Posted by admin on Aug 1, 2012 in |
The study was designed to scientifically evaluate the effect of alchoholic extract of Cyperus rotundus rhizomes, a traditional medicinal herb, on isoproterenol-induce myocardial necrosis in rats model. The albino wistar rats were divided into five different groups with six animal in each group. Group I serves as a control group, group II were given isoproterenol (85 mg/kg s.c) for 2 days while Group III was treated with metoprolol (10 mg/kg) for 28 days and isoproterenol on last 2 days. This group serves as standard group and its effect was used for comparison with that of test drug (Cyperus rotundus extract). Group IV and V were given Cyperus rotundus rhizome extract (300 mg/kg and 150 mg/kg respectively) for 28 days and isoproterenol on last 29th and 30th day. The level of enzymes transaminases (aspartate transaminase and alanine transaminase), Lactate dehydrogenase (LDH), Cretinine kinase (CK) were estimated in serum and the extent of necrosis was studied by grading. Isoproterenol significantly increased the activities of CK, LDH and the transaminases in serum....
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Posted by admin on Aug 1, 2012 in |
Background and Purpose: Integrated teaching is new in pharmacology. In the present study, evaluation and comparison of integrated teaching, conventional theory teaching and tutorial has been done. Material and methods: Ten pre and post tests were conducted each for integrated teaching, theory class and tutorial for 126 students. Student’s attitude towards these teaching methods and bedside clinical teaching were analysed. Results: There was significant improvement in post test scores when compared with pre test scores in all three types of teachings. When post and pre test’s differences were compared, conventional theory teaching was significantly effective than integrated teaching which in turn was significantly effective than tutorial. Student’s attitude tests revealed merits and demerits of theory class, tutorial, integrated teaching and bedside clinical teaching. Conclusion: Integrated teaching will promote active learning. Conventional theory and tutorial classes are popular due to their easiness in acquiring and consolidation of the knowledge respectively. These findings will help in further educational...
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Posted by admin on Aug 1, 2012 in |
The aim of the present study was to evaluate antidiabetic and antioxidant potential of Aloe vera (AV) in alloxan induced diabetes in albino rabbits. Experimental Diabetes was induced in rabbits with alloxan(80mg/Kg body weight)and animals showing fasting blood glucose levels more than 250mg/dl were considered as diabetics and divided into four groups of six each (n=6). Group I: Normal control rabbits, Group II: Alloxan induced diabetic rabbits, Group III: Diabetic rabbits received AV gel extract (300 mg/Kg) in aqueous solution for 21 days, Group IV: diabetic rabbits given glibenclamide (600ug/kg) in aqueous solution. All the drugs were administered orally (using an intra gastric tube) in a single dose in the morning for 21 days. Blood samples were collected from the marginal vein of pinna of overnight fasted rabbits (Blood sugar, glycosylated hemoglobin (HbA1c), Malondialdehyde (MDA), reduced glutathione (GSH), total thiols (PSH) and Superoxide dismutase (SOD).Oral administration of AV showed potent antihyperglycemic and anti-lipidperoxidative effect in diabetic animals. Simultaneously, the levels of protective antioxidant enzymes (SOD, GSH and PSH) were...
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Posted by admin on Aug 1, 2012 in |
Carbon tetrachloride is a xenobiotic that produces hepatotoxicity. Aqueous extract Volvariella volvacea (500, 1000 mg/kg, p.o) showed significant hepatoprotective activity against carbontetrachloride induced hepatotoxicity in rats by normalizing the levels of serum AST, ALT, ALP, LDH and total bilirubin. The extract improved the activity of Catalase (CAT), Superoxide dismutase (SOD), and hepatic glutathione (GSH) content and depleted the lipid peroxidation levels in a dose dependent manner. Silymarin was used as the standard...
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Posted by admin on Aug 1, 2012 in |
The objective of this study is to induce experimental diabetes mellitus using Alloxan monohydrate in normal adult albino rats and study the anti‐diabetic activity of changes in body weight, consumption of food and water, volume of urine and levels of glucose between normal and diabetic rats. Diabetes mellitus (DM) is a common endocrine disorder. Hypoglycemic agents from natural and synthetic sources are available for treatment of diabetes. Indian medicinal plants have been found to be useful to successfully manage diabetes. The effect of methanolic and water extract of Solanum nigrum leaves was investigated in normal, glucose load conditions and Alloxan monohydrate ‐induced diabetic rats. Significant hypoglycemic activity was exhibited by the poly herbal...
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