Posted by admin on Oct 1, 2012 in |
The purpose of the study was to design and evaluate fast dissolving carvedilol tablets using β-Cyclodextrin and superdisintegrants adopting sublimation technique. Tablets were prepared by direct compression method. Tablets were evaluated for their physico chemical properties, wetting time, disintegration, in-vitro release and stability studies. SEM analysis was carried out to determine the surface characteristics of solid dispersions. Precompressional studies revealed good micromeritic properties of powder blend for direct compression. The hardness (3.9-4.3 kg/cm2), friability (0.35-0.51), drug content (96.58-99.43 %) and disintegration time (44.05-66.21 sec) of fast dissolving tablets were found uniform and reproducible. Dissolution of tablets was directly proportional to the superdisintegrants concentration. Selected tablet (F1) was found superior than any other formulations with respect to disintegration and dissolution...
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Posted by admin on Oct 1, 2012 in |
The aim of the present study is to formulate and evaluate taste masked Almotriptan orally disintegrating tablet by using different taste masking agents and different superdisintegrants in different ratios, Almotriptan is a triptan class anti-migraine drug with rapid action, highest bioavailability and low side effects compared to other triptan class of drugs used in the treatment of migraine, Thus formulating Almotriptan as an orally disintegrating tablet is extremely advantageous. However due to its bitter taste formulating Almotriptan into an orally disintegrating tablet is a challenge. Two taste masking agents namely Eudragit EPO and Precirol A To5 are used to taste mask the drug. The oral disintegrating tablets of Almotriptan were prepared using different superdisintegrants and the effect of different superdisintegrants at different concentration on in-vitro release was studied. Almotriptan release from ODT was directly proportional to the concentration of the superdisintegrant used. The optimized formulation was found to release the drug in minimum time and is found to be...
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Posted by admin on Oct 1, 2012 in |
A simple, precise and accurate UV spectrophotometric method has been developed and validated for the estimation of Telmisartan in bulk and tablet dosage form. The spectra of Telmisartan in 0.1 N NaOH and distilled water (20:80) shows λmax at 234 nm and estimation was carried out by A (1% 1cm) and by comparison with standard. Calibration graph was found to be linear (r2= 0.999) over the concentration range of 2-10 μg/mL. The proposed method was validated for its accuracy, precision, specificity, ruggedness and robustness. The method can be adopted in its routine...
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Posted by admin on Oct 1, 2012 in |
Investigations into the larvicidal potential of crude extracts of ten Nigerian plants were carried out against the fourth instar larvae of Anopheles gambiae mosquito. The phytochemical screening revealed that both anthraquinones and cyanogenic glycosides were absent in all the plants. However, alkaloids, saponins, tannins, cardiac glycosides, terpenes and flavonoids were either present or absent. The larvicidal activity expressed as % LA was concentration and incubation-time dependent. At 5%w/v (12 and 24h), only Carica papaya and Dacryodes edulis demonstrated remarkable larvicidal activity of 40% and 55% and 50% and 70% respectively while the rest were largely inactive. However, at 10%w/v (12 and 24h), seven of the ten plants namely; Antholeisia djalonensis (60% and 80%), Calotropis procera (50% and 70%), Carica papaya (70% and 80%), Cyathula prostrata (37% and 67%), Dacryodes edulis (90% and 100%), Pycanthus angolensis (45% and 50%) and Viscum album (33% and 73%) gave comparably stronger activities especially after 24h incubation time. This study indicates a potential use of these plants in the control of vector mosquitoes which...
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Posted by admin on Oct 1, 2012 in |
Glossocardia bosvallia DC.1-3 belongs to family Composite which is commonly known as “Patthar-suva or seri” in Hindi. It is found almost throughout in India and Deccan Peninsula. It is a small annual herb, 10-20 cm tall. The tribal inhabitants of western Maharashtra use a decoction of the plant as febrifuge. It has a bitter taste and fennel like odor. Besides serving as a medicinal plant Pithari plant is also used in culinary purposes. In the present paper, we report the isolation and structural elucidation of a new allelochemical 5,6,7,4′, tetrahydroxy 3-methoxy flavone -7-O-b-D xylopyranosyl (1→4)-O-b-D- glucopyranoside (A) which showed antiviral activity , alongwith two known compounds 6, 4΄-dimethoxy-5, 7-dihydroxy-flavone (B) and Isoorientin (C) from methanolic extract of the stems of this...
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