Posted by admin on Aug 1, 2013 in |
Walnuts from Northwest region of Syria was collected to determine Omega-6 (linoleic acid (LA, 18:2n-6)) and Omega-3 (α-linolenic acid (ALA, 18:3n-3)) in their oils, also called essential fatty acids (EFAs). This work was carried out using two different portions of samples. First samples were collected at harvest and second samples stored for one year under normal conditions. The extraction of the oil contained in Walnuts was done with hexane by ultrasonic technology, extract contained fatty acid and these fatty acids were estered. Fatty acid methyl esters were analyzed by gas chromatography with flame ionization detection (GC-FID). Syrian Walnuts major fatty acids were 18:2n-2 (linoleic acid) and 18:3n-3 (α -linolenic acid). Regarding n-6/n-3 ratio corresponded to the desired profile; Syrian Walnuts could be of potential interest due to their high nutritive value and lipid...
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Posted by admin on Aug 1, 2013 in |
The main objective of present work was to formulate and evaluate swellable controlled porosity osmotic tablets of Acyclovir for the treatment of herpes simplex. This formulation aims to release the drug in zero order pattern, increase bioavailability, reduce frequency of drug dosing and hence increased patient compliance. Acyclovir is a synthetic purine nucleoside analogue that is specially activated by Herpes Simplex Virus (HSV) induced thymidine kinase, and inhibits viral DNA polymerases as well as acting as a chain terminator. The technique used for the preparation of tablets was direct compression followed by deep coating of core tablets and total nine formulations (F1-F9) were prepared. Prior to compression, the prepared granules were evaluated for flow and compression characteristics. Prepared osmotic drug delivery system was also evaluated for in vitro drug release study. In vitro release profile of all formulations was in range from 54.12-99.85%. The formulation F2 was best amongst all and showed 56.58% drug release in 12 hr and 98.92% in 24 hrs. Zero order drug release kinetics was...
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Posted by admin on Aug 1, 2013 in |
Topoisomerase enzymes are highly expressed in cells which undergo rapid multiplication. Inhibition of this enzyme represents a potential therapeutic approach for diseases such as cancer. In order to understand the structure activity correlation of 2, 4, 6 pyridine based topoisomerase inhibitor, we have carried out a combined pharmacophore modelling, 3D-QSAR studies, molecular docking and virtual screening studies. A five point pharmacophore with hydrogen bond acceptor (A), hydrogen bond donor (D) and three aromatic rings (R 5, R 6, R 7) was used to derive a predictive atom based 3d-qsar model. The generated model had showed good correlation coefficient for training set and test set (R2=0.91and Q2=0.827). It was also validated using enrichment factor (EF) and goodness of hit score (GH score) and was used for virtual screening of compounds from ‘zinc drug like database’. Docking study of the hits retrieved from virtual screening revealed the binding affinity of these inhibitors at the active site of topoisomerase enzyme. In silico ADME predictions was also performed. These findings provide a set...
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Posted by admin on Aug 1, 2013 in |
Aim: The present study investigates the effect of Ramipril on blood sugar level and interaction with the oral anti-diabetic drugs in alloxan induced diabetic rats. Method: Rats were divided into 10 groups (n = 6) where Group I –II were normal and Group III –X were diabetic. Ramipril at the dose of 0.9 mg/kg body weight were administered to the normal and diabetic rats. In diabetic groups, the Ramipril was given concomitantly with the each of three Oral anti-diabetic drugs to find-out the effect on blood sugar level .All drugs administered orally once a day for 13 days and at the end of the experimentation Oral Glucose Tolerance Test (OGTT) was conducted. Results: It was observed that in normal rats the Ramipril slightly reduced the blood sugar level which was insignificant (P>0.05) except at ‘30’ min time point. In contrast in, it exhibited the anti-hyperglycemic activity significantly (P≤0.01) at all-time points in alloxan induced diabetic rats. Conclusion: The present study has concluded that The Ramipril has significant anti-hyperglycemic activities...
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Posted by admin on Aug 1, 2013 in |
Aim: Cellulite treatment incorporates iso-slim complex to reload the skin with minerals and trace elements to achieve absolute effectiveness in treating cellulite condition. The revitalizing effect of anticellulite helps to refine and reshape the silhouette and give the body a more toned, defined and firmer appearance. Aim of present work was to develop and investigate a novel delivery system for the fatty skin in the form of liposome delivery system. Method: Phosphatidylcholine, Cholesterol and iso-slim complex were dissolved in chloroform/methanol (2:1, v/v) mixture and subsequently transferred into a pear-shaped flask connected to a Rotavapor (Buchi- type). Rotary evaporation method was used for the formulation of liposomes. Result: Liposome prepared was evaluated for particle size measurement, percent drug entrapment, formulation of dosage forms, Stability Study and in vivo study. Optimized batch had particle size 18.62 um, percent drug entrapment 96.70%. Hence, optimized was batch further evaluated for in vivo study and stability study. Conclusion: The present study has been a satisfactory attempt to formulate and evaluate liposome of iso-slim complex...
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