Posted by admin on Sep 1, 2012 in |
The present study describes a simple, accurate, precise and cost effective UV-Visible spectrophotometric method for the estimation of Riboflavin raw material. The Riboflavin is water soluble vitamin, so the solvent used throughout the experiment was 0.1N NaOH, the absorption maxima of drug was found at 445 nm. Beer’s law was obeyed in the range of 5ppm-30ppm. the developed method was successfully validated with respect to linearity, accuracy and precision. The method was validated and shown linearity in mentioned concentration. The correlation coefficient for Riboflavin was 0.999. The percentage relative standard deviation of inter-day precision range 0.66-1.04% and intra-day precision 1.05-1.39% both should be less than 2%. Hence proposed method was precise, accurate and cost effective, simple and rapid. This validated method can be applicable for quantitative determination of the titled drug with respect to assay from or for their solid dosage...
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Posted by admin on Sep 1, 2012 in |
Plant polyphenols have been studied largely because of the possibility that they might underlie the protective effects afforded by fruit and vegetable intake against cancer and other chronic diseases. The objective of the present study is to estimate the total polyphenolic content in aqueous and methanolic extract prepared from the bark of Acacia nilotica plant species. Acacia nilotica (L.) Willd. ex Del commonly known as babul, kikar or Indian gum Arabic tree, has been recognized worldwide as a multipurpose tree. Mostly it occurs as an isolated tree and rarely found in patches to a limited extent in forests and has been widely planted on farms throughout the plains of the Indian subcontinent. The bark, root, gum, leaves and flowers have found use for skin diseases, diarrhoea, dysentery, cough, diabetes, eczema, wound healing, burning sensation and as an astringent, demulcent, anti-asthmatic. For present work the bark of well identified A. nilotica (L) plant for the extraction of phytochemicals was done from the village Khargawali (Hoshangabad district). 20-20 grams of the...
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Posted by admin on Sep 1, 2012 in |
It is important to predict the serum thyroid hormones level in females during infertility to prevent its occurrence later on. In this study, we studied serum thyroid hormones and menstrual irregularities during infertility. A case control study was performed in 75 infertile patients with menstrual irregularities and 50 healthy matched women. Three biochemical parameters were measured in serum, hormones triiodothyronine (T3), tetra-iodothyronine (T4) and serum thyroid stimulating hormone (TSH) by TOSOH-AIA-360, immunoassay method. Out of 75 infertile women sixteen percent (16%) had menstrual irregularities with hypothyroidism. The mean serum thyroid level in 75 infertile women were 0.88±0.34 ng/ml, 7.69±2.87 μIu/dl and 5.43±6.88 μIu/ml, respectively. Serum T3, T4 and TSH level were statistically highly significant in infertile women. Serum thyroid stimulating hormone level was found at higher side in infertile women. High incidence of hypothyroidism was found in infertile women and it shows a positive correlation with menstrual...
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Posted by admin on Sep 1, 2012 in |
Losartan potassium is an angiotention receptor antagonist, used in the management of hypertension. The objectiveof the proposed research work is to prepare and evaluate the mouth dissolving/disintegrating tablets (MDTs) of losartan Potassium, which avoid the first-pass metabolism, improved the dissolution rate and enhance the bioavailability. Mouth dissolving tablets (MDTs) were prepared by direct compression method by using combination of superdisintegrant like Ac-Di-Sol and Polyplasdone-xl (1%,2%,3%&4%) and evaluated for physico-chemical evaluation parameter such as hardness, friability, weight variation, drug content uniformity, water absorption ratio, wetting time, in-vitro and in-vivo disintegration time, in-vitro dissolution studies. The control tablet (without superdisintegrant) was formulated and evaluated. The twelve formulations, B1to B8 were formulated and among these formulations, B8 was optimized. The hardness, friability, weight variation and drug content were found to be within pharmacopeias limits. The water absorption ratio, wetting time, in-vitro and in-vivo disintegration time of optimized formulation, B8 was found to be 86.1%, 8secs, 18secs and 25secs respectively. The formulation, B8 was considered to best formulation, which released up to 99.21%...
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Posted by admin on Sep 1, 2012 in |
Diospyros melanoxylon is a medium-sized tree or shrub which belongs to the family Ebenaceae. The whole plant is medicinally important and cures several diseases. Therefore, in this context the detailed pharmacognostic study of various parts like leaf, stem, petiole and root has been carried out with the aim to establish its Pharmacognostical standards. The parameters selected were microscopical studies, proximate analysis, fluorescence analysis and preliminary phytochemical screening. The microscopical studies of leaf,stem and root revealed the presence of branched trichomes,spiral xylem vessel. In physicochemical evaluation the ash values and extractive values were studied. Fluorescence analysis performed showed the wide range of fluorescence colors for the crude powder. The Diospyros melanoxylon powder was successively extracted with hexane, benzene, chloroform, ethylacetate, ethanol and water for the identification of the best solvent. Preliminary phytochemical screening was carried out for all the extracts and maximum chemical constituents were observed in the ethanolic...
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