Posted by admin on May 1, 2012 in |
The present study was designed to evaluate the heavy metal absorbing potential of bacteria isolated from industry effluent sites of river Nagavali, Srikakulam Andhra Pradesh. From the effluent waste water three bacteria were isolated and confirmed as Staphylococcus aureus and Staphylococcus epidermidis and Staphylococcus saprophyticus after performing various biochemical tests. The heavy metal tolerant efficiency was determined by analyzing the growth of the bacteria in presence of heavy metal (Cu, Hg, Co and Zn) solution and their optimum tolerance was determined by measuring the optical density at 600nm after 24hr and 48hr of incubation. Staphylococcus aureus, Staphylococcus epidermidis and Staphylococcus saprophyticus were found to grow in heavy metal...
Read More
Posted by admin on May 1, 2012 in |
The present investigation was carried out to study the antidiabetic effect of the methanolic extract of bark of Bauhinia purpurea in Streptozotocin induced diabetic model. The antidiabetic activitywas evaluated in normal & Streptozotocin induced diabetic rats. Decreased blood glucose level of the test animals showed that the extract exhibited significant antidiabetic activity when compared to diabetic control group. The results also indicated dose dependent effect. The antidiabetic activity produced by the extract might be due to the increased uptake of glucose at the tissue level or due to an increase in pancreatic beta cell function or due to inhibition of intestinal absorption of...
Read More
Posted by admin on May 1, 2012 in |
In the present investigation, an attempt has been made to prepare sustained release microspheres of Glibenclamide by using Eudragit RS 100 as rate retardant polymer. Microspheres were successfully prepared by non-aqueous emulsion solvent evaporation method. Magnesium stearate was used as hydrophobic dispersant and droplets stabilizer. The yields were varies from 90-97% and encapsulation efficacy is up to 94% which encourage the investigation. The desired sizes of microspheres were obtained when the stirring was carried out at 600 rpm. The in-vitro dissolution profile of optimized formulation batch i.e., F5 is resulted up 11.5 hours. The various parameters of model equation of microspheres containing Glibenclamide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi Model and Korsmeyer-Peppas Model. To establish the release kinetic, Korsmeyer-Peppas Model shows the prominent release characteristics and the release pattern is non-fickian diffusion controlled. The SEM photograph of microspheres confirmed good spheres and smooth surface of the microspheres. The IR and DSC studies used to of...
Read More
Posted by admin on May 1, 2012 in |
Mikania scandens is a rapidly growing herbaceous to semi-woody, perennial vine. It grows quickly over other plants such as young trees, smothering them; it can climb trees up to 25 m tall. Although not as serious a weed as M. chordate, in Southeast Asia it has become a hard to eradicate weed of tea, rubber, and other plantation crops. It also reduces the carrying capacity of pasture. The achenes are spread by wind, water and animals. The plant also reproduces by old rootstocks, runners and suckers. It is still under investigation. Although it has some analgesic and anti-inflammatory properties, but these uses are not widely accepted till now. Folkloric uses include utilisation of the herb as an anticoagulant or other medicinal purpose. The aim of the undertaken work is to identify and isolate the chemical constituents of the plant Mikania scandens and to evaluate its reported analgesic...
Read More
Posted by admin on May 1, 2012 in |
The present study was aimed to evaluate the antihyperlipidemic effect of aqueous extract of stem of Tinospora cordifolia in streptozotocin induced diabetic and diet induced hyperlipidemic rats. Diabetes mellitus was induced in male albino Wistar rats by intraperitoneal injection of streptozotocin (45 mg/kg b.w.). Hyperlipidemia was induced in diabetic rats by feeding 0.5% cholesterol and 0.1% cholic acid on diet basis in arachis oil (10 ml/kg b.wt) orally throughout the experimental period and simultaneously, the treatment groups received T. cordifolia (100 and 200 mg/kg b.w.) orally for 14 days. Glibenclamide (600 µg/kg b.w) was used as a standard antidiabetic drug and atorvastatin (1.2 mg/kg b.w.) was used as a standard antihyperlipidemic drug. Serum glucose levels were determined at weekly intervals and serum cholesterol, triglycerides, HDL-C, creatine kinase and free fatty acids were analyzed at the end of the experiment. Aqueous extract of T. cordifolia at 200 mg/kg b.w. dose decreased serum glucose, cholesterol, triglycerides, creatine kinase, and free fatty acids to normal level when compared to that of standard...
Read More
