Posted by admin on Feb 1, 2012 in |
The impact of salt stress and water stress on seed germination, root and shoot length, fresh and dry biomass, vigour index was investigated in Senna (Cassia angustifolia) at germination stage (7DAS). Salinity stress was induced by using NaCl and drought stress by using PEG-6000. Different concentration of NaCl (0.1 to 100 mM) and PEG-6000(-0.1 bars to -2.0 bars) were used for seed treatment. The objective of the present investigation was to study the comparatively impact of NaCl salinity stress and water stress on seed germination, seedling growth, fresh and dry weight in...
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Posted by admin on Feb 1, 2012 in |
Quinazoline and its analogues have important therapeutic value in the treatment of cancer to induce apoptosis in cancer cells in a proliferation-independent manner. The binding free energies of quinazoline based inhibitors of kinase were computed using linear interaction energy method with a surface generalized Born (SGB) continuum solvation model in the human ALK5 kinase domain. A training set of 20 quinazoline analogues was used to build a binding affinity model for estimating the free energy of binding for 12 inhibitors (test set) with diverse structural modifications. The root mean square error (RMSE) between the experimental and predicted activity values was 0.02 µM which is comparable to the level of accuracy achieved by the most accurate methods, such as free energy perturbation (FEP) or thermodynamic integration (TI). The correlation coefficient between experimental and predicted activity based on SGB-LIE estimation for the test set compounds is also significant (R2 = 0.9693). Low levels of RMSE for the majority of inhibitors establish the structure-based LIE method as an efficient tool for generating...
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Posted by admin on Feb 1, 2012 in |
A simple, sensitive and accurate spectrophotometric method has been developed for the deterrmination of Risperidone in raw material and capsule. The λmax of Risperidone was found to be 202nm. Risperidone obeys linearity within the concentration range of 2.5 to 20µg/mL and coefficient correlation was found to be 0.9991.The regression of the curve was Y= 0.0508X+0.0112. The %RSD value is below 2.0 for intraday and interday precision indicated that the method is highly precised. The percentage recovery value was higher than 100%, indicating the accuracy of the method and absence of interference of the excipients present in the formulation. The proposed method will be suitable for the analysis of Risperidone in bulk and pharmaceutical...
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Posted by admin on Feb 1, 2012 in |
Staphylococcus aureus causes a wide range of infection such as skin and soft tissue infection to life threatening disease like respiratory tract infection, musculoskeletal infection, endocarditis and urinary tract infection. The aim of the present study was to evaluate the possible protective effects of nanoconjugated vancomycin against VSSA infection on select makers of oxidative damage and antioxidant status in liver, kidney and spleen.A coagulase positive VSSAstrain was used for this study. VSSA infection was developed in Swiss mice by intraperitoneal injection of 5 X 106 CFU/ml bacterial solutions. Nanoconjugated vancomycin was treated to VSSA infected mice at a dose of 100 mg/kg b.w/day for 10 days. After decapitation, liver, kidney and spleen were excised from control and experimental groups, homogenized and used for different biochemical estimation. Nitrate level, myeloperoxidse activity, lipid peroxidation, protein oxidation, oxidized glutathione, DNA fragmentation level were increased significantly (p<0.05) in liver, kidney and spleen of VSSA infected group as compared to control group, and reduced glutathione level, activity of antioxidant enzymes (SOD and CAT), glutathione...
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Posted by admin on Feb 1, 2012 in |
The study aimed to access the analgesic effect of Feronia limonia (FL, leaves of Feronia limonia (L.) Swingle). The leaves of FL were extracted with 95% ethanol and the dried extract (FLE) was administered intragastically (i.g.) at 100, 200 and 400 mg/kg. Analgesic effect was evaluated in two experimental animal models. Pretreatment with single dose of FLE also produced dose-dependent anti-nociceptive effects in thermally and chemically induced mouse pain models. In addition, single dose of FLE at 2g/kg body weight produce no observable acute toxicity in mice within seven days. These results demonstrate that FLE possess analgesic effects and has no obvious acute...
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