Posted by admin on Jun 1, 2013 in |
A research was conducted to design a directly compressible filler binder characterized with rapid release and mouth disintegrating. Acacia gum was obtained from local source and was purified using a standard method. Tapioca starch was also extracted from cassava tuber using a standard method. Both primary excipients were evaluated for power properties and coprocessed at varying concentration using mixture of isopropranol and water at ratio 2:1. The various coprocessed placebo composite filler-binders (TSAG) were evaluated for granules and tablets properties. The composite containing 85 % tapioca starch and 15 % acacia gum (TSAG-15) have excellent flow rate, angle of repose, compressibility index and Hausner’s ratio: 25 g/s, 30o, 17.3 %, and 1.2 respective. The placebo tablets of this composite was characterized with high functionality, when compressed at 6.5 KN, gave crushing strength of 102 N, friability of 1.12 %, disintegration time of 5-6 min. Ascorbic acid tablets compacted with the composite filler binder having 80 % TSAG-15 and 20 % ascorbic acid gave good compacts with average crushing strength...
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Posted by admin on Jun 1, 2013 in |
Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40) received Levalbuterol- 0.63mg./2.5ml, TDS via nebulizer for 4 weeks. Baseline and post-treatment estimation of biochemical parameters including, fasting and postprandial plasma glucose levels, serum Na+, serum K+ levels, lipid profile, Monitoring of systolic and diastolic BP and adverse drug effects evaluation were carried out. Results: Significantly changes were in serum lipid profile and blood glucose in both the groups but increase was more in group I. Serum K+ level was decreased significantly (p<0.05) in both groups but decrease was more in group I patients. The fasting and postprandial plasma glucose levels were significantly increased in both the groups but increase was more in group I. Systolic BP increases and diastolic BP decreases after administration of both drugs. There was no significant change observed in Serum Na+ level after...
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Posted by admin on Jun 1, 2013 in |
Carotenoids are accessory coloring pigments found occurring naturally in the plants and some photosynthetic organisms. Recently there has been an increased focus on the health benefits and food applications of these natural pigments. The stability and bioavailability of carotenoids vary significantly across a range of processing paradigms. The present study was planned to investigate stability of carotenoids (β-carotene, lutein and lycopene) subjected to different ranges of temperature and light. It concluded that most stable extract under light is marigold followed by tomato and least stable is carrot. Marigold extract (lutein) is most heat stable followed by tomato extract (lycopene) then carrot extract (β-...
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Posted by admin on Jun 1, 2013 in |
A simple, sensitive, selective, precise and stability indicating high-performance thin-layer chromatographic method for determination of quetiapine fumarate both as a bulk drug and from tablets was developed and validated as per the International Conference on Harmonization (ICH) guidelines. The HPTLC method employed aluminum plates precoated with silica gel G 60F254 as stationary phase. The solvent system consisted of methanol: butanol: ethyl acetate (2:1:1) and give compact spots for quetiapine fumarate with Rf value 0.76 ± 0.01 cm. Densitometry analysis was carried out in the absorbance mode at 220 nm. Linear regression analysis showed good linearity (r2 = 0.999) with respect to peak area in the concentration range of 1000–5000 ng/spot. The method was validated for precision, accuracy, specificity and robustness. The limits of detection and quantitation were 171.65 and 520.18 ng/spot, respectively. The method was validated for precision, accuracy, ruggedness and recovery. Quetiapine fumarate was subjected to acid and alkali hydrolysis, oxidation, thermal and photodegradation. The degraded products were well separated from the pure drug. The statistical analysis proves...
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Posted by admin on Jun 1, 2013 in |
A reversed-phase-liquid chromatographic (RP-HPLC) method was developed for the determination of Paracetamol (PCM) and Dicyclomine Hydrochloride (DICY) in their bulk drug and marketed formulations. A reversed-phase C-18 Phenomenex C18 column (250 mm × 4.6 mm i.d., 5μm) with mobile phase consisting of Acetonitrile: Phosphate Buffer pH (5.5): triethylamine (75:25:0.02 v/v/v) was used with 1.0 ml/ min flow rate and detected at 218 nm. The retention times of Paracetamol and Dicyclomine Hydrochloride were found to be 2.65±0.3 min and 11.32±0.3 min, respectively. Developed methods were validated according to ICH guidelines. Linearity was observed at concentration range of 100-500 µg/ml for Dicyclomine Hydrochloride and 10-50 µg/ml for Paracetamol followed by Beer’s law. The % recoveries of Paracetamol and Dicyclomine Hydrochloride were found to be between 101.05-101.20% and 100.55-100.95%. The percentage RSD for the method precision was found to be less than 2%. The proposed method is precise, accurate, selective and rapid for simultaneous determination of Dicyclomine Hydrochloride and...
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