Posted by admin on Jun 1, 2012 in |
Background: Hypertension is an immensely pervaded problem in today’s population and is a unanimous major risk factor for heart diseases. Various natural herbs have been found to control the hypertension exquisitely without causing any significant adverse effect. Eclipta alba (EA) and Boerhaavia diffusa (BD) are two herbaceous plants. EA is used to treat hepatic-dysfunction, hair diseases and anemia since ancient time. Similarly, BD is a great treatment-option for renal and urinary disorders. They have also been found quite effective in the safe treatment of hypertension. But studies in this respect are very scanty and confirmatory role of these herbs in hypertension is yet to be established. In the present study, effects of EA and BD on normal blood pressure (NBP) and hypertension were studied. Their antihypertensive activities were also compared with those of Amlodipine (Amlo). Methods: Adult Wistar rats of both sexes, weighing 140-150 g were randomized equally to make 9 groups (6 rats/ group). First 6 groups were given high fat diet for 49 days to produce hypertension....
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Posted by admin on Jun 1, 2012 in |
This present investigation was an attempt to an ethno botanical survey which was carried out by the local practitioners of Coimbatore district in Tamil Nadu. During the survey 48 medicinal plant leaves are identified which were used as medicine for several diseases either in single or in combination with some other ingredients. In the first phase the Botanical Name, Family, Local Name and uses of leaves have been discussed and noted....
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Posted by admin on Jun 1, 2012 in |
Two triterpine acids like 2α, 19α- dihydroxy – 3-oxo-12- ursen- 28-oic acid (1), 2α, 16α, 19α- trihydroxy – 3-oxo-12- ursen- 28-oic acid (2) were isolated from the n-hexane soluble fractions of a methanol extract of the root of Albizzia lebbeck Benth. The structures of the isolated compounds were elucidated as by extensive spectroscopic studies, including high field NMR analyses. This is the first report of isolation of compounds 1- 2 from this...
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Posted by admin on Jun 1, 2012 in |
The aim of the present study is to formulate and evaluate controlled release formulation of lornoxicam based on osmotic technology. Lornoxicam, a potent non-steroidal anti-inflammatory drug (NSAID) with shorter half life, makes the development of sustained release (SR) dosage forms extremely advantageous. However, due to its weak acidic nature, its release from SR delivery system is limited to the lower GIT which consequently leads to a delayed onset of its analgesic action. Basic pH modifier tromethamine and wicking agent SLS were incorporated into the core tablet to create basic environmental pH inside the tablets, which provide complete drug release that starts in the stomach to rapidly alleviate the painful symptoms and continue in the intestine to maintain protracted analgesic effect. The effect of different formulation variables namely level of osmogen (mannitol) in the core tablet and level of pore former (sorbitol) in the coating membrane on in-vitro release was studied. Lornoxicam release from controlled porosity osmotic pump was directly proportional to the pore former (sorbitol) and level of osmogen...
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Posted by admin on Jun 1, 2012 in |
Daily oral administration of the total alcoholic extract and its ethyl acetate fraction of the bark of Cassia fistula in alloxan induced diabetic rats exhibited significant reduction in blood glucose levels and also found effective in restoring the blood lipids to normal levels. The activity was found comparable with standard drug glibenclamide. The ethyl acetate fraction showed more significant antidiabetic effect. The chromatographic isolation of ethyl acetate fraction summarizes the presence of flavonoidal...
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