Posted by admin on Oct 1, 2011 in |
The present study was conducted to assess the anti-inflammatory, analgesic and cytotoxic properties of 50% ethanol extract of the stem bark of Terminalia arjuna plant on laboratory animal. In vitro cytotoxicity test was studied by Brine Shrimp Lethality Bioassay and results illustrated significant (p<0.05) cytotoxicity against A. salina, that were expressed as LC50. Terminalia arjuna ethanol extract showed brine shrimp cytotoxicity with lethal concentration 50 (LC50) value of 50.11μg/ml. Carrageenan-induced paw edema method was done to study the anti-inflammatory effect and it was found that T. arjuna can be effective in acute inflammatory disorders and in that case it showed significant result (p<0.001) with both of the 250mg/kg and 500mg/kg dose level. The extract was also used to evaluate the centrally acting analgesic potential using formalin, hot plate and peripheral pharmacological actions using acetic acid induced writhing test in mice. The extract of the plant were found to have significant (p<0.01; p<0.001) analgesic activity at the oral dose of 250 & 500mg/kg body weight, in the tested models. In...
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Posted by admin on Oct 1, 2011 in |
The powdered leaf of Vernonia galamensis (Asteraceae) is a herbal drug used in the treatment of diabetes mellitus in folk medicine in northern Nigeria. The crude aqueous extract of the leaves is deliquescent and usually stored in airtight desiccators. Efforts to use common diluents such as lactose, starch, and magnesium carbonate for tablet formulation of the extract produced tablets with defects such as “sticking” and “picking”. The purpose of this study was to use the Heckel and Kawakita equations to investigate the compressibility of the granules of the deliquescent crude extract of Vernonia galamensis prepared using gelatin a universally accepted pharmaceutical binder and selected efflorescent pharmaceutical diluents namely; Aerosil® 200, Avicel® PH 103 and calcium phosphate. The Kawakita model provided an excellent fit having higher R2 values than the Heckel model. The very low PK values of the Kawakita (indicating good fluidity) for all the different formulations made it preferable in explaining the compressibility of granules of the extract. The ranking for good compressibility based on the diluent type...
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Posted by admin on Sep 1, 2011 in |
This study was designed to present the observation of the pharmacological properties to the bulb of the plant. The extract of the bulb of Urginea indica Kunth. were collected by using of alcoholic extraction. The anti-inflammatory action of the alcoholic Extract of the bulb of the plant Urginea indica was evaluated in rats (female) against carrageenan induced edema i.e., using plethysmographic method. Besides this method, this extract was also assessed for Cotton pellet test and Hot plate test for anti-inflammatory and analgesic effects respectively. The effects of the extract were compared with the classical anti-inflammatory drug – Ibuprofen. The crude extract and the standard drug were orally administered. A significant anti-inflammatory effect was produced with the Alcoholic Extract of the plant part. This effect was then compared with the effect from the classical anti-inflammatory...
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Posted by admin on Sep 1, 2011 in |
Cordia dichotoma known as lasura, lisora, is a commonly known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic potential of methanol extract of fruits of Cordia dichotoma in glucose loaded animals and alloxan induced diabetic animals. In both the models Cordia dichotoma reduce the blood glucose level when compared to diabetic control group and exert a significant hypoglycemic and antidiabetic activity. However the potency of the herb was less than that of standard drug metformin. Cordia dichotoma methanol extract also reduced the rate of body weight loss in normal and alloxan induced diabetic animals. The results of this study revealed the presence of a significant antidiabetic potential of methanol extract of Cordia dichotoma in alloxan induced diabetic rats. On the basis of this further research work is needed to investigate exact mechanism of action and also to isolate the active constituent/s responsible for the...
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Posted by admin on Sep 1, 2011 in |
The present study was designed to investigate in vivo analgesic and cytotoxicity as well as in vitro antibacterial activities of the methanol: ethylacetate (1: 9) extract of the flowers of Peltophorum pterocarpum. Analgesic activity was assayed by acetic acid induced assay method wherein the extract showed moderate activity in a dose dependent manner. In respect of in vivo cytotoxicity, the flower extract of Peltophorum pterocarpum showed moderate activity with 30% cell growth inhibition against Ehrlich Ascites Carcinoma (EAC) cells at a dose of 50mg/kg. Moreover, Antibacterial test were done against five Gram-positive and four Gram-negative bacteria. Flower extract was active against all tested microbial species except Staphylococcus aureus and the zone of inhibition range was found to be 12±0.32 to 18±0.11...
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