Posted by admin on Nov 1, 2012 in |
The objective of this study is to evaluate the analgesic and anti-inflammatory activities of the Caesalpinia bonducella in animals. The analgesic action was evaluated in rats using the acetic acid-induced writhing test and the hot-plate test. The anti-inflammatory activity was estimated using carrageenan-induced paw edema in rats. Caesalpinia bonducella strikingly and dose-dependently suppressed carrageenan-elicited paw edema in rats, inhibited the writhing response in rats, increased reaction time of in the hot-plate test. These findings propose that aqua of Caesalpinia bonducella seed has evident non-central analgesic and anti-inflammatory...
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Posted by admin on Nov 1, 2012 in |
The present study deals with the antibacterial activity of Acetone, Dichloromethane, methanol extracts of the tuber and seed of Gloriosa superba L. (Liliaceae) using disc diffusion method against human pathogens, such as Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeurognisoa, Staphylocuccus aureus. In the present investigation all the extracts were found to be effective against five human bacterial species. The Dichloromethane extract showed greater activity against Proteus...
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Posted by admin on Nov 1, 2012 in |
Food and nutrients play vital role in normal functioning of the body. The samples selected for this study were Ethanolic extract of Red grape seed, Ethanolic extract of green tea leaves, Commercially available grape seed extract / Isotretinion tablet, green tea extract , Vitamin A and E tablets. The Nutraceutical effects of grape seed extract and green tea extract was analyzed. The antimicrobial activity of all the above samples were studied by disc diffusion method against Pseudomoas spp., Flavobacterium spp, Aeromonas spp., Enterobacteriaceae, E. coli, lactobacillus spp., and staphylococcus spp. The antibiotic tetracycline disc used as a standard. All samples had been found to contain potent antimicrobial activity. The antioxidant activity was measured by DPPH method and compared with vitamin A and vitamin C. Both the prepared and commercially available extracts obtained more antioxidant activity than vitamin A & C. Thus the results showed that the grape seed extract and green tea leaves has antioxidant and antimicrobial...
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Posted by admin on Nov 1, 2012 in |
Background: Diabetes is a group of metabolic disorders that affect the body’s ability to process and use sugar (glucose) for energy. Type 2 diabetes mellitus resulting from the combination of resistance to insulin action and inadequate insulin secretion. The success of long-term maintenance therapy for diabetes depends largely on the patients’ adherence with self-care practices. Objective: The aim of this study was to assess diabetes self-care practices and associated factors among type 2 diabetic patients in Tikur Anbessa Specialized Hospital, Ethiopia. Method: institutional based cross sectional study was employed and 320 study subjects were selected using systematic random sampling technique. And the data was collected using interviewer administered structured questionnaire; data was analyzed and cleaned using SPSS version 16. Scoring method was employed to classify patients’ self-care practice level as adhered or not adhered to self-care practices. Results: Of all respondents 167(52.2%) female. Mean age of the respondents was 55.03±10.7 years with minimum age of 30 and maximum age of 85. The mean duration of diabetes was 12.3±7.6years with...
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Posted by admin on Nov 1, 2012 in |
Glibenclamide is practically insoluble in water and its gastrointestinal absorption is limited by its dissolution rate. Therefore, to enhance the drug dissolution and its hypoglycemic effects, the drug was formulated in different microemulsion systems and in vitro/in vivo evaluated. Microemulsion systems were prepared by Water titration method in which surfactants and cosurfactants (S/CoS) were mixed at different weight ratios of 1:1, 2:1 and 3:1. They were subjected to transmission electron microscopical examination, pH determination and viscosity tests. The solubility of Glibenclamide in different microemulsion systems was determined. Forms 8, 9, 10, 11, 14 and 18 were found to have high Glibenclamide solubility using different oils. Form 11 and 9 showed the highest Glibenclamide release rates of 59.72% and 52.35%, respectively after 6 hours. In-vivo studies were tested using diabetic rats by application of form 11 with n-butanol as cosurfactant transdermally and form 8 with propylene glycol cosurfactant orally and transdermally. The results were compared to the drug suspension as a positive control. It was shown that microemulsion systems gave...
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