Posted by admin on Apr 1, 2012 in |
Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15M CR and Methocel K100M LVCR, starch 1500, talc and magnesium stearate considering technical feasibility and performed a comparative study with the release pattern. The tablets showed sustained release curves at pH 6.8 phosphate buffer for up to 12 h. The granules showed satisfactory flow properties, compressibility index and drug content etc. All the tablets complied with pharmacopoeial specifications. The results of dissolution studies indicated that the formulations F-6 and F-8 could extend the drug release up to 12 h. The data obtained from the dissolution profiles were compared in the light of different kinetics models and the regression coefficients were also compared. Kinetic modeling of in vitro dissolution profiles revealed the drug release mechanism ranges from diffusion controlled or Fickian transport to anomalous type or non-Fickian transport, which was only dependent on the type and amount of polymer used. The drug release followed...
Read More
Posted by admin on Apr 1, 2012 in |
Eleutherine plicata Herb., Iridaceae, is an herbaceous Iridaceae, vernacular marupazinho, largely used as tea, in the Amazonian popular phytotherapy, to treat diarrhoea alleged to amoeba infestation. To investigate the form of use of this medicinal plant andits alleged activity, and to perform a phytochemical analysis and an anti-amoebaean assay. Bulbs of the plant were dried, grinded and extracted in boiling water. After concentration the extract (AEEp) was analysed by LC-DAD and tested against trophozoitic forms of three strain of Entamoeba histolytica/Entamoeba dispar. A significant peak in the LC-DAD chromatogram of AEEp can be observed and attributed to isoeleutherine, a naphtoquinone also an antiamoebian activity was detected for this extract. Isoeleutherine would be one of the active substances responsible for the anti-amoebaean activity of Eleutherineplicata Herb., since naphtoquinone show anti-protozoal activity and the substance shows pro-oxidative properties. Noteworthy is the fact that the decoction shows 3.5mg dry residue/mL, 40% higher than the concentration of the extract used in the bioassay (2.5mg/mL). The detected antiamoebian activity for AEEp aligns to the...
Read More
Posted by admin on Apr 1, 2012 in |
The objective of the study is to evaluate Olibanum resin, a natural resin polymer as matrix polymer for controlled release tablets and to design matrix tablets of diclofenac for controlled release. Matrix tablets of diclofenac were formulated employing Olibanum resin in different proportions of drug and polymer and the tablets were evaluated for drug release kinetics and mechanism. Two diluents namely lactose (water soluble) and DCP (water insoluble) were included in the formulations to assess their influence on drug release characteristics of olibanum resin matrix tablets. Matrix tablets were found to be non- disintegrating in water, acidic (pH 1.2) and alkaline (pH 7.4) fluids and were considered suitable for oral controlled release. Diclofenac release from the matrix tablets formulated was slow and spread over 24 h and depended on the concentration (%) of olibanum resin in the matrix tablets and nature/type of diluent. As the concentration of olibanum resin in the matrix tablets was increased, drug release was decreased. Release was relatively faster with water soluble diluent lactose when...
Read More
Posted by admin on Apr 1, 2012 in |
Trikatu churna is one of the traditional poly herbal preparation, formed by mixing equal quantities of three important spicy materials such as Piper longum L. (Piperaceae), Piper nigrum L. (Piperaceae)and Zingiber officinale Roscoe (Zingiberaceae). Trikatu is also known as “ Three Bitters”. The trikatu preparation was reported to contain alkaloids, phenols, tannins, flavanoids, steroids, lignin & saponins. The objective of study is to evaluate the antimicrobial activity of trikatu churna & its individual ingredients with their preliminary phytochemical study. The aqueous extracts of trikatu churna & its each ingredient were tested for antimicrobial activity against certain bacterial strains of Escherichia coli, Staphylococcus aureus by in vitro agar well diffusion method and the results are recorded as the zone of inhibition. Trikatu churna was found to possess higher extent of phytoconstituents with promising antimicrobial...
Read More
Posted by admin on Apr 1, 2012 in |
Background: Evidences notify that most of higher learning students rush to range of maladaptive high-risk activities like, substance and sexual abuse which predispose to HIV. More often this is unrecognized and not well researched. Objective: To determine magnitude of substance use and risky sexual behavior for HIV transmission among students in Hosanna Health Science College from December 1, 2010 to December 30, 2010. Methods and Materials: Cross sectional study undertaken among statistically determined (n) =428 and randomly selected Students from all departments and years of study in Hossana Health Science College. Piloted and self-administered questionnaire were used to collect data. Summary measures like mean, chi-square and regression were utilized to quantify magnitude and identify independently associated factors. Results: Majority 267 (63.1%) of study participants were female, and 379 (89.5%) in age group (17-24). From 423 participants, 330(78.0%) were, sexually experienced. Khat (27.7%) and Alcohol (21.7%) were the commonly used substances and having multiple sexual partners (47.6%), inconsistent condom use (20.0%) were common sexual risk behaviors for HIV transmission. Female...
Read More
