Posted by admin on Apr 1, 2012 in |
Trikatu churna is one of the traditional poly herbal preparation, formed by mixing equal quantities of three important spicy materials such as Piper longum L. (Piperaceae), Piper nigrum L. (Piperaceae)and Zingiber officinale Roscoe (Zingiberaceae). Trikatu is also known as “ Three Bitters”. The trikatu preparation was reported to contain alkaloids, phenols, tannins, flavanoids, steroids, lignin & saponins. The objective of study is to evaluate the antimicrobial activity of trikatu churna & its individual ingredients with their preliminary phytochemical study. The aqueous extracts of trikatu churna & its each ingredient were tested for antimicrobial activity against certain bacterial strains of Escherichia coli, Staphylococcus aureus by in vitro agar well diffusion method and the results are recorded as the zone of inhibition. Trikatu churna was found to possess higher extent of phytoconstituents with promising antimicrobial...
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Posted by admin on Apr 1, 2012 in |
Background: Evidences notify that most of higher learning students rush to range of maladaptive high-risk activities like, substance and sexual abuse which predispose to HIV. More often this is unrecognized and not well researched. Objective: To determine magnitude of substance use and risky sexual behavior for HIV transmission among students in Hosanna Health Science College from December 1, 2010 to December 30, 2010. Methods and Materials: Cross sectional study undertaken among statistically determined (n) =428 and randomly selected Students from all departments and years of study in Hossana Health Science College. Piloted and self-administered questionnaire were used to collect data. Summary measures like mean, chi-square and regression were utilized to quantify magnitude and identify independently associated factors. Results: Majority 267 (63.1%) of study participants were female, and 379 (89.5%) in age group (17-24). From 423 participants, 330(78.0%) were, sexually experienced. Khat (27.7%) and Alcohol (21.7%) were the commonly used substances and having multiple sexual partners (47.6%), inconsistent condom use (20.0%) were common sexual risk behaviors for HIV transmission. Female...
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Posted by admin on Apr 1, 2012 in |
Clitoria ternatea L. (Family: Fabaceae) is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antioxidant and antiasthmatic activity of ethanol extract of Clitoria ternatea roots. The present investigation was undertaken to evaluate the histamine-induced bronchospasm of alcoholic extract of Clitorea ternatea Linn. roots in experimental animals. Bronchodilator activity of aqueous extract of C. ternatea studied on the histamine aerosol induced bronchospasm in wister rats. Treatment with alcoholic extract of clitorea ternatea (400 mg/kg, p.o) showed significant protection against histamine aerosol induced broncho-spasm in wister rats. The results of the histamine- induced bronchospasm paradigms demonstrate bronchospasmolytic activity of ethanolic extract of clitorea ternatea (400 mg/kg, p.o.). Clitorea ternarea shows 47.45 % protection against histamine induced bronchoconstriction in rats. These results suggest that aqueous extract of C. tenatea has not only bronchodilating activity but also decreases bronchial hyperreactivity by decreasing the infiltration of inflammatory cells in the airway and inhibition of release of histamine like mediators from the mast cell...
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Posted by admin on Apr 1, 2012 in |
Alstonia scholaris (L.) R. Br. is a plant of family Apocynaceae and has a great medicinal importance. It is widely used by tribal people to treat various diseases and ailments. The present communication deals with the organoleptic and preliminary physico-phytochemical studies of the stem bark of the plant. The organoleptic study was done according to the W.H.O. guidelines for medicinal plants. The physicochemical parameters viz. loss on drying, ash values and extractive values were calculated. Soxhlet extraction of the powdered plant material was done with 80% ethanol and then partitioned with petroleum ether, ethyl acetate and n-butanol subsequently. The percentage yields of different solvent fractions were calculated and then they were subjected to preliminary phytochemical screening which indicated the presence of alkaloids, carbohydrates, tannins, terpenoids, saponins, flavonoids, steroids and fixed oils and...
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Posted by admin on Apr 1, 2012 in |
The objective of this study was to design and evaluate oral sustained drug delivery system for Metoprolol succinate using pH sensitive polymer HPMC and sodium alginate and to evaluate its efficacy in reducing the hypertension. The drug filler blend was mixed with various concentrations of hydrophilic polymers such as HPMC, sodium alginate and combination of both the matrixing agents. The tablets were prepared by wet granulation method. Matrix tablets were evaluated for weight variation, content uniformity, friability, hardness, thickness, swelling index, and in vitro dissolution. The assays of different formulations were determined and the drug content was found between 85-115%. The weight variation was observed to be within the prescribed limits for each formulation. In-Vitro drug release studies carried out with different formulation tablets in 0.1N HCl for 2hrs, pH 6.8 phosphate buffer for 12hrs. Up to 2 hr study the formulation shows low release in gastric medium (0.1N HCl). From the 2 hr up to 12 hr study percentage of drug release was increased in intestinal fluid (pH...
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