Posted by admin on Aug 1, 2012 in |
QSAR study of lipid peroxidation (LPO) inhibitory activity of 18 flavonoids belonging to four classes namely flavones, isoflavones, flavonols and flavanones has been made with the help of PM3 calculations and geometry optimizations using CAChe software. Quantum-chemical descriptors were calculated by the same software using MOPAC 2002 engine. Two quantum-chemical descriptors, molar volume (M.V.) and dipole moment (μ) and two new indicator descriptors of electron densities on carbon and oxygen atoms are used for QSAR analysis. The results are highly encouraging as average values of correlation and cross validation coefficient are 0.794 and 0.754. Four QSAR models have high predictive power while one model has average predictability. These models can successfully predict the antioxidant activity of any newly discovered flavonoid which can later be tested in laboratory....
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Posted by admin on Aug 1, 2012 in |
The method for the simultaneous estimation of Cinnarizine and Domperidone maleate from tablet dosage form has been developed, based on simultaneous equation method at two selected wavelength 254nm and 284nm respectively, and also absorbance ratio method at two selected wavelengths 274.0nm (Iso-absorptive point) and 254.0nm (λmax of cinnarizine). The linearity was obtained in the concentration range of 5-20μg/ml and 5-20μg/ml for cinnarizine and Domperidone maleate respectively. These methods are simple, accurate and results of analysis have been validated statistically and by recovery...
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Posted by admin on Aug 1, 2012 in |
The aim of present investigation is to study the effect of oral administration of drug acetylsalicylic acid (ASA, aspirin) on female albino rat, Rattus norvegicus. The female rats (n=24) were allocated into 2 groups as control (n=12) and treated (n=12). The treated rats were given oral dose of aspirin 100 mg/ kg body weight for 15 days (n=6) and 30 days (n=6). Tissues enzymological estimations such as ACP (Acid Phosphatase) and ALP (Alkaline Phosphatase) along with histopathological studies of reproductive organs (ovary and uterus) were done. The present investigation indicated that, aspirin significantly increased ACP and ALP content in reproductive tissues and also caused significant histopathological variations in reproductive organs such as ovary and uterus by modulating certain enzyme metabolism in female albino...
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Posted by admin on Aug 1, 2012 in |
Celosia argentea is a medicinal herb belonging to the family Amaranthaceae has been used traditionally in Ayurveda for the treatment of diarrhoea and dysentery. Extensive studies have been carried out to substantiate its various claimed pharmacologic activities. Present communication records the Pharmacognostic evaluation like Macroscopic and Microscopic characters and Physiochemical evaluation like Foreign matter, Moisture content, pH, Ash value, Extractive value, Crude Fibre content and Foaming Index. Fluorescence analysis and Phyto-chemical investigations on this plant reveal the presence of Carbohydrates, Amino acids, Glycosides, Saponins, Alkaloids, Flavonoids, Phenolic compound and Tannins in different extracts. Pharmacognostic and Qualitative chemical evaluation of whole plant should be helpful for identification and preparation of monograph of the...
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Posted by admin on Aug 1, 2012 in |
Nanoparticles, generally considered as particle with a size of upto 100nm, exhibit completely new or improved properties as compared to the larger particles of the bulk material that they are composed of based on specific characteristics such as size, distribution and morphology. In this study ZnO nanoparticle was synthesized by a simple and easy chemical method from ZnCl2. The synthesized nanoparticle was characterized by SEM and EDAX. Antibacterial activity of ZnO was observed against E. coli, Enterobacter sp., Bacillus subtilis, Bacillus cereus, Klebsiella pneumoniae, Staphylococcus aureus, Salmonella typhi, Vibrio cholerae by disc diffusion method. Preliminary Cytotoxicity of nanoparticle was studied by MTT assay against vero cell line. ZnO nanoparticle had shown antibacterial activity against all the tested bacteria and maximum activity was observed against salmonella typhi. ZnO nanoparticles has shown less cytotoxicity effect on vero cell than...
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