Posted by admin on Jan 1, 2013 in |
Parthenium hysterophorus L. is commonly known as “Gajar ghas” in Hindi and belongs to family Composite. It is an annual herb erect up to 1.5 m in hight. Its stems is branched and covered with trichomes. Its leaves are pale green, branched and covered with soft fine hairs. In Homoeopathy system, allergies caused by Parthenium can be treated by a drug prepared from Parthenium. Root decoction is useful in dysentery. In the present paper, we report the isolation and structurel elucidation of a new allelochemical identified (I) as 3 , 5, 7, 4′ tetrahydroxy-3′-methoxyflavone-3-O-b-L-galactopyranosyl-(1→3)-O-b-D-arabinopyranosyl-7-O-a-L-rhamnopyranoside alongwith two known compounds Lutexin (II) and Cirsilineol (III) from methanolic extract of the stems of this plant by several colour reactions, chemical degradations and spectral...
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Posted by admin on Jan 1, 2013 in |
The seaweeds are economically valuable resources, used as food, fodder, fertilizer and medicine and thus useful to mankind in many ways. In the present study, Kappaphycus alvarezii, a marine alga, has been analysed for the presence of bioactive products using three solvent extracts. Antimicrobial activity was also done using the same extracts of seaweed. The results revealed that the selected seaweed has active secondary metabolites and also exhibited antimicrobial activity, mainly in the methanolic extract of Kappaphycus...
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Posted by admin on Jan 1, 2013 in |
A simple, precise, accurate, rapid and reproducible RP-HPLC method has been developed for the determination of Nitazoxanide in powder for suspension dosage form. Chromatography was carried out on an ODS C18 column (250 x 4.6 mm x 5 µm length), using a mixture of acetonitrile and 0.005 mol L-1 tetra n- butyl ammonium hydrogen sulphate (54:46 v/v) as the mobile phase at a flow rate of 1 mL/min and the detection was done at 240 nm. The method produced linear responses in the concentration range from 50 to 150 µg/mL of Nitazoxanide with correlation coefficients of 0.999, accuracy of 98.90% and precision of 0.811%. The method was found to be reproducible for analysis of the drug in suspension dosage form. The results of the analysis were tested and validated statistically for various parameters according to ICH guidelines and recovery studies confirmed the accuracy of the proposed...
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Posted by admin on Jan 1, 2013 in |
Since plants are used as therapeutic agents, the present study was conducted to evaluate the antibacterial activities of methonolic extracts of different components of Citrus hystrix and Citrus maxima (Red and White) fruit. Studies on the antibacterial activity of methanolic extracts of leaf, peel, and pulp of Citrus hystrix and Citrus maxima (Red and White) fruitwas conducted using agar disc diffusion method. The microorganisms used include Staphylococcus aureus (MTCC 3160), Salmonella typhi (MTCC 3215), Escherichia coli (MTCC 40), Pseudomonas aeruginosa (MTCC 424), Klebsiella pneumoniae (MTCC 3384). The maximum activity was observed against all organisms except Pseudomonas aeruginosa and Klebsiella pneumoniae. The minimum inhibitory concentration ranged between 12.5mg/mL and 200mg/mL depending on microorganism and various extract. Citrus hystrix and Citrus maxima (Red and White) fruit were observed to have antibacterial activity and can be used for medicinal...
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Posted by admin on Jan 1, 2013 in |
The objective of the work was to design oral FDFs of a drug meant for management of chronic disease like type-2 diabetes mellitus which affects mostly elderly population. Glimepiride was the drug of choice because of its low dose. Since in vitro dissolution rate is the rate limiting step in drug absorption for class II drugs, in the present work,it was also proposed to make a complex of the drug with hydroxypropyl betacyclodextrin (HPBCD) to improve the physicochemical-pharmacokinetic characters of the drug. Various batches of FDFs were developed by the solvent casting method using water soluble polymers HPMC-E5 and Maltodextrin as film formers; Glycerol and PEG-600 as plasticizers; Sodium starch...
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