Posted by admin on Feb 1, 2013 in |
The present work aims at evaluating the anti-inflammatory activity of Samadera indica by HRBC membrane stabilization. The prevention of hypotonicity induced HRBC membrane lysis was taken as a measure of the anti-inflammatory activity. The anti-inflammatory activity of the crude ethanol extract, aqueous extract of leaves part of Samadera indica were compared to that of the standard drug diclofenac. The extract in concentration of 250-1000 µg/ml showed a dose dependent inhibition of haemolysis of erythrocyte induced by hypotonic solution. The ethanolic extract of Samadera indica showed significant anti-inflammatory activity in comparison to aqueous extract and with standard drug...
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Posted by admin on Feb 1, 2013 in |
A study was undertaken to evaluate the antioxidant potential of rhizomes of Curcuma amada (Zingiberaceae). Aqueous and ethanolic extracts were subjected to in vitro antioxidant activity screening models such as DPPH, ABTS, nitric oxide and inhibition of lipid peroxidation activity. Ascorbic acid was used as the standard. In all the models studied, both the extracts showed nearly equal activities thereby justifying the traditional claims ofthe...
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Posted by admin on Feb 1, 2013 in |
Granisetron hydrochloride is most commonly used as an antiemetic agent in treatment associated with cancer chemotherapy induced nausea and vomiting. If the dosage form is designed in sustain release it provide more advantage for the antiemetic therapy. The purpose of this research was to study mucoadhesive buccal patches of Granisetron hydrochloride using the bioadhesive polymers chitosan and sodium alginate. Patches containing chitosan in 1.5%w/v and sodium alginate 2%w/v had maximum percentage of in vitro drug release and ex vivo drug permeation upto 8 hr. The swelling index was proportional to chitosan and sodium alginate content. The surface pH of all patches was found to be satisfactory (7.0 ± 1.5), close to neutral pH; hence, buccal cavity irritation will not be a problem with these patches. The mechanism of drug release was found to be Higuchi (matrix). The formulation F6 was optimized based on good bioadhesive strength (326.96±0.99 N/M2) and sustained in vitro drug release (95.81% ± 3.21% for 8 hr), ex vivo permeation (96.59% ± 3.69% for 8 ...
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Posted by admin on Feb 1, 2013 in |
The present study evaluates the reactive oxygen species (ROS) scavenging and in vitro antioxidant activities of two species of Cleome, C. viscosa and C. burmanni. The antioxidant potential of the methanol extracts of species of Cleome was tested using different assays such as FRAP, DPPH, ABTS, hydroxyl, superoxide, nitric oxide, and hydrogen peroxide. The extracts gave positive results for all the assays and the radical scavenging ability was detected to be comparable to those of the corresponding standards. Quantitative estimation of antioxidant phytochemicals, such as phenols, flavonoids and proanthocyanidins were also done in both species of Cleome. The results revealed that the phytochemicals content was greater in C. viscosa when compared to C....
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Posted by admin on Feb 1, 2013 in |
Fatty acid composition of six different leafy vegetables of Bangladesh was investigated. The amount of bound fatty acids was found to be higher than the free fatty acids in all the leafy vegetables. Different fatty acids were identified and their relative proportions were determined by GLC from the leafy vegetables....
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