Posted by admin on Nov 1, 2011 in |
Aim: To study In-Vitro sensitivity of Amphotericin B, Itraconazole and Fluconazole -Resistant against Candida albicans. Methods and Results: A panel of 14 clinical isolates of Candida albicans was tested. Strains were labeled and given a unique identification number. Candida albicans ITCC 4718 were included as quality control organisms in each set of experiments. Interactions in vitro between Amphotericin B, Itraconazole, Voriconazole, and Fluconazole against Itraconazole-resistant Candida albicans clinical strains were determined. Fluconazole and Voriconazole exhibited the most potent interactions with synergy against at least 50% of isolates, and the average fractional concentration index was 0.38 Conclusion: Fluconazole and Voriconazole exhibited the most potent interactions with synergy against isolates and Antagonism was not found for any combination. Significance and Impact of the Study: Fungal infections are frequently tricky to manage prudence has to be exercised in the use of antifungal drugs to capture any additional increase in the...
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Posted by admin on Nov 1, 2011 in |
A series of five membered heterocyclics was synthesized by the reaction between refluxing 2 – furoic acid with ethanol and conc. H2SO4. The obtained ester (2) with hydrazine hydrate and ethanol was refluxed to give hydrazides (3). Reaction of hydrazides (3) with different aromatic acids using phosphorousoxy trichloride (POCl3) lead to the formation of 2-Aryl -5-furyl -1, 3, 4-oxadiazoles [DM (1-6)], and was tested for their antioxidant activity. The synthesized compounds were characterized by IR, 1HNMR and Mass Spectroscopy. All the compounds were screened for in vitro antioxidant activity by DPPH method and nitric oxide scavenging assay. Among the synthesized compounds DM-1, DM-2 and DM-4 were found to be promising compounds of the series substituted with electron donating groups like methoxy and hydroxyl showed higher antioxidant...
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Posted by admin on Nov 1, 2011 in |
Comparative pharmacognostic and phytochemical studies are the reliable source to identify the genuine raw drug from its adulterants. This paper deals with the characterization of the repute ayurvedic drug hallakam from its substitute/adulterants. Ayurvedic experts equated rhizomes of Kaempferia rotunda L. of Zingiberaceae as hallakam and in certain market samples Lagenandra toxicaria Dalz. is also sold as hallakam. The distinguishing pharmacognostic and phytochemical characters evolved from the study help to detect the genuine and market adulterant of...
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Posted by admin on Nov 1, 2011 in |
Metal complexes of Au(III) with Thiosemicarbazone and Substituted Thiosemicarbazones different thiosemicarbazones have been synthesized. The present communication reports the structural study of the Au(III) complexes with Biacetyl Monoxime Thiosemicarbazones and these complexes have been characterized by elemental analysis, conductance, IR, NMR and Mass spectral data. The physicochemical and spectral data suggests tetrahedrol geometry for various complexes. Metal complexes of Biacetyimonoxtme thiosemicarbazone (BAMOT) and Substituted Thiosemicarbazones are also investigated for better comparison. Au(III) complexes of Biacetyimonoxtme thiosemicarbazone (BAMOT) and Substituted Thiosemicarbazones are also investigated for better comparison. The ligand and metal chelates would be screened in vitro for anticancer activity against some cancer Cell...
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Posted by admin on Nov 1, 2011 in |
The human oral cavity is a complex biological system in which members of a microbial community interact with themselves as well as with different host structures and components Neisseria sp., Haemophilus influenzae and Campylobacter jejuni cause periodontitis . The pathogenesis of this dental infection is a multi factorial process that results in a serious degenerative disease of the periodontium. Researches have resulted in the identification of important virulence factors. These researches have provided a narrow picture of the steps of this complex process. In contrast, a wider picture could be abstained with the application of tools such as bioinformatics and proteomics. These tools provide factors and process leading to the pathogenesis and treatment. In the present study Ferric binding protein is taken as a case study molecule to understand high reactive responses of various drugs administered for the oral periodontitis. The drugs are being compared with the Fbp. The Fbp interacted with doxycycline, flurbiprofen and chlorhexidine using docking...
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