Posted by admin on Jul 1, 2012 in |
Plants containing bioactive substances have increasingly become the object of research studies, opening alternative paths for therapeutic treatments or revealing substances that could later be explored and synthesized to produce pharmaceutical, cosmetic and agrochemical formulations. Alpinia purpurata have strong effect on H2O2 induced oxidative damages. The extract of Alpinia purpurata showed a higher antioxidant activity. The results suggest that the plants extract prevent oxidative damage in normal cells probably because of their antioxidant characteristics.“Phytochemicals or phytoconstituents” are becomingly known for their antioxidant...
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Posted by admin on Jul 1, 2012 in |
Vismia guianensis is a plant species of high occurrence in the Amazon and northeastern Brazil, which has been studied lately, because of its antimicrobial and anticancer properties.In order to make an herbal medicine, National Agency for Sanitary Surveillance of Brazil, recommends the production of a drug and plant extracts analysis report indicating: method, specifications and results obtained. The drug was characterized by particle size, amount of water and the total ash content; and plant extract through its density, pH and dry residue. The quantification of total anthraquinones and method validation was done by UV-VIS spectroscopy. The drug in this study produced a coarse powder whose determination of water is within the acceptable limits and the total ash content was 1.64%. The extractive solution showed a low pH, density of 0.89 mg/mL and 9.5% on yields from solids. HPLC found that the EtOAc fraction of the plant extract is consisted of phenolic compounds and anthraquinones. And the method of quantification of total anthraquinones, using emodin as external standard, was validated...
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Posted by admin on Jul 1, 2012 in |
ABSTRACT Study objective: To investigate the use of antihypertensive drugs in hypertensive patients and to identify whether such pattern of prescription is appropriate in accordance with international guidelines for management of hypertension. Methods: This was a prospective analysis. A prescription based survey among patients with established hypertension was conducted at the Medicine Out-Patient Department of University Teaching Hospital in South Delhi, India. Data were collected from patients’ medical records as well as patients’ interviews. Results: A total of 192 hypertensive patients fulfilled the criteria for inclusion in the study analysis. Combination therapy was used more commonly than monotherapy (54.6% vs 45.4). Among the monotherapy category, the various classes of drugs used were as follows: beta- blockers (28.8%), diuretics (24.1%), calcium channel blockers (21.8%), ACE inhibitors (18.4%), angiotensin II receptor blockers (5.7%) and α 1- blocker (1.1%). With respect to overall utilization pattern, diuretics (42.2%) were the most frequently prescribed class, beta- blockers (41.2%) ranked second followed by calcium channel blockers (39.1%), ACE inhibitors (26.0%), angiotensin II receptor blockers (23.4%)...
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Posted by admin on Jul 1, 2012 in |
The completion of genome sequences of pathogenic bacteria and the completion of human genome project has provided lot amount of data that can be utilized to design vaccines and drug targets. Recently adopting strategies for drug designing is based on comparative genomics approach, it gives a set of genes that are likely to be essential to the pathogen but absent in the host. By performing homology searches and structural modeling we can determine which of these proteins can function as the most effective surface epitope. This provides novel targets for functional inhibitors will result in discovery of novel therapeutic compounds active against bacteria. In this study, we used proteins that are potential target for Clostridium botulinum, this include, MATE efflux family protein, ComEC/Rec2 family protein, formate/nitrite transporter family protein. Physico-chemical characterization interprets properties such as pI, EC, AI, GRAVY and instability index and provides data about these proteins and their properties. Prediction of patterns, disulfide bridges and secondary structure were performed for functional characterization. Three dimensional structures for these...
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Posted by admin on Jul 1, 2012 in |
Growth disturbances are a major clinical feature of thalassemic patients. Regular blood transfusions and iron-chelation therapy greatly contribute to the quality and longevity of thalassemic patients. The main objective of present study was to compare the current growth of Thalassemia major patients, taking into accounts the iron overload, transfusion and iron chelation therapy, therefore we planned this study. The present study was conducted on 63 Thalassemic patients were enrolled in this study from June 2008 to October 2008. These subjects were categorised into two groups: 36 children (<10 years) and 27 adolescents (>10 years). Enrolled subjects were examined for various anthropometric parameters as height, weight and body mass index. Venous blood samples were obtained for estimating serum ferritin. Family history (carrier status of father, mother or siblings), age of diagnosis, age of first blood transfusion, frequency of blood transfusion and details of chelation therapy were recorded during the study Serum Ferritin level was very significantly elevated in the adolescents when compared to children because the number of transfusion increases...
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