Posted by admin on Nov 1, 2012 in |
Osteoarthritis (OA) is disabling condition leading to loss of articular cartilage. Etiology of OA is not clearly understood and diagnosis of early stages of OA is difficult due to lack of specific markers. Recent literature suggest that elevation of Myeloperoxidase (MPO) levels in synovial fluid in early stages of OA as compared to controls and late stage OA. Presence of MPO in blood and Urine samples of OA patients is still not studied. Present study is designed to explore the role of plasma and urine MPO levels in different stages of osteoarthritis. Based on Kellgren-Laurence (K.L.) Score, study subjects were divided into 4 groups as per 4 grades of severity of OA. These assignments were made by experienced joint surgeons and were based on radiographic & clinical findings. MPO levels in plasma and urine is estimated by ELISA technique. Levels of Plasma and Urine MPO are found to be significantly higher in case Grade 1, grade 2(Early Knee OA) & MPO level goes on decreasing in Grade 3 &...
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Posted by admin on Nov 1, 2012 in |
Gastro-intestinal (GI) toxicity is the common adverse effect which has been associated with most of NSAIDs available in the market. So the search for new therapeutic agents with high margin of safety and freedom from normally associated GI toxic effects has been a priority of pharmacologists and pharmaceutical industries. There are virtually limitless series of structurally novel heterocyclic compounds with a wide range of physical, chemical and biological properties. Literature survey reveals that coupling of two or more biodynamic molecules resulted in the enhanced biological activity. The present work embodied here involves synthesis and evaluation of analgesic and anti-inflammatory activities of some bis (indolyl) methane...
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Posted by admin on Nov 1, 2012 in |
The aim of this study was to investigate the possibility of gastric-ulceration by ginger-juice (Zingiber officinale Roscoe) in rat. (A) Albino rats (n=6-12) were administered G.J at two doses (2ml & 4 ml/rat, p.o) as single administration and chronic treatment over period of 30 days. Following this assessment was done for possible gastric lesion. Effect of treatment with G.J acutely and chronically (30 days) administered, was assessed. Parameters used during assessment were total acidity, gastric volume & pH and ulcer index ‘UI’ (acute and chronic). Acute & chronic administration of G.J (2ml & 4ml/rat, p.o) caused an increase in pH and vol. of gastric content, a decrease in total acidity and no significant change in ulcer...
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Posted by admin on Nov 1, 2012 in |
Waste is anything, which is not used by any owner, producer and processor, even though it has always been a part of the earth’s ecosystem. Enriched Soil is a good source for the isolation of power full and potential microorganisms which produces specific enzymes which target the waste and in turn produces pharmacologically viable products; Microbes hold this prominent position because of their diversity and proven ability to produce new enzymes which is capable of degrading the waste from various industries. In this study we have concentrated on Fruit, coconut, leather, poultry, and paper industrial waste. Vellore is a Industrial developing medium city surrounded by three states Andhrapradesh ,Tamilnadu and Karnataka and the soils are highly enriched with industrial waste the studies in this direction is rudimentary and hence this study proves the pivotal role on enriched soils in screening of potential microbial enzymes which are used in various pharmacy...
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Posted by admin on Nov 1, 2012 in |
Aim: The aims of this study were to develop liposome enriched Dexibuprofen liposomal hydrogels for topical delivery, perform in vitro release studies and in vivo permeation studies through mice/rat skin, and evaluate the efficacy of liposomal gels against inflammation induced rats. The purpose was to provide the delivery of the topical drug at a sustained rate across intact skin to improve bioavailability and inflammation control for longer period from liposomal gels. Method: Phosphatidylcholine, Cholesterol and Dexibuprofen were dissolved in chloroform/methanol (2:1, v/v) mixture and subsequently transferred into a pear-shaped flask connected to a Rotavapor (Büchi- type). Rotary evaporation method was used for the formulation of liposomes. Result: liposome prepared was evaluated for particle size measurement, percent drug entrapment, diffusion study, skin permeation study and in vivo study. F-7 batch found to be optimized batch having particle size 5.40 µm, % drug entrapment 61.70, % CDR 75.35 %. Hence F-7 batch further evaluated for skin permeation study, skin deposition study, in vivo study and stability study. Conclusion: The present study...
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