Posted by admin on Dec 1, 2013 in |
Human Papilloma Virus (HPV) is the smallest virus in the world. HPV is a non-enveloped double-stranded circular DNA virus, which can widely infect human skin and reproductive tract and respiratory epithelium. HPV also has a close relationship with benign and malignant tumors. There is no universal HPV treatment. Although there is a vaccine called Gardasil that can prevent some diseases caused by HPV, it is not recommended for everyone and does not eliminate the chance of getting other types of HPV. Thus, the aim of the present study is to design a subunit vaccine against HPV using bioinformatics approaches. In order to achieve our objective, we have used B-cell and T-cell epitope prediction methods. The possible vaccine target was proposed by using the conserved sequence among the chosen L1 binding protein from twenty different sequences. Structure prediction of this sequence by PSIPRED revealed that one helix is present in the sequence. The use of immune-informatics has greatly revolutionized the field of vaccine research, discovery and development. It demands the...
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Posted by admin on Dec 1, 2013 in |
Currently there has been an increased interest globally to identify the plant origin with free radical scavenging properties and have great importance as therapeutic agents in several diseases due to oxidative stress. Lipid peroxidation of cellular membranes has also been implicated in various disease processes, including cardiac ischemia-reperfusion injury. In recent years, the use of natural antioxidants present in food and other biological materials has attracted considerable interest due to their presumed safety, nutritional and therapeutic value. Shorea robusta has wide range of pharmacological activity but the cytoprotective activity against oxidative damage has not yet been documented. The present study was investigated the cytoprotective activity of Shorea robusta extract (SRE). The results of the study indicate that the cytoprotective role of SRE may be related to counteraction of free radicals. The mechanism of cytoprotective is to be worked out in future...
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Posted by admin on Dec 1, 2013 in |
The aim of the study is to evaluate the diagnostic DNA profiles of the assessment of semen analysis data with respect to male fertility potential. Seman analysis taken form 50 patients of known fertility and 50 suspended infertility were studied by conventional semen analysis by suitable methods. The acridine orange test was used to assess the integrity of sperm DNA. The data throw doubt upon the validity of an approach based on the number of deviations for the normal standard values defined by the WHO. The alternative approach as specific semen characteristics (particularly morphology) as the major predictor of fertility produced no beneficial results. The means of sperm concentration in fertile males was significantly higher than infertile males (62.7±18.7 million vs. 36.7±25.40 million). Total sperm motility of fertile males also was significantly higher compared to infertile (56.32±0.07% vs. 28.8±10.7%). Normal sperm morphology of fertile males was also significantly higher compared to infertile (24.5±8% vs. 12.87±4.6%). According to these results we can conclude that testing sperm DNA damage is helpful...
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Posted by admin on Dec 1, 2013 in |
Antibacterial agents are essential drugs for human health and welfare. Many pharmaceutical industries have produced a number of antibiotics and resistance to these drugs by microorganisms increased. This development of resistance has necessitated the search for new anti-bacterial agents. Medicinal plants like spices are considered as a good source of natural products for maintaining human health since decades. The use of these plant extracts with known antimicrobial properties can be of great significance in therapeutic treatments. The main objective is to study the antimicrobial activity of combined plant extracts and to screen their anti-bacterial efficacy with the individual plant extracts by using Disc diffusion method against 5 bacterial strains (Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Proteus vulgaris). Aqueous extracts like Infusions and Decoctions from the following plants were prepared: Syzygium aromaticum (Clove), Laurus nobilis (Bay leaf), Cuminum cyminum (Cumin) and the comparison is made between individual extracts with the combined mixture of infusions and decoctions. The combination of three infusions was found to be more effective...
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Posted by admin on Dec 1, 2013 in |
This study evaluated methanolic extract of Filicium decipiens (MFD) on reducing hyperglycemia and hyperlipidemia in streptozotocin-induced diabetic rats. MFD was orally administered once a day after 3 days of streptozotocin -induction at 100,200 and 400 mg/kg for 45 day and the results showed that serum fasting blood glucose, Glucose – 6 – phosphotase , Fructose 1, 6 –phosphotase in hepatic tissues ,TC, free fatty acids , phospholipids, and TG in serum levels were significantly decreased, whereas Hb and HbCA1in blood and serum HDL, Glucokinase, Glucose – 6 – Phosphate Dehydrogenase in hepatic tissues and liver and muscle glycogen level were increased. The dosage of 400 mg/kg is more effective than that of 100, 200 mg/kg. These results suggest that the MFD possesses antidiabetic and hypolipidemic effects in streptozotocin -induced diabetic...
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