Posted by admin on Aug 1, 2013 in |
The common cause of leg ulceration in Western countries is venous disease of the lower limb.Venous insufficiency causes appreciable disability. Venous ulcer is one of the most prevalent diseases in the western countries and India, which can hamper personal and professional life of individual. After various methods of modern medicinal treatment and management there is a chance recurrence .This case study is a prospective and intervention to combat long standing & recurring venous ulcer aided by...
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Posted by admin on Aug 1, 2013 in |
Ayurvedic formulations are used to treat a wide variety of diseases including Diabetes Mellitus Standardization of Herbal Formulation is Essential in order to assess the Quality of drugs. The Present Study Reports for Standardization of Eight Herbal Anti-diabetic drugs- Momordica charantia (seeds), Syzigium cumini (seeds), Trigonella foenum (seeds), Azadirachta indica (leaves), Emblica officinalis (fruits),Curcuma longa (rhizomes), Gymnema sylvestre (leaves),Pterocarpus marsupium (heart-wood) individually and in the form of Polyherbal marketed samples of Baidyanath Madhumehari Churna, Shivayu Madhuhari Churna and were compared to the in-house preparation for Physicochemical properties as per WHO Guidelines. The Limits obtained from the different Physicochemical Parameters of the individual Eight Herbal drugs and the Marketed Formulations could be used as Reference Standard for Standardization of the Anti-diabetic drugs in a Quality Control...
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Posted by admin on Aug 1, 2013 in |
Various medicinal properties have been attributed to natural herbs. The use of traditional medicine is widespread in India. These herbal remedies are an important source for the discovery of new antimicrobials against the resistant strains of bacteria. Asavas and Arishtas are specially prepared ayurvedic medicines. They are alcoholic solutions containing all the active ingredients of the drugs of which they are compounded. Asavas are prepared by using herbal juices or herbs soaked in water while Arishtas are prepared by decoction. Different parts of medicinal plants are used traditionally for the preparation of specific asava or arishta that is effective against specific disorder. About 25 different medicinal plants commonly used were selected. Dried powders of these plants were extracted in water. The antibacterial activity of the extracts were then tested by agar well diffusion method against standard cultures of Escherichia coli, Klebsiella aerogenes, Proteus vulgaris, Salmonella typhimurium, Staphylococcus aureus and Bacillus thuringenesis. The individual extracts of Emblica officinalis, Terminalia chebula, Terminalia belerica andWoodfordia fructicosa, Jaggery were active against the test...
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Posted by admin on Aug 1, 2013 in |
The principal derivative of chitin is Chitosan, produced by alkaline deacetylation of chitin, is a non-toxic, biodegradable and biocompatible, cationic polymer. Chitosan has been widely used in the formulation of particulate drug delivery systems to achieve controlled drug delivery. The main objective of the study was to develop enteric coated Chitosan capsule containing budesonide for targeting the ileum and ascending colon sites which were mainly affected in Crohn’s disease. This work describes a new colonic drug delivery system utilizing capsule shells prepared from Chitosan. Coating of drug filled Chitosan capsule with pH dependent enteric polymer like Eudragit S100 / L100 (1:1) provides it a special feature of releasing drug at colonic pH. The in-vivo study involves the Gamma scintigraphic evaluation of enteric coated Chitosan capsule. The enteric coated Chitosan capsule proved to be efficient to deliver the drug at ileum and ascending colon in Crohn’s...
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Posted by admin on Aug 1, 2013 in |
The present study enlightens to enhance the dissolution profile, absorption efficiency and bioavailability of water insoluble drug like Ezetimibe. It is a poorly soluble, highly permeable drug and the rate of its oral absorption is often controlled by the dissolution rate in the gastrointestinal tract. There are several techniques to enhance the dissolution of poorly soluble drugs, in which the “liquisolid compacts” is a promising technique. Different formulations were prepared by using polyethylene glycol-400 as a non-volatile liquid vehicle, with drug and vehicle ratios of 1:5 and 1:7.5, microcrystalline cellulose (Avicel PH 102), starch were used as carrier materials and nm-sized silica gel (Aerosil-200) was used as coating materials. The empirical method introduced by Spireas and Bolton was applied to calculate the amounts of coating and carrier materials required to prepare Ezetimibe liquisolid tablets. Based upon this method, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material ratio from 20:1 to 5:1. They were characterized for different physical...
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