Posted by admin on Apr 1, 2012 in |
This study aimed to discover the antibacterial effect of Acmella oleraceae against dental caries bacteria and aware the populace about the importance of using phytomedicines. According to this study, the antibacterial effects of Acmella oleraceae was checked against the dental caries bacteria using well diffusion method. Phytochemical screening of Acmella oleracea checked with chloroform, ethanol, methanol and water and acetone extracts. Screening tests revealed that this plant is a big source of phytochemical compounds. The phytochemical analysis of Acmella oleracea is conducted using Thin Layer Chromatography (TLC).Acetone solvent system of Acmella oleracea showed two spots with highest Rf value 0.922. Three compounds were obtained in the chloroform solvent system with highest Rf value of...
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Posted by admin on Apr 1, 2012 in |
This article is giving emphasis on the decisive role of particle size of highly hydrophobic lubricant i.e. Magnesium Stearate, its concentration and lubrication time to establish the desired quality attributes of formulation containing highly soluble model drug Metformin Hydrochloride. Magnesium Stearate from two sources with different Particle size distribution (PSD) range was selected. It was observed that the Magnesium Stearate with a designed PSD is controlling the drug release profile of Metformin hydrochloride Tablets, which can replace the use of excess quantity of Magnesium Stearate or addition of a rate controlling polymer like hydroxy propyl methyl cellulose in the formulation...
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Posted by admin on Apr 1, 2012 in |
The aim of this research was to formulate a matrix-type transdermal therapeutic system containing drug ciprofloxacin with different ratios of hydrophobic (ethyl cellulose) polymer by solvent evaporation technique, using 15% w/w of dibutyl phthalate to the polymer weight, incorporated as plasticizer. Different concentrations of isopropyl myristate were used to enhance the transdermal permeation of Ciprofloxacin. Formulated transdermal films were physically evaluated with regard to thickness, weight variation and drug content. All prepared formulations showed good physical stability. In-vitro permeation studies of formulations were performed by using Franz diffusion cells. Formulation T3 showed best in-vitro skin permeation through goat skin as compared to all other formulations. The release profile of the optimized formulation T3 indicated that the permeation of the drug from the patches was governed by a diffusion mechanism. Formulation T3 showed highest flux among all other formulations. These results indicate that the formulation containing highest amount of isopropyl myristate gives better penetration of ciprofloxacin through goat...
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Posted by admin on Apr 1, 2012 in |
An ethnomedicinal plant, Hugonia mystax L., was examined for preliminary phytochemical screening and antimicrobial activity. Preliminary phytochemical screening showed the presence of various classes of secondary metabolites such as flavonoids, phenols, saponins, steroids, tannins and terpenoids. Antimicrobial activity of petroleum ether, chloroform, ethanolic and aqueous fruits extracts showed significant activity against the human pathogens such as Streptococcus pneumoniae causing brain abscesses, pneumonia and septic arthritis; Proteus vulgaris, Pseudomonas aeruginosa causing urinary tract infections and septicaemia; Salmonella typhi causing typhoid fever, Vibrio species causing diarrheal infections and the fungus Candida albicans causes urinary tract infections. The antimicrobial activity of the petroleum ether, chloroform, ethanolic and aqueous fruits extracts showed concentration-dependent activity against all the tested bacteria at various concentrations. Thus, the present findings revealed the medicinal potential of H. mystax to develop a drug against various human...
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Posted by admin on Apr 1, 2012 in |
Present studies on the synthesis and evaluation of anticonvulsant activity of some 6- Substituted- 6H- Pyrrolo [3, 4-d] Pyridazine derivatives. In the preliminary screening for anticonvulsant activity in albino rats, all the synthesized compounds were found to be active, even more than standard at dose 50mg/kg body...
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