Posted by admin on Nov 1, 2012 in |
Privatizations of health care have changed the functioning and demand of health care system. As today’s competitive environment leaves no scope for error, we need to delight our patients, look for new ways to exceed their expectations on continuous basis, with a focus on improvement in technical skills, human skills and to develop cost effective methodologies. To meet challenges, implementation of six sigma is the utmost solution. The concept is still in its nascent stage in Indian health care system. Six sigma is a scientific concept, provides measurement of every activity in the hospital by using various statistical tools. Alternatively delay in discharge of patients was a chronic problem among Indian Hospitals. Good discharge management is vital to ensure patient satisfaction; bed availability for emergency and elective admissions; and quality of patient care remains high. This paper attempts to study six sigma aspects in the discharge process of a corporate...
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Posted by admin on Nov 1, 2012 in |
Gastric residence time of oral controlled release system such as microspheres is increase by different techniques such as floating and mucoadhesive system. The objective of present investigation was to formulate floating microspheres of Nateglinide in order to increase gastric residence time, increased bioavailability and to reduce dose frequency of drug molecule. Novel o/w emulsion solvent diffusion technique was used to prepare microspheres of Nateglinide by using various polymers such as HPMC, Ethyl cellulose and Eudragit S100. Entrapment efficiency of drug was upto 69%. Eudragit S100 based microspheres which were found to be hollow cavity, spherical and porous nature from the results of scanning electron microscopy. Micromeritic profile of prepared microballoons was found satisfactory. From the results of FTIR spectroscopy it was reveal that there is no drug- polymer interaction. Eudragit S100 based microspheres shows good in vitro buoyancy and sustained release profile for longer period of time > 14 hours. The formulation had followed first order kinetics as its release mechanism was diffusion...
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Posted by admin on Nov 1, 2012 in |
The objective of the study was to examine the influence of two variables, concentration of the matrixing agent and diluent on the release of diclofenac sodium from hydrophobic matrix tablets. A 32 full factorial design was employed to optimize drug release profile. Concentration of the hydrophobic matrixing agent (X1) and type of diluent (X2) were taken as independent variables. The dependent variables selected were percentage drug release at 3h, 6h, 9h, time required for 50% drug release and zero order rate constant. Matrix tablets were evaluated for hardness, friability, weight variation and in vitro drug release. Polynomial equations and response surface plots were generated for all dependent variables. It was observed that all the factors had significant contribution on all dependent...
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Posted by admin on Nov 1, 2012 in |
A Simple, Fast and Reliable UV Derivative Spectrophotometric Method was developed and Quantitative Estimation of Metaxalone and Diclofenac potassium in Pharmaceutical Dosage Form was carried out using the First Derivative values measured at 276 nm for Metaxalone and 270 nm for Diclofenac potassium. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Metaxalone using 80-800 µg/ml and 10-100 µg/ml of Diclofenac potassium for First Derivative Spectrophotometric Method and the correlation coefficient was found to be 0.9986 and 0.9982 respectively. Precision study showed that the % RSD was within the range of acceptable limits (< 2), and the % Recovery was found to be in the range of 99-100% for Metaxalone and 100-101% for Diclofenac potassium. Developed Spectrophotometric Method in this study was Simple, Accurate, Precise, Specific, Sensitive, Reproducable and can be directly and easily applied to Pharmaceutical Dosage...
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Posted by admin on Nov 1, 2012 in |
The aim of this work is to determine the cytotoxic activities of Terminalia arjuna (Family: Combretaceae) by brine shrimp lethality bioassay. The leaves of Terminalia arjuna were extracted with methanol and the methanolic extract was fractionated into three fractions by using organic solvents like n-hexane, ethyl acetate and chloroform. The n-hexane, ethyl acetate and chloroform soluble fractions of methanolic crude extract were screened for antitumor properties using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it could be well predicted that n- hexane, ethyl acetate and chloroform soluble fractions of Terminalia arjuna leaves possess cytotoxic principles (LC50 1.29 µg/mL, 1.5 µg/mL and 1.23 µg/mL respectively) comparison with positive control, vincristine sulphate (LC50 0.563...
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