipsychotic animal models. Two doses of the extract (100 and 200mg/kg) were used for this study with 5 different animal models. After that, the concentration of the dopamine neurotransmitter was estimated in two different regions of the brain viz. Frontal cortex and Striatum. The result of the study indicated a significant reduction of amphetamine induced stereotype and conditioned avoidance response for the extracts compared with the control group, but did not have any significant effect in phencyclidine induced locomotor activity and social interaction activity. However the extract showed minor signs of catalepsy compared to the control group. The study also revealed that the neuroleptic...
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Posted by admin on Jul 1, 2013 in |
Synthetic analgesic drugs have major side effects like gastritis, gastric ulcer, kidney disorders and cardiac arrhythmias. So, use of natural or herbal analgesics is an important and growing part of the pain-control and new discoveries are made practically every year. Many of these drugs commit the side effects like Morphine is responsible do work against heavy sedation and may elevate mood in distressed patients as do the antidepressants. Caffeine, release the histamine in more amounts, also have stimulation. And the use of cannabis like a medicine remains a debated issue. Analgesic herbs are the therapeutic herbs with analgesic effect that are commonly known as pain relief herbs or simply the pain herbs. Analgesic herbs are natural pain reliever that reduce or eliminate pain. These pain relief herbs are available in the market in analgesic topical forms like essential oil and analgesic cream- that can be directly applied at the pain sites- as well as in form of capsules, tea and tinctures for pain relief. So, Author proposed the comparative...
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Posted by admin on Jul 1, 2013 in |
The selected amide and ester derivatives of ferulic acid were subjected to preservative efficacy testing in an official antacid preparation, (Aluminium Hydroxide Gel-USP) against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Aspergillus niger as representative challenging microorganisms as per USP 2004 guidelines. The selected derivatives were found to be effective against all selected strains and showed preservative efficacy comparable to that of standard and even better in case B. subtilis and C. albicans. The 8- hydroxy quinoline ester derivative showed better preservative efficacy than standard as well as other derivatives and have better potential for use in the pharmaceutical...
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Posted by admin on Jul 1, 2013 in |
A series of some New 2, 3-dihydro-1, 5-benzodiazepines has been synthesized using condensation reaction of o-phenylenediamine and various substituted chalcones in presence of DMF as solvent and screening of antibacterial and antifungal activities of synthesized...
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