Posted by admin on Mar 1, 2013 in |
The present investigation highlighted the formulation and release characterization of Ketorolac Tromethamine loaded matrix tablet. Various formulations of tablets were prepared by direct compression method along with Kollidon SR and Hydroxy Propyl Methyl Cellulose (HPMC) as release retardant polymers. Each of the formulated tablets contains 50mg Ketorolac Tromethamine. The evaluation involved physical properties studies (weight variation, thickness, length, width, hardness, friability, and drug content) of tablets and in vitro release kinetics assessment. The USP paddle method was operated at 50 rpm selected to perform the dissolution test and 900 ml phosphate buffer of pH 7.4 was used as dissolution medium. The drug release from each formulation was analyzed by using release kinetics theories. All formulations followed Higuchi release kinetics. When the release data was plotted into Korsemeyer-Peppas equation, then it was confirmed that F-1 to F-5 exhibited fickian type drug release whereas F-6 exhibited non-Fickian type drug release. The in-vitro release studies revealed that the formulation F-4 can be taken as an ideal or optimized formulation of sustained release...
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Posted by admin on Mar 1, 2013 in |
A simple and sensitive UV spectrophotometric method has been developed for the quantitative estimation of trimetazidine in bulk drug and pharmaceutical dosage forms (tablets). Trimetazidine exhibited absorption maximum at 269 nm in 0.1 N HCl and obeyed Beer’s law in concentration range 5-25 µg/ml. The result of analysis in this method has been validated statistically and by recovery studies. This method is extended for the analysis of drug in pharmaceutical...
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Posted by admin on Mar 1, 2013 in |
Solanum sisymbriifolium (Solanaceae) and Jatropha gossypifolia (Euphorbiaceae) have long been used in folkloric medicine for the treatment of various ailments. The purpose of the present study was to evaluate the cytotoxic activity of the plants and to make available the process of data analysis of cytotoxic studies to the researchers. A general toxicity of the extracts was assessed by a simple and low cost assay using brine shrimp lethality as an indicator of toxicity. Ethanol crude extract and fractions of the extract of leaves of Solanum sisymbriifolium exhibited relatively mild cytotoxic activity compared to that of flowers and fruits against brine shrimp larvae with median lethal concentration, LC50 values ranging from 10.10 – 321.35 and 13.19 – 80.16 μg/ml, respectively. Methanol crude extract and fractions of the extract of leaves of Jatropha gossypifolia exhibited significant toxicity against the shrimps (LC50 values 17.19 – 98.19 μg/ml), while that of potassium permanganate, a positive control, was 11.27 μg/ml. Among the fractions of the crude extracts of both plants, non-polar fractions such...
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Posted by admin on Mar 1, 2013 in |
Ficus religiosa L (Moraceae) is widely distributed in northern part of India has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Ficus religiosa L was used for investigation of antiulcer activity by using pylorus ligation as antisecretory model and ethanol induced ulceration models as cytoprotective model. Animals pretreated with ethanolic extract of Ficus religiosa L at the dose 200 mg/kg and 400 mg/kg showed significant decrease in ulcer index and percentage ulcer protection in all models. The results suggested that the extract at 200 mg/kg and 400 mg/kg showed significant protection (P<0.001) by reducing ulcerative lesions when compared with control group of animals. These findings indicate that Ficus religiosa L. bark and rootextract shows significant antiulcer...
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Posted by admin on Mar 1, 2013 in |
A simple and sensitive visible spectrophotometric method is described for the assay of risperidone (RSP) in pure and solid dosage forms. The method involves oxidative coupling of risperidone with MBTH in presence of ferric chloride dissolved in HCl and apple green chromogen is formed and exhibits absorption maxima at 595.8nm. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (10-80) μg/mL. Regression coefficient was found to be 0.992. The proposed method is applied to commercial available tablets and the results are statistically evaluated and validated by recovery studies. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and...
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