Posted by admin on Feb 1, 2012 in |
The safety and efficacy of a pharmaceutical dosage form can be guaranteed when its quality is reliable. The efficacy of pharmaceutical dosage forms generally depends on their formulation properties, and manufacturing methods, hence it is likely that the quality of dosage form may vary. The aim was to evaluate the quality of paracetamol tablet marketed in Somali region of Ethiopia. The study was exclusively experimental that used BP, USP and other standard books to check the in vitro quality of Paracetamol tablet using different analytical techniques and procedure. Test for weight variation, friability, disintegration time, identification test and assay were conducted. All of the brands under the study were within the specification for weight variation test. But from the contraband brands, two for friability, one for disintegration and all for percentage content paracetamol failed to satisfy the requirement though all of the products contain the wright active ingredients. The research has showed that the quality of contraband tablets were below the standard in contrast to the legal paracetamol tablet...
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Posted by admin on Feb 1, 2012 in |
Trihexyphenidyle is a lipophilic antiparkinsonian drug with short half life. Practically slightly soluble in water makes formulation and delivery difficult. By formulating the same in the microcapsule by using biodegradable polymer Eudrajit L 100 and S 100, the half life and solubility can be altered and hence drug release pattern. Trihexyphenidyle microcapsules were prepared by solvent evaporation method by using different drug-polymer ratio (1:2, 1:3, 1:4, 1:5). Prepared microcapsules were evaluated for the particle size, percentage yield, incorporation efficiency, flow property and in vitro drug release at pH 6.8 for 12 hours. From the result we can conclude that as the concentration of polymer increases, it affects the particle size, percentage yield and drug release of micro capsules. The formulation F2 shows the excellent flow properties, particle size, percentage yield (91.24%), incorporation efficiency (94.59%) and percentage drug release (95.88%) for a period of 12 hrs. Results of the present study indicate that Trihexyphenidyle microcapsules can be successfully designed to develop sustained drug delivery, that reduces the dosing frequency and...
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Posted by admin on Feb 1, 2012 in |
A simple, precise and accurate UV-Spectrophotometric method has been developed and validated for estimation of secnidazole in bulk and tablet dosage form. It shows maximum absorbance at 313 nm with methanol and water (30:70). Estimation was carried out by A(1%1cm) and by comparison with standard. Calibration graph was found to be linear (r2 =0.09998) over concentration range of 1-4µg/ml. The proposed methods appear to be simple, sensitive, and reproducible when checked for parameters like accuracy, precision, limit of detection for routine determination of secnidazole in bulk as well as in tablet. The methods can be adopted in its routine...
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Posted by admin on Feb 1, 2012 in |
Starch was extracted from the grains of finger millet (Eleusine corocana), by steeping in water for 24 hours. The extracted starch was used as a disintegrant, at the concentrations of 2.5-12.5%w/w to compressed paracetamol tablet in comparism with maize starch BP. Results show that, there is no significant difference in the disintegration time or dissolution rate of tablets containing the two starches. Tablets containing Eleusine corocana met compendia requirements for disintegration time and dissolution rate. The starch is recommended as a disintegrant in tablet...
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Posted by admin on Jan 1, 2012 in |
Valsartan (VAL) and Hydrochlorothiazide (HTZ) are used in combination in treatment of Hypertension. Two simple, accurate, precise, economical and reproducible UV spectrophotometric methods have been developed for the estimation of Valsartan and Hydrochlorothiazide in Pharmaceutical formulation. Method I- Absorption ratio method (Q-analysis) using two wavelengths, 265nm (isobestic point at which both the drugs exhibit absorbance) 249nm (λmax of Valsartan) and Method II- Area under Curve method. For the second method Area under the Curve in the range of 249 -259nm and 261-281nm was selected for the analysis of Valsartan and Hydrochlorothiazide respectively. Linearity for detector response was observed in the concentration range of 2-24mg/ml & 2-14mg/ml for Valsartan and Hydrochlorothiazide respectively. The results of analysis have been validated statistically and by recovery studies the value of standard deviation was satisfactory and recovery studies ranging from 99.54 – 99.97 % for Valsartan and 99.75 – 101.04 % for Hydrochlorothiazide were indicative of the accuracy and precision of the proposed method The proposed methods were successfully applied for the determination of...
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