Posted by admin on Jan 1, 2012 in |
Oral controlled drug delivery systems represent the most popular form of sustained drug delivery systems for the obvious advantages of oral route of drug administration. Such systems release the drug with constant or variable release rates. The oral controlled release systems shows a typical pattern of drug release in which the drug concentration is maintained in the therapeutic window for a prolonged period of time (sustained release), thereby ensuring sustained therapeutic action. They are used as single dosage form. Present work involves preparation and evaluation of sustained release of microspheres of Norfloxacin employing sodium alginate as natural polymer. The technique employed for microencapsulation of the drug is ionotropic...
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Posted by admin on Jan 1, 2012 in |
Fertility control is an issue of global and national health concern, many study have been done for the male contraception. The use of medicinal plants in different sorts of disease including fertility problem is widespread throughout the world. Though considerable progress has been made the development of highly effective, acceptable and reversible methods of contraception among females, progress possibilities on males are still slow and limited. With recent progress towards a better understanding of male reproductive physiology there is needed to develop new contraceptive modalities for male. Abrus precatorius is one of the folk medicinal plants widely used as an antifertility agent in varius places of south Asian countries including Chittagong region of Bangladesh. The aim of the present study was to investigate the antifertility activity of abrus precarious seed extract intraperitonially administered in adult swiss male albino mice. The intraperitonial administration of 40, 80 and 80 mg/kg body weight of ethanolic seed extract of Abrus precatorius shown a highly antifertility activity which done for two months. The lower...
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Posted by admin on Jan 1, 2012 in |
Rifampicin and Isoniazid microcapsules were prepared by phase seperation coacervation method for inclusion in suspension formulations. Ethyl cellulose was used as the coating material for microencapsulation. Developed microcapsules were characterized for visual appearance, photomicrography, sieve analysis, drug content, bulk density, ethyl cellulose content and drug release studies. Microcapsules were found to be irregular in shape, free flowing with wide particle distribution in the range of 178-422 µm with 75 % drug content. Both Rifampicin and Isoniazid microcapsules exhibited prolonged release with first order kinetics. Rifampicin and Isoniazid microcapsule suspension formulation was characterized for pH, viscosity, sedimentation rate and drug content. The developed suspension was found to be uniform with drug content between 99-100%. Stability studies indicated that Rifampicin and Isoniazid suspension formulation exhibited greater stability as compared to pure drug suspensions. Hence, Rifampicin and Isoniazid suspension exhibits a potential to be developed as controlled release paediatric and geriatric...
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Posted by admin on Jan 1, 2012 in |
The analytical method for the estimation of phytochemical active ingredients present in Garginia combogia extract, Green tea extract with calcium pantothenate for herbal formulations are evaluated for it’s Assay content and dissolution release. This herbal formulation with slim formula consists of several active ingredients such as Hydroxy Citric acid, catechins and calcium pantothenate. The HPLC method for the estimation of active content and the in-vitro dissolution release is developed for the...
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Posted by admin on Jan 1, 2012 in |
The present study is aimed at evaluating the in vitro antibacterial and antifungal activities of petroleum ether, chloroform, ethyl acetate, acetone, methanol, ethanol and water extracts of medicinal plant, Pyrus pashia were tested against (different gram positive and gram negative) ten bacterial strains and three fungal strains using by disc diffusion method. The different fractions of bark, fruit and leaf of Pyrus pashia, the ethanolic bark extracts of Pyrus pashia showed significant activity 17±1mm, 15±1mm and 14±1mm against Klebsiella pneumonia, Shigella flexneri and Escherichia coli. The medicinal plant fruit contain ash value, (total ash 1.10 ± 0.05%), moisture 60.36±0.25%, crude fat 1.62±0.20% and crude fiber 5.26±0.05%, extractive values were studied fresh part weight. The preliminary phytochemical analysis test showed the presence of carbohydrates (28.38±0.12%) and glycosides, alkaloid, flavonoids, saponins, tannins, unsaturated triterpenoids and sterol,...
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