Posted by admin on Dec 1, 2012 in |
Aim of this study was to determine the Antimicrobial, Cytotoxicity and Antioxidant activities of the stem of Ravenia spectabilis. For this study, the dried stem’s powder of Ravenia spectabilis was subjected to cold extraction with methanol and partitioned with n-hexane, carbon tetrachloride and chloroform. The crude methanolic extracts and its n-hexane, carbon tetrachloride, chloroform soluble partitionates, some column fractions and isolated one pure compound (g-fagarine) demonstrated mild to moderate antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria and fungi. The extractives showed significant cytotoxic activity when tested by brine shrimp lethality bioassay. In addition, the extractives also exhibited significant free radical scavenging activity when compared with the standard drug Tert– butyl-1-hydroxytoluene...
Read More
Posted by admin on Dec 1, 2012 in |
In the present study, an effort has been made to evaluate of hydroxypropyl methylcellulose HPMC K15M as rate retardant polymer to sustain the release of Tramadol HCl from Tramadol HCl sustained release tablet matrix. Different amount of HPMC K15M were used in formulation of F1 to F5 where drug and polymer ratio were consequently 5:6, 5:5, 5:4, 5:3 and 5:2 in 200 mg tablet matrix. Tablets were prepared by direct compression. The dissolution study of the tablet matrices of different formulations were carried out in the gastric medium (pH 1.3) for first 2 hours and then in the intestinal medium (pH 6.8) for 6 hours using USP dissolution apparatus II. The drug release patterns were simulated in different kinetic orders such as Zero Order release kinetics, First Order release kinetics, Higuchi release kinetics, Korsemeyer-Peppas release kinetics and Hixson-Crowell release kinetics to assess the release mechanism. From the study it was observed that Zero Order release kinetics was the predominant release mechanism than Higuchi and First Order kinetics. Among the...
Read More
Posted by admin on Dec 1, 2012 in |
The antimicrobial activity of the extracts Basella alba fruit were evaluated by measuring the zones of inhibition using Agar well Diffusion method against eight species of microorganisms: Bacillus subtilus, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Lactobacillus, Klubsiella, Aspergillus niger and Aspergillus fumigatus. The extract showed significant antibacterial activity against Lactobacillus and antifungal activity against Aspergillus fumigates, no activity was found against Klebsiella and moderate activity was observed for all other tested organism. The minimum inhibitory concentration of the extract against bacterial strains was found to be 25mg/ml for Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Lactobacillus, Escherichia coli, Aspergillus niger and Aspergillus fumigates and 50mg/ml for Klebsiella pneumonia. The overall result of this study indicates that the extract from Basella alba fruit have interesting antimicrobial property and thus provide justification for the use of the plants in folk medicine to treat various infectious...
Read More
Posted by admin on Dec 1, 2012 in |
Background: Abortion is the termination of a pregnancy by the expulsion of a fetus or embryo from the uterus. Induced abortion is usually defined as deliberate pregnancy termination prior to 20 weeks (for developed countries) and 28weeks (for developing countries) gestation. Describing the determinants of induced abortions contributes for long lasting reduction of induced abortion. Objective: The aim of this study was to describe determinants of induced abortion among women of child bearing age, which experienced abortion, attending maternal and child health clinic in Mekelle town, Ethiopia. Method: Institutional based cross sectional study was employed and 260 study subjects were selected using convenient sampling technique, and the data was collected using interviewer administered structured questionnaire; data was analyzed and cleaned using SPSS version 16. Binary logistic regression analysis was carried out to see determination of variables. Results: Majority of women who had experienced induced abortion 138 (53.1%) were under the age of 25 years, with mean age 26.22 ±7.01years. A large number, 105 (40.4%) were with secondary school and...
Read More
Posted by admin on Dec 1, 2012 in |
Chronic Obstructive Pulmonary Diseases (COPD) refers to multiple lung diseases, is the occurrence of chronic bronchitis and emphysema, a pair of commonly co-existing diseases of the lungs in which the airways become narrowed because of inflammatory cells like neutrophils, CD8 cells and macrophages. These cells produce the Matrix metalloproteinases (MMPs), cathapsins and other proteinase enzymes. In humans there are 26 MMPs are present, which are classified in to six categories based on the structure of their substrate, sequence similarity and characteristics of structural domain. Structurally, MMPs are similar, but functionally different – but the general function of MMP is to degrade the extracellular matrix according their specific substrates. From the literature, three MMPs [MMP-09, MMP-12 & MMP-14] which are implicated in COPD were selected. Our aim is was to achieve a meaningful understanding of selectivity of individual ligands towards their enzymes, while our interest also is to find explanations for selective and non-selective...
Read More
