Posted by admin on Aug 1, 2012 in |
The present study was designed to evaluate antidiabetic effects of ethanolic extract of Semecarpus anacardium (SA) stem barks in normal and alloxan induced diabetes rats. The antidiabetic effect of extract was evaluated investigated by measuring fasting blood glucose level and oral glucose tolerance test (OGTT) in normal and alloxan induced diabetes animal models. Here metformin (150 mg/kg) was used as reference drugs for comparison. The extract significantly (P<0.05) reduced blood sugar level in alloxan induced diabetic (hyperglycaemic) and glucose induced hyperglycemic (normo-hyperglycaemic) rats when given orally at doses of 200 mg/kg and 400 mg/kg body weight respectively. The glucose tolerance results showed the ethanolic extract significantly improved 55% and 68% at the dose of 200 mg/kg and 400 mg/kg body weight (b. wt.) whereas metformin showed 80% of that. The phytochemical screening of the plant S. anacardium stem bark showed the presence of steroids, triterpenoids, flavonoids, glycosides, saponins and tannins. However a glucose tolerance hypoglycemic test is comparable to diabetic control group and effect is a dose dependent. The...
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Posted by admin on Aug 1, 2012 in |
Corchorus olitorius L. belongs to the family Tiliaceae. It is a plant with diverse medicinal uses. Its leaves when used to cook, give rise to a ‘slimy, viscous’ soup, hence the interest in investigating its binding properties. Gum was extracted from its leaves using standard procedures. The extracted gum was then used to prepare paracetamol tablets using concentrations of 1%, 2%, 4% and 6% respectively. Its pharmaco-technical properties: friability, hardness, weight uniformity, disintegration time, percentage of fines, and angle of repose, were determined and compared with that of paracetamol produced from a commercial binder- Sodium carboxymethylcellulose (SCMC). The results obtained showed great promise and a comparative efficacy between the gum extract obtained from Corchorus olitorius L. and the...
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Posted by admin on Aug 1, 2012 in |
Diabetes is a debilitating metabolic disorder characterized by chronically elevated blood glucose level above the normal range and affects mostly all kind of populations epidemiologically. Objectives: In clinical situations, diabetic patients already on prescription of Rosiglitazone are prone to bacterial infection. To cure such infection Clarithromycin is prescribed particularly in Respiratory Tract Infections. Materials and Methods: Diabetes was induced experimentally in overnight fasted Rats by intraperitoneal injection of Nicotinamide, 15 min prior to intraperitoneal injection of Streptozotocin (60 mg/kg). Nicotinamide (160 mg/kg) was freshly prepared by dissolving in distilled water and Streptozotocin was dissolved in freshly prepared 0.1M Citrate buffer. Since Rosiglitazone and Clarithromycin have found to exert minimal to mild toxicity in animals on these doses, i.e. 80 mg/kg and 400 mg/kg respectively, both these drugs were administered for 14 days to the animals to study the toxicity in diabetic condition. Parameters included for the study includes body weight changes, oral glucose tolerance test, biochemistry, hematology, urine analysis and histopathology. Results: Clarithromycin aggravated hyperglycemia and reduced platelet count...
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Posted by admin on Aug 1, 2012 in |
Hypertensive disorders are important causes of premature delivery, IUGR and intra uterine fetal death. It accounts for 15% to 20% of maternal deaths in developing as well as developed nations. An association of serum uric acid with hypertensive disorders of pregnancy. The main objective of the present study was measuring and evaluating serum uric acid values in normal pregnant and preeclamptic and eclamptic cases to see the trend in the rise of serum uric acid in toxemic cases. Therefore we planned this study. The present study was conducted on Control(15 Normal non pregnant healthy women) and 140 cases they were further sub divided as, 60 Normal pregnant women in differenttrimesters, 60-Preeclampticcases, 20-Eclampticcases. Then Preeclampsia was divided into3groups (Mild preeclampsia – BP at least 140/90 mmHg. Moderate preeclampsia – BP more than 140/90 but <160/110mmHg. Severe preeclampsia – BP>160/110 mmHg but without convulsions). Estimation of serum uric acid was done at Department of Biochemistry, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand during June 2008 to Sept.2009. The cases were selected...
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Posted by admin on Aug 1, 2012 in |
6-[(5-pyridine-yl-1, 2, 3, 4-oxadiazole-2-yl)dithiol]-9H-purine (38) and 9H-purine-6yl-benzyldithiocarbamate (45) are synthesized as possible prodrugs for 6-mercaptopurine(6-MP). The generation of the compounds 38, 42, 45 and 48 were accomplished following multistep reaction procedures. The reaction and purity of the products were checked by TLC, the structure of the final compounds and their intermediates were confirmed by their melting points, infra red spectroscopy and whether differences elemental microanalysis. To determine exist among in sensitivity different tissue types toward treatment with 38 and 45. The cytotoxicity of the two compounds and their intermediates were confirmed by their melting points, infra red spectroscopy and elemental microanalysis. The cytotoxicity of two derivatives (38 and 45) was assessed in National Cancer Institute’s anticancer screening program, and the results were compared with the cytotoxicity of 6-MP obtained in the same screen. The results show that the compound 38 and 45 were more cytotoxic than 6-MP. Additionally the prodrugs are less effective against leukemia cell line than 6-MP. Both derivatives exhibited high growth-inhibitory activities in renal cell line....
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