Posted by admin on May 1, 2012 in |
Garlic a perennial erect plant is known to have sulphur-containing compounds that act on the hypothalamus increasing the sensitivity of the hypothalamus to leptin which alters the set point at which satiety is reached causing an organism to eat less. Nine mice (six of which were obese) were used in this study and grouped into three. Groups A and B were made of 3 obese mice each whereas group C consisted of 3 non-obese mice. For group A and group C mice, 20 ml aqueous garlic extract was added to their feed daily whereas no garlic was added to the feed of group B mice. The study was carried out over a period of 44 days. The weight and blood glucose was measured weekly and the average for each group was computed. Results indicated that Group A mice recorded a reduction in mean body weight by 46.5% (p<0.05). Group B mice had significant increase in mean body weight by 46.2% (p<0.05). The blood glucose level dropped significantly by 18.5%...
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Posted by admin on May 1, 2012 in |
Bergenin is reported to occur in Viburnum nervosum (Capprifoliaceae). This is the first report of its occurrence in genus Viburnum. Derivative of Bergenin viz Bergenin diethyl ether, its penta acetate and diethyl ether triacetate have been prepared. Their method of preparation and characterization by spectroscopy is reported for the first...
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Posted by admin on May 1, 2012 in |
Patients with chronic dental infection are usually treated with antibiotics. However, the value of antibiotics was decreasing because increased resistance in bacteria. The objective of this study is to evaluate the efficacy of herbal crude extract of Mentha arvensis in human Cariogenic pathogens. In this study we obtained crud extract of Mentha arvensis in different solvent 50% and 10% methanol, ethyl acetate, chloroform and was tested against human Cariogenic pathogens Streptococcus mutans, Streptococcus sangunis, Staphylococcus aurues, Lactobacillus casei were isolated from patients having dental disease. The crude extracts activity were studied by disc diffusion and both dilution methods in different concentration. Studies were also undertaken to assess the phytochemical composition of the Mentha arvensis extract. 50% methanolic extract at 2.5mg/ml and 5mg/ml concentration shows slightly bigher zone of inhibition (ranging from 26 to 30 mm and 28 to 32 mm), and 10% methanolic 2.5mg/ml and 5mg/ml extract shows slightly small zone (ranging from 20 to 24 mm and 22 to 27 mm) and comparison with ethyl acetate and chloroform...
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Posted by admin on May 1, 2012 in |
Four simple, rapid, precise, economical and accurate spectrophotometric methods have been developed for simultaneous analysis of Metoprolol succinate and Telmisartan in their combined dosage form. Method 1, First derivative simultaneous equation method (Vierodt’s method). It employs formation and solving of simultaneous equation using two wavelengths 230.2 nm (λmax of Metoprolol succinate) and 237 nm (λmax of Telmisartan) in first derivative spectra. Method 2, First derivative Q-Absorbance equation method. It involves, formation of Q-absorbance equation at 231.8 nm (isoabsorptive point) and 237 nm (λmax of Telmisartan) in first derivative spectra. Method 3, Absorbance correction method, involves measurement of absorbance at 296.6 nm for estimation of TEL and measurement of corrected absorbance at 223 nm for estimation of MET. Method 4, Combination of First derivative dual wavelength ,which uses the difference in absorbance at 282.4 nm and 284.6 nm for estimation of MET and zero crossing first derivative spectrophotometry involves measurement of amplitudes at 330 nm for estimation of TEL in first derivative spectra. Developed methods were validated according to ICH...
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Posted by admin on May 1, 2012 in |
Background/Aim: Endosulfan is a pesticide of organochlorine group uses by 55 % of farmers in Bihar. Present study aims to illustrate effect of Endosulfan on biochemical, hormonal and sub cellular anomalies of spermatozoa of mice and their restoration through root extract of Withania somnifera. Materials and Methods: Experimental mice were administered with endosulfan for eight weeks followed by eight weeks administration of Withania somnifera. Results: Endosulfan administered group show degenerated mitochondria and plasmamembrane. Degenerated microtubule were also observed with rudimentary central hub and dynein arm. While eight weeks Withania somnifera 1000 mg/kg/b.w/day administered group show greater degree of sub cellular restoration on mitochondria and nuclear membrane. Microtubules were almost normal in structure. Lipid peroxidation level were also restored toward normal after ashwagandha administration. Conclusion: These combined effect finally leading to restoration in structure of spermatozoa in mice. This is very effective in restoring male fertility by combating endosulfan...
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