Posted by admin on Jan 1, 2013 in |
The present study was designed to investigate the antihyperglycemic activity of chitosan of Podophthalmus vigil on normal and streptozotocin (STZ) diabetic rats. Diabetes was induced into male albino wistar rats by intraperitonial administration of STZ. Chitosan was administered orally at three different doses to normal and STZ-diabetic rats for 30 days. The diabetic rats showed an increase in levels of blood glucose and glycosylated hemoglobin (HbA1c) and a decrease in the levels of insulin and hemoglobin addition, diabetic rats showed a significant reduction in the activity of glucokinase and an elevation in the activities of gluconeogenic enzymes such as glucose-6-phosphatase and fructose-1, 6-bisphosphatase. Treatment with chitosan significantly decreased plasma glucose and HbA1c, and increased the insulin and Hb. Chitosan administration to diabetic rats reversed these enzyme activities in a significant manner. Thus, the results show that chitosan possesses an antihyperglycemic activity in the control of diabetes. The 300 mg dose of the extract produced a better effect than 100 and 200 mg...
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Posted by admin on Jan 1, 2013 in |
Administration of ethanol extract of Polygala chinensis whole plant (100 mg/kg and 200 mg/kg body weight) to alloxan induced diabetic rats for 14 days reduced the elevated level of lipid peroxidation (LPO). The treatment also resulted in significant increase in reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) in serum, liver and kidney. The results confirm the antioxidant activity of P. chinensis whole plant and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic...
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Posted by admin on Jan 1, 2013 in |
The aim of present study was to formulate and evaluate probiotic tablets containing anti-inflammatory drug Mesalazine. Matrix tablets were prepared using Sodium alginate and Hydroxypropylmethylcellulose acetate succinate (HPMCAS) as matrix forming components, with three different combinations by wet granulation method. The granules were evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausners ratio. The tablets were subjected to weight variation, hardness, friability and drug content test and invitro release studies. Additionally the tablets were tested for contents of viable cell counts of probiotic lactobacilli using standard plate count (SPC) method. Invitro release studies revealed that all formulations qualified both stages for release of the drug i.e. acid stage and buffer stage 1. The release profiles were affected by variable concentrations of sodium alginate when combined with HPMC-AS. The combination at 1:2 (SA2) prevented the escape of both actives more effectively than the other two formulations at all the three stages of dissolution test. A few numbers of bacterial cells were lost in acid stage as...
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Posted by admin on Jan 1, 2013 in |
Preliminary phytochemical investigation of various extracts of leaves of Corchorus aestuans Linn showed the presence of flavonoids, carbohydrates, saponins, phytosterols, phenolic compounds, triterpenoids, cardiac glycosides and tannins. An attempt has been made to isolate flavonoids and perform antioxidant potential of the same. The antioxidant activity was performed by two in-vitro testing methods, such as scavenging activity on 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals and hydroxyl radical scavenging activity by EDTA. The data obtained in these testing systems clearly established the antioxidant potency of Corchorus aestuans...
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Posted by admin on Jan 1, 2013 in |
Ethnobotanical study was conducted in district Rajouri, Jammu And Kashmir State aiming at identifying plants used to treat chest diseases mainly related to respiratory system. A semi-structured questionnaire was used to interview members of the tribal population including traditional healers, herb sellers, and other villagers. The plant parts used as well as the modes of preparation and administration were recorded. Thirty one plant species belonging to twenty four families were collected and identified by their vernacular and scientific names. The Asteraceae, Acanthaceae, Pinaceae were the most represented family with three species each, followed by the Anacrdiaceae, Euphorbiaceae and Fabaceae with two species each. All the remaining 15 families were represented by one species each. The plant part most frequently used to treat respiratory diseases in the study was reported as Root followed by leaf, flower, fruit, bark and seed. Also many other plant parts including rhizomes, galls, buds, resins and latex were found in use in various formulations for chest diseases...
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