Posted by admin on Aug 1, 2011 in |
In present study, a successful attempt has been made to develop a simple method for the simultaneous determination of ofloxacin and ornidazole using linear sweep Voltammetry (LSV) technique. Quantification of ofloxacin and ornidazole was done in Britton-Robinson Buffer of pH 5.5 using 0.1M KCl as a supporting electrolyte. Both ofloxacin and ornidazole exhibit reduction cathodic peak in given pH with peak potential at -1.30 V for ofloxacin and -0.42V for ornidazole vs. S.C.E. 0.1N HCl was used as Solvent for the analysis. The method was validated in the terms of its linearity, accuracy, precision, robustness, ruggedness, LOD and LOQ. Proposed method was found to be simple, precise, and accurate and can be successfully applied for routine quality control analysis and simultaneous determination of ofloxacin and ornidazole in combined drug formulations....
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Posted by admin on Aug 1, 2011 in |
The present work was carried out to design the floating drug delivery system to minimize the side effect, improve the prolongation of action, to reduce the frequency of administration. The objective of the present investigation was to develop a bilayer-floating tablet (BFT) and evaluate for domperidone maleate using wet granulation technology. HPMC, K-grade and effervescent sodium bicarbonate formed the floating layer. The release layer contained domperidone and various ratios of polymers such as HPMC-K100M.The floating behavior and in vitro dissolution studies were carried out in a USP paddle apparatus 2 in simulated gastric fluid. Final formulation released approximately 104% drug in 12 h in vitro, while the floating lag time was 4 min and the tablet remained floatable throughout all studies. Statistically significant differences were found among the drug release profile from different formulations Final formulation followed the Higuchi release model and showed no significant change in physical appearance, drug content, floatability or in vitro dissolution pattern after storage at 45°C/75% RH for three months. The release mechanism was...
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Posted by admin on Aug 1, 2011 in |
The quality control of herbal drugs and their extracts is essential when they are used as raw material for the development of herbal medicines. In this work, several techniques (pharmacopoeial and non-pharmacopoeial) were performed, aiming at establishing quality control parameters of the leaves of Heliotropium indicum L. (Boraginaceae), a shrub popularly known as stinker (fedegoso) in Brazilian northern and northeastern regions. The results determined the physicochemical characteristics of the drug and the tincture of the leaves. They also showed that the values obtained are in accordance with the data found in the literature for plant material. Preliminary phytochemical analysis of the leaves demonstrated the presence of phenols, tannins and alkaloids. The chromatographic profile showed the presence of a common substance in the hexanic and alkaloidal...
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Posted by admin on Aug 1, 2011 in |
PURPOSE: The aim of this retrospective study is to present data of patient characteristics, treatment patterns, and treatment results in an unselected patient population with small cell lung cancer (SCLC) in limited disease (LD) and extensive disease stage (ED). MATERIAL AND METHODS: All patients of carcinoma lung from April 2007 to December 2009 were analyzed for present study, conducted in department of radiotherapy, PGIMS Rohtak, Haryana. Total diagnosed lung cancer patients found were 531, out of which 41 patients were having small cell lung cancer (SCLC). These patients have been analyzed with respect to patient characteristics, chemotherapy, radiotherapy, and treatment outcome. RESULTS: Twelve (29.27%) of all patients had LD SCLC. Mean age of patient was 58.9 years. Two (5.55%) patient had complete response (CR). Rest 32 (77.77%) patients had partial response. Seven (16.66%) patients did not turn up after treatment. Consecutive thoracic palliative radiotherapy was given in 22 (53.65%) patients. Additional prophylactic cranial irradiation (PCI) was administered to two patients. Sixteen patients (39.02%) received CT with Carboplatin and Etoposide and three (7.32%)...
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Posted by admin on Aug 1, 2011 in |
The fruit extract of C. metuliferus was evaluated for its phytochemical and histopathologic properties. Phytochemical screening showed the presence of alkaloids, flavonoids, tannins, sterols, saponins and cardiac glycosides. The histopathological effects of C. metuliferus fruit extract on the liver, kidney, spleen and pancreas of male adult albinos rats were investigated after daily oral administration for 28 days. The histological examination of rats administered 1000mg/kg of C. metuliferus fruits extract showed focal hepatocellular necrosis similar to that produced by paracetamol overdose. Necrosis of the epithelial cells of the kidney tissues was also observed in rats administered 1000mg/kg of C. metuliferus fruit. These observations suggest that daily oral administration of 1000mg/kg of C. metuliferus fruit extract for 28 days was associated with tissue damage of liver and kidney of the...
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