Posted by admin on Dec 1, 2011 in |
Aims: Qualitative analysis of a mucoadhesive polymeric (Carbopol940) suspension of Norfloxacin was carried out with the aim of developing an oral controlled release gastro-retentive dosage form. Methods: The characterization of ultrasonicated formulation was performed by Fourier Transform Infrared Spectroscopy (FTIR), Raman Spectroscopy, X-ray powder diffraction (XRD) and Scanning electron microscopy (SEM) analyses. For interpretation, FTIR (400 cm-1 to 4000 cm-1 region) and Raman (140 to 2400 cm-1 region) spectra were used. XRD data of pure drug, polymer and the mucoadhesive polymeric (Carbopol940) suspension were obtained using a powder diffractometer, scanned from a Bragg’s angle (2θ) of 10˚ to 70˚. In addition, dispersion of particle was studied using SEM techniques. Results: The results from FTIR and Raman Spectroscopic analyses suggested that in the mucoadhesive suspension, carboxylic groups of Norfloxacin and hydroxyl groups of C940 undergo chemical interaction leading to esterification and hydrogen bonding. The XRD data indicated that the retention of crystalline nature of Norfloxacin in the mucoadhesive suspension. Moreover, the SEM image analysis suggested that in the formulation maximum...
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Posted by admin on Dec 1, 2011 in |
The leaf of the plant Lawsonia inermis was examined for analgesic and anti-diarrhoeal properties. From the study of analgesic activity it was found that ethanol extract at a dose of 500 mg/kg exhibited no significant (p<0.3) inhibition of writhing reflex (28.45 % inhibition) while the inhibition of standard drug diclofenac sodium showed 82.7 % inhibition at a dose of 25 mg/kg body weight. The findings suggested that the leaf extract of Lawsonia inermis possessed anti-diarrhoeal activity at the dose of 500 mg/kg body weight compared to the control group and offered about 1.398 of the mean latent period for diarrhoeal episode to ensue and the result was significant...
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Posted by admin on Dec 1, 2011 in |
In present QSAR study of TIBO derivatives, aim of the author is to analysis some different 3D parameter in order to get best QSAR model, which enhance the binding affinity of TIBO derivatives. Solvent accessible surface area (3D) of all atoms with positive partial charge (strictly greater than 0) and Balaben 3D index plays vital role in this concern. This study focuses on some important and different 3D parameter in place of other conventional 3D parameter. The greater value of multiple R (= 0.9421) and lower value of Standard error (Se= 0.4981) shows that the find mathematical model is best fit and give the structural requirements of TIBO derivatives in particular sets of compounds to enhance the binding affinity of the...
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Posted by admin on Dec 1, 2011 in |
The present study was carried out to evaluate the antioxidant activity and phytochemical constituents of Boerhaavia diffusa Linn. (Nyctaginaceae) dried roots. The root extracts were prepared with chloroform, ethanol and water and screened for in vitro antioxidant activities by using assay of DPPH radical scavenging, antiproteolytic activity, polyphenol oxidase inhibition, hydroperoxide inhibition and ferric reducing power. The activity was compared with standard antioxidant like quercetin, salicylic acid, L-cysteine and ascorbic acid. Among these three extracts, ethanol extract has shows better antioxidant activity as compared to remaining two. Phytochemical screening of Boerhaavia diffusa L. root powder revealed the presence of carbohydrates, saponins, proteins, flavonoids, steroids, fats and...
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Posted by admin on Dec 1, 2011 in |
The essential oil of the aerial parts of Launaea nudicaulis was isolated using Clevenger’s apparatus and analyzed by GC/MS instrument. Different extracts of the aerial parts of Launaea nudicaulis were tested for their activity against Staphylococcus aureus and Escherichia coli. Seventeen constituents were identified in the essential oil. The major constituents in the essential oil are limonene, Z-citral and E-citral. The three polar extracts (hydro alcoholic, Ethyl acetate and butanol extracts) showed good activity against Gram +ve and Gram-ve bacteria. On the other hand, non-polar extracts (petroleum ether extract and chloroform extract) did not show any antibacterial...
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