Posted by admin on Dec 1, 2012 in |
Water soluble polymers such as Hydroxy Propyl Methyl Cellulose (HPMC), Poly Vinyl Pyrrolidone (PVP), Carboxy Methyl Cellulose – Sodium (CMC – Na), and Methyl Cellulose as well as in combination of varying proportions are used in this study for the protective coating of Microcrystalline Hydroxy Apatite Complex (MCHC). The objective of this study was to investigate the effect of aqueous film coating on MCHC tablets evaluated by comparison with plain MCHC tablets and non-aqueous coated tablets. The parameters evaluated were the film smoothness, shininess, coating uniformity, percentage weight increase, hardness, disintegration time, dissolution study, moisture adsorption, stability and toxicity. An aqueous film coating solution in different combinations was applied on the tablets using a laboratory coating pan at 60oC, in the atmospheric pressure. By using the same method non aqueous film coating solution was applied on the MCHC tablets and the tablet bed temperature maintained at 40oC. The study has shown that HPMC and PVP combination in the proportion of 5% and 1% as coating material gave promising results...
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Posted by admin on Dec 1, 2012 in |
n-octacosanol is an normolipidemic aliphatic primary alcohol obtained from the plant Tinospora cordifolia Miers. In the present study, the plant stems were collected from five accessions namely Anniyalam, Chennai, Hassan, Vishakhapatnam and Bangalore between June and August. Later a simple HPTLC method has been established for determination of n-octacosanol in methanolic extracts of all these geographical sources using Toluene: Ethyl acetate: Formic acid (4.5:4.5:1 v/v) as mobile phase. Detection and quantification were performed by densitometric scanning at λ = 555 nm. The results of HPTLC estimation showed variation in n-octacosanol content in all the accessions. The extract from Anniyalam accession showed significantly higher amount of n-octacosanol (6.54%) and that of Vishakhapatnam showed the least (2.28%). Thus, the present work is helpful in selecting genotype of Tinospora cordifolia yielding highest percentage of...
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Posted by admin on Dec 1, 2012 in |
A new, selective and sensitive visible spectrophotometric method has been developed for the estimation of Ketorolac tromethamine in bulk and pharmaceutical preparations. The method is based on the reaction of ketorolac tromethamine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone (DDQ) to form red color charge–transfer complex with a λmax. 460nm extracted in methanol. Beer’s law is obeyed in the concentration range of 50 to 250µg/ml for the method. The method is extended to pharmaceutical formulations and there was no interference from any common pharmaceutical excipients and diluents. The result of analysis has been validated statistically and by recovery...
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Posted by admin on Dec 1, 2012 in |
The main cause of increasing of infectious diseases cases is due to multidrug-resistant microorganisms emergence, particularly Pseudomonas aeruginosa and Staphylococcus aureus, responsible for most of hospital-acquired infections and millions deaths related. Despite development of new antibiotics, control of these microorganisms is not always successful. Several plant extracts have demonstrated antimicrobial effects and may be used as an alternative therapy for these infections. Aiming to evaluate antibacterial activity of extracts from Eleutherine plicata (marupazinho), Geissospermum vellosii (pau-pereira) and Portulaca pilosa (amor crescido) against multidrug-resistant bacteria, samples of Oxacillin-Resistant Staphylococcus aureus (ORSA) and multidrug-resistant P. aeruginosa (MDR P. aeruginosa) isolated from human clinical processes were tested. The antibacterial activity was determined by disk diffusion method and minimum inhibitory concentration (MIC) by microdilution method. Extracts and fractions were tested at concentrations of 500, 250, 125, 62.5, 31.2 and 16.2 µg/mL dissolved in DMSO 10%. E. plicata and G. vellossi have shown activity against ORSA at MIC of 125 µg/L, whilst P. pilosa have shown action on MDR P. aeruginosa at MIC of...
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Posted by admin on Dec 1, 2012 in |
Esomeprazole is a proton pump inhibitor which reduces gastric acid secretion through inhibition of H+/K+-ATPase in gastric parietal cells. By inhibiting the functioning of this enzyme, the drug prevents formation of gastric acid. Esomeprazole is combined with the antibiotics, clarithromycin and amoxicillin (or metronidazole in penicillin-hypersensitive patients) in the 7-14 day eradication triple therapy for Helicobacter pylori. Infection by H. pylori is the causative factor in the majority of peptic and duodenal ulcers. Common side effects of Esomeprazole include headache, diarrhea, nausea, gas, decreased appetite, constipation, dry mouth, and abdominal pain. More severe side effects are severe allergic reactions, chest pain, dark urine, fast heartbeat, fever, paresthesia, persistent sore throat, severe stomach pain, unusual bruising or bleeding, unusual tiredness, and yellowing of the eyes or skin. Proton pump inhibitors may be associated with a greater risk of hip fractures and Clostridium difficile– associated diarrhea. Patients are frequently administered the drugs in intensive care as a protective measure against ulcers, but this use is also associated with a 30% increase...
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