Posted by admin on Jan 1, 2013 in |
Background: Oxystelma esculentum is used traditionally as diuretic, laxative, hepatoprotective and anti-ulcer. Objectives: The present work deals with the isolation and structure elucidation of Epicatechin from O. esculentum. Methods: Methanolic extract of the entire plant of O. esculentum was subjected to pilot TLC experiments and column chromatography. Results: This yielded a pure, white compound which resolved at Rf 0.3 on TLC plate using the mobile phase toluene: ethyl acetate (5:4) when developed in iodine chamber. This compound was subjected to UV, IR and 1H-NMR spectral analysis and its structure elucidation revealed it to be Epicatechin. Conclusion: This compound has been reported for the first time in this plant and can serve as a useful tool in its...
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Posted by admin on Jan 1, 2013 in |
Introduction: Solanum nigrum (S. nigrum) has been shown to be hepatoprotective by Ayurvedic physicians but has not been scientifically evaluated so far. So, the present study was undertaken to explore the hepatoprotective activity of S. nigrum against experimentally induced hepatotoxicity in albino rats. Aim of the study: To explore the hepatoprotective activity of S. nigrum. Materials and Methods: Albino Wistar rats weighing 150-200g of either sex were divided into six groups of six animals each. Group I was given normal saline (PO), group II Carbon tetrachloride (CCl4) (IP), group III Liv. 52 syrup for twenty days followed by carbon tetrachloride, group IV, V & VI received aqueous extract of Solanum nigrum ( 2ml/100g/day twice daily) orally for 10, 20 & 30 days respectively followed by CCl4. Blood was collected from anaesthetized animals & liver was dissected out. Alanine transaminase (ALT), alkaline phosphatase (ALP) & Total bilirubin were estimated and liver was subjected to histopathological examination. Results: ALT, ALP & Total bilirubin levels were significantly increased in CCl4 treated group...
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Posted by admin on Jan 1, 2013 in |
The aspire of the present research was to explore the hypoglycemic, analgesic and anti-inflammatory activity of ethyl acetate extract of Peporemia pellucida in alloxan-induced diabetic mice, Acquired immune deficiency syndrome (AIDS), and hypercholesterolemia and against pain. In the present study hypoglycemic effect of the ethyl acetate extract of Peperomea pellucida was significant from (25.35 to 8.1 mM ±SEM) i.e., 68.44% in 300mg/kg ethyl acetate extract as a 7 days hypoglycemic treatment. On 120 minutes OGTT test, reduction of blood glucose level was also significant. In 300mg/kg extract blood glucose level reduced from (20.53mM to 7.69 ±SEM) 62.64% was observed. Analgesic treatment was observed carefully and mentionable activities were evaluated. Percentage of inhibition was 58.16 with the number of writhing 11.8±SEM in 300mg/kg inhibition was observed with 6.8 ±SEM writhing. P. pellucida has significant anti-inflammatory effect after 4 hr with 3.47± SEM. The present study indicates significant hypoglycemic, analgesic and anti-inflammatory effects of P. pellucida. The present investigation established the pharmacological evidence to support the folklore claim and that of...
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Posted by admin on Jan 1, 2013 in |
In the present research work, diethyl malonate and phenyl hydrazine were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro-butyl and 4-nitrooxy-butyl substitution at nitrogen atom. The synthesized products were characterized by physicochemical and analytical means. Few of the synthesized derivatives showed excellent antibacterial and antifungal...
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Posted by admin on Jan 1, 2013 in |
Medicinal plants are extensively used to cure various infectious diseases in human. Our present study was undertaken to investigate antibacterial activity in leaf, stem and root extracts of Acalypha indica against the human pathogens such as Staphylococcus sp, E. coli, Salmonella sp, Klebsiella pneumonia and Pseudomonas. The shade dried leaves, stem and root powder was used to prepare extracts by using and acetone, methanol and ethanol by soxhlet method. The antibacterial activity was studied by using agar well diffusion method with different concentrations of extracts (25, 50, 75 & 100µl). The result showed that ethanol leaf extract is effective against tested pathogen. Highest inhibition of zone was recorded in E. coli ( 22 cm). Phytochemical analysis of Acalypha indica was done. In the present study, the antimicrobial factors of A. indica were found to have Flavonoids, Triterpenoids, Phenolic compounds and proteins in leaf and its molecular weight was found to be 19kDa. Recognition of the molecular factor responsible for bactericidal activity in herbs will pave the way to commercialize...
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