Posted by admin on Oct 1, 2012 in |
The objective of the present study was to prepare a matrix tablet for colon targeting. Natural gaums (guar gum and xanthan gum) were used for the preparation of colon targeted drug delivery system. Different concentrations of guar gum and xanthan gum and their combinations were tried for the purpose. The prepared tablets were evaluated for in-process parameters as well as colon targeting characteristics. The colon targeting properties were evaluated by analysing the formulations for drug release in physiological pH medium of colon. All the formulations were found to be suitable in in-process quality control parameters. The guar gum and xanthan gum were used from 10% to 30% concentration in the formula. The third series of formulations contained guar gum and xanthan gum combinations in ratios of 10% and 20%, 20% and 10% and 15% and 15% respectively. The drug release was found to be 82% to 100% for guar gum formulations, 85% to 99% for xanthan gum formulations and 87% to 100% for the combination of xanthan gum and...
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Posted by admin on Oct 1, 2012 in |
A new, simple and rapid reversed-phase high-performance liquid chromatography (HPLC) method was developed and validated for the determination of some azoles drug (Ketoconazole, Isoconazole and Miconazole) in pharmaceutical dosage forms in Jordan market. The HPLC separation was achieved on a C18 BDS column (100 mm × 4.6 mm) using a mobile phase of acetonitrile and 0.05 M Ammonium Acetate buffer (70:30, v/v) that adjusted to pH 6 using phosphoric acid at a flow rate of 1 mL min−1 and using UV absorbance detection at 254 nm. The method was validated for specificity, linearity, precision, accuracy, robustness. The separation was completed within 11.77 minutes and the assay was linear over the concentration range of 50% to 150% (r2 = 0.9999), the percent recovery for test and reference formulation was...
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Posted by admin on Oct 1, 2012 in |
Background: Following the Alma-Ata Declaration of 1978, the World Health Organization (WHO) began the issuance of guidelines for developing standardized herbal preparations from Traditional Medicine (TM). Similarly in 1987, the International Organization for Standardization (ISO) launched the most anticipated industrial standard (ISO 9001) in world history. The seventh (7th) clause of ISO 9001’s eight clauses is devoted to “Product Realization”- a quality management system (QMS) procedure that includes: planning of product realization; appreciation of customer-related processes; design and development processes; purchasing; production and service provision; and control of measuring and monitoring equipment. Purpose: The article takes a hard look at the QMS processes involved in product realization and the critical stages of the WHO model of herbal drug development from TM, with a view to devising a framework that can be used to promote the production of quality herbal products, commencing from the stage of ethnobotanical survey, through the laboratory, to the clinic. Methodology: Both the WHO model of herbal drug development and the 7th clause of ISO 9001:2008...
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Posted by admin on Oct 1, 2012 in |
The versatility of Aluminium chemistry will ensure its burgeoning use in the future in all manner of applications. This very same chemistry will also ensure its increased biological availability in all biota including Man. We do not know enough about the biological chemistry of a chronic and sub-acute exposure to Aluminium to be able to predict its impact on human health. Although the hypothesis of a link between Aluminium and Alzheimer’s disease (AD) has been supported by several epidemiological studies, there is much controversy regarding these findings and their interpretation. There is no doubt that the drugs discovered for neurodegenerative disease are far from ideal, there are no more than acetylcholinesterase inhibitors, in fact alternative medicine could be moderate and protect nerves from neurotoxicity and AD. Curcumin is one of strong medicinal species that prove antioxidative stress effect against reactions cascade of neurofibrillary tangles. Our aim is to clarify the role of Curcumin with a fixative of absorption as a protective and therapeutic agent against neurodegenerative disorders and Alzheimer’s...
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Posted by admin on Oct 1, 2012 in |
Atherosclerosis is one of the risk factors for coronary artery disease. The present study highlights the antiatherosclerotic activity of Methanolic extract of polyherbal preparation in experimentally induced atherosclerotic rats. Atherosclerosis was developed in male Albino Wistar rats, which were randomly divided into five groups of six animals each; by feeding with high cholesterol diet for 21 days. Group 1 received normal diet. Group 2 received high cholesterol diet (HCD) which served as control. Group 5 served as standard, administered with Atorvastatin (10 mg/kg) along with HCD and Group 3 and Group 4 were administered with methanolic extract of polyherbal preparation (300 mg/kg and 600 mg/kg) along with HCD. Methanolic extract of polyherbal preparation reduced the raised serum level of total cholesterol, triglyceride , LDL ,VLDL and increased the serum HDL level as compared to the control group(High cholesterol group).There was increased HMG CoA/Mevalonate ratio in liver. There was also depletion of GSH content and increased level of SOD and MDA in liver. Methanolic extract of polyherbal preparation treated groups...
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