Posted by admin on Aug 1, 2012 in |
The aim of the present study was to evaluate antidiabetic and antioxidant potential of Aloe vera (AV) in alloxan induced diabetes in albino rabbits. Experimental Diabetes was induced in rabbits with alloxan(80mg/Kg body weight)and animals showing fasting blood glucose levels more than 250mg/dl were considered as diabetics and divided into four groups of six each (n=6). Group I: Normal control rabbits, Group II: Alloxan induced diabetic rabbits, Group III: Diabetic rabbits received AV gel extract (300 mg/Kg) in aqueous solution for 21 days, Group IV: diabetic rabbits given glibenclamide (600ug/kg) in aqueous solution. All the drugs were administered orally (using an intra gastric tube) in a single dose in the morning for 21 days. Blood samples were collected from the marginal vein of pinna of overnight fasted rabbits (Blood sugar, glycosylated hemoglobin (HbA1c), Malondialdehyde (MDA), reduced glutathione (GSH), total thiols (PSH) and Superoxide dismutase (SOD).Oral administration of AV showed potent antihyperglycemic and anti-lipidperoxidative effect in diabetic animals. Simultaneously, the levels of protective antioxidant enzymes (SOD, GSH and PSH) were...
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Posted by admin on Aug 1, 2012 in |
Carbon tetrachloride is a xenobiotic that produces hepatotoxicity. Aqueous extract Volvariella volvacea (500, 1000 mg/kg, p.o) showed significant hepatoprotective activity against carbontetrachloride induced hepatotoxicity in rats by normalizing the levels of serum AST, ALT, ALP, LDH and total bilirubin. The extract improved the activity of Catalase (CAT), Superoxide dismutase (SOD), and hepatic glutathione (GSH) content and depleted the lipid peroxidation levels in a dose dependent manner. Silymarin was used as the standard...
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Posted by admin on Aug 1, 2012 in |
The objective of this study is to induce experimental diabetes mellitus using Alloxan monohydrate in normal adult albino rats and study the anti‐diabetic activity of changes in body weight, consumption of food and water, volume of urine and levels of glucose between normal and diabetic rats. Diabetes mellitus (DM) is a common endocrine disorder. Hypoglycemic agents from natural and synthetic sources are available for treatment of diabetes. Indian medicinal plants have been found to be useful to successfully manage diabetes. The effect of methanolic and water extract of Solanum nigrum leaves was investigated in normal, glucose load conditions and Alloxan monohydrate ‐induced diabetic rats. Significant hypoglycemic activity was exhibited by the poly herbal...
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Posted by admin on Aug 1, 2012 in |
Anti-ulcer activity of the Solanum nigrum L. extracts was studied in rats by using pylorus ligated ulcer model. Rantidine was used as the standard drug for comparison. The animals were sacrificed after 19 hrs after the ligation. Stomach was dissected out and contents were drained into tubes and were centrifuged at 1000 rpm for 10min and volume was noted. The PH of gastric juice was recorded using a PH meter. The contents were subjected for analysis of free and total acidity. The numbers of ulcers per stomach was noted and severity of ulcers scored. Then the blood samples were collected and subjected to estimation of serum calcium and alkaline phosphatase level. The results revealed that 200 and 400mg/kg dosages of Solanum leaf extracts showed significantly comparable anti ulcer-activity as that of Rantidine, showing an anti-ulcer activity of the extracts. Thus Solanum nigrum leaves may reduce the acidity of the gastric juice and also prevent the mucosal damage and ulcer...
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Posted by admin on Aug 1, 2012 in |
The aim of present study was to determine whether pharmaceutical and pharmacological activity of aspirin would enhance in form of inclusion complex with β–cyclodextrin or not.Aspirin (Acetyl salicylic acid) a non steroidal anti-inflammatory drug, was formulated in to inclusion complex with β–cyclodextrin (β–CD) by solvent evaporation. The phase-solubility curve was AL type and Kst was found to be 127.8 M-1. FT-IR and microscopic examinatinos were revealed confirmation of inclusion formation. Solubility and permeability of aspirin was enhanced in presence of β–CD. Similarly the pharmacological activity i.e. analgesic and anti-inflammatory activity were also enhanced in presence of β –...
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