Posted by admin on Nov 1, 2011 in |
Moringa preparations have been cited in the scientific literature as having antibiotic, antitrypanosomal, hypotensive, and antispasmodic, antiulcer, anti-inflammatory, hypo-cholesterolemic, and hypoglycemic activities, as well as having considerable efficacy in water purification by flocculation, sedimentation, antibiosis. To evaluate the antioxidant activity of Moringa oleifera leaf extracts and their in- vitro antibacterial activity against four microorganisms, viz. Escherichia Coli, Bacillus subtilis, Staphylococcus aureus and Salmonella typhii. Phytochemical screening of the leaf extracts in solvents of varying polarity; viz., water, methanol, ethanol and acetone were also carried out. The antioxidant activity of the extracts was determined by the reducing power assay using ascorbic acid as standard. Well diffusion method was used to assess the antimicrobial effect of the extracts on both Gram positive and Gram negative micro-organisms. Well known chemical procedures were used for the detection of the phytochemical components. The aqueous extract exhibited maximum antioxidant activity compared to the organic solvent extracts. Acetone extract showed broad spectrum antimicrobial effect against all the tested micro-organisms while the methanolic extract was active against...
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Posted by admin on Oct 1, 2011 in |
A number of 2-amino-4-(2′, 5′-dimethyl-3′-furyl)-6-(aryl)-pyrimidines 4(a-n) have been synthesized by treating the 1-(2′, 5′-dimethyl-3′-furyl)-3-(aryl)-2-propen-1-one (3a-n) with guanidine hydrochloride in presence of potassium hydroxide and ethanol. All these compounds were characterized by means of their IR, 1H NMR spectroscopic data and microanalyses. When these compounds were evaluated for anticancer activity, some of them were found to possess significant...
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Posted by admin on Oct 1, 2011 in |
Diabetes is a chronic metabolic disorder characterized by altered carbohydrates, fat and protein metabolism, and an increased risk of vascular complications. Swiss albino mice weighing 20-25g and albino rats (Wistar strain) weighing 170-190g of either sex were used for the studies. Mice used for toxicity and rats for anti-diabetic study. The aqueous roots extract of Murva was found to be safe at a dose of 2000mg/kg; hence a dose of 800mg/kg was used for anti-diabetic study. Diabetes was induced by alloxan monohydrate 150mg/kg i.p. After three days of injection of alloxan, diabetes was confirmed by monitoring its blood glucose level. Animals with blood glucose level more than 200mg/dl were taken for studies. Glibenclamide 20mg/kg i.p was taken as std. drug. The test possessed significant anti-diabetic activity (p<0.001) when compared to positive and negative control. Hence the roots extract of Murva may be value in patients with diabetes...
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Posted by admin on Oct 1, 2011 in |
The different extracts of the roots of Caesalpinia Bondue (Family- Fabeaccae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and chloroform extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 3h at a dose level of 250 mg/kg of body weight. The percentage protections by aqueous chloroform and ethanol extracts were 22.28 and 23% respectively. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerides, cholesterol and urea levels on 0,3,5,7 and 10th day. Both the extracts showed a significant anti- diabetic activity comparable with that of glibenclamide, standard anti-diabetic...
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Posted by admin on Oct 1, 2011 in |
The objective of the present study was to develop once daily controlled-release matrix tablets of Domperidone Maleate, an anti- emetic agent. Several formulations containing an anti- emetic agent (domperidone maleate) and hydrophilic polymers (Hydroxypropyl methylcellulose, Carbopol and Polyethylene oxide) were prepared by wet granulation methods. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability and in-vitro release studies. All the tablet formulation showed acceptable pharmacotechnical properties and complied with in house speciation for tested parameters. The results of dissolution studies indicate that formulation FH2 (Drug to HPMC, 1:0.50; purified water as granulating agent) could extend the drug release upto 24 hours. All the formulation exhibited diffusion dominated drug...
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