Posted by admin on Dec 1, 2012 in |
Chronic myeloid leukemia (CML) is a malignancy of hematopoietic stem cells associated with a t(9;22) translocation that forms the Philadelphia chromosome and creates a novel fusion gene, BCR-ABL. For those who are resistant or intolerant to imatinib, second-generation tirosino-kinase inhibitor, as dasatinib, has been shown to be efficacious in all phases of the disease. Once dasatinib is taken orally and the treatment has no defined end point, a complete follow up method, including a pharmacotherapy follow up, to monitor the CML patients is essential to define adherence and treatment safety. To systematically review follow up methods of CML patients treated with dasatinib in clinical trials (CT) either randomized (RCT), or not (NRCT) and prospective cohorts (PC) a sensitized research was performed on the databases Medline (Pubmed), Cochrane Library (OVID), Embase (Elsevier) and Lilacs. Four RCT, four NRCT and three PC were identified and contained data about patients follow up, which proved to be well established and structured. Adverse drug reactions grades III and IV description was in accordance with...
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Posted by admin on Dec 1, 2012 in |
Tuberculosis (TB) is a growing international health concern and it is estimated that a third of the world’s population is currently infected with TB. The increasing prevalence of multidrug-resistant (MDR)-TB has greatly increased difficulties in its treatment and control. Therefore, the present study was perceived to check the status of tuberculosis at Kanpur, one of the largest city of Uttar Pradesh and oldest industrial townships of North India. Study was also aimed to understand the expectation and mindset of community/patients regarding the services of a pharmacist in the maintenance or restoration of health. The study was conducted on the TB patients attending different outpatient and or inpatient department of local and government hospital, clinics, in Kanpur city and necessary information had been collected through questionnaire by making couple of visit and follow-up counseling. It was amazing to know through the study that knowledge and awareness about such common and chronic diseases was either very poor or there was none implementation for prevention and control. The healthcare services of pharmacist...
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Posted by admin on Dec 1, 2012 in |
Co(II), Ni(II) and Zn(II) complexes of Schiff bases derived from condensation of 4-anisaldehyde with anisidine, (AAN) or 2,4 dinitrophenylhydrazine ,(ADN) have been prepared in 1:2 molar ratio (metal:ligand). The compounds have been characterized using elemental analysis, electronic spectra, infrared and molar conductance measurements. The infrared data revealed that the ligand, AAN behaved as a tridentate ligand. It coordinated to the metal ions via the N and two O atoms of the ligand. ADN behaved as a bidentate ligand coordinating through the O and N atoms of the ligand. The electronic spectral data indicates that the compounds are six coordinate. The molar conductance values showed that the complexes are non-electrolytes. The compounds were screened in vitro for antibacterial activity against some pathogenic bacteria: Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Bacillus subtilis and Staphylococcus aureus using the agar-well diffusion method. The synthesized Schiff base complexes exhibit higher antibacterial activity against the tested pathogens compared to the free Schiff base because of...
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Posted by admin on Dec 1, 2012 in |
A new spectrophotometric method is developed for the determination of artesunate (ARTS) in pharmaceutical preparation and bulk drug. The method involved heat-catalyzed derivatization of the drug with acetic anhydride and concentrated sulphuric acid producing a yellow coloured product peaking at 420.6 nm. The optimum conditions of the reaction and the analytical procedures of the assay were established. Under the optimum conditions, linear relationship with good correlation coefficient (0.9994) was found between the absorbance and the concentration of ARTS in the range of 4 – 60 µg mL-1. The limit of detection was found to be 0.72 µg mL-1 and quantitation limit was 1.8 µg mL-1. The analytical performance of the method was validated and the results were satisfactory. The developed method was successfully validated and applied for the determination of artesunate in bulk and pharmaceutical formulation without any interference from common...
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Posted by admin on Dec 1, 2012 in |
In the present study, an attempt has been made to formulate and evaluate orodispersible tablets of meclizine hydrochloride by using direct compression via employing different excipients in different ratio including: superdisintegrants {sodium starch glycolate (SSG), crosscarmellose sodium (CCS), crosspovidone (CP), and microcrystalline cellulose (MCC)} which were used alone and in combination, solid dispersion of MHCl in microcrystalline cellulose, diluents: lactose, granulated lactose, and mannitol, along with lubricant and glidants. The prepared formulas were evaluated for pre and post compression parameters including bulk density, tapped density, Carr’s index, angle of repose, weight variation, thickness, friability, hardness, in vitro disintegration and dispersion time, wetting time, and water absorption ratio. The formulas containing granulated lactose (as diluent) showed good flow properties. Increasing concentration of three superdisintegrants (CP, SSG, and CCS) was accompanied with an increase in disintegration time (DT) while the disintegration time was decreased with an increase in concentration of MCC. Depending on the obtained results, formula 11 (F11) which contains 4% W/W CP, 10% W/W MCC was selected as an...
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