Posted by admin on Aug 1, 2011 in |
In continuing search for compounds with immunomodulatory activity, plant Aralia cachemirica has been found to contain continentalic acid (CA). Isolation of this pharmacologically significant diterpinic acid from Aralia cachemirica is novel. Chemical structure of this compound was identified by spectral analysis as (-)-pimara-8(14), 15-dien-19-oic acid, which has been isolated from A. cordata and A. continentalis. This compound has been evaluated for its effect on immunomodulaion. CA was found to inhibit production of pro-inflammatory cytokines (IL-6, TNF-α) & nitric oxide (NO) in LPS induced macrophage activation, suppressed antibody titres & delayed type hypersensitivity reaction (DTH) when orally administered and increased the phagocytic activity by clearance of Candida albican infection from peritoneal cavity in mouse model...
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Posted by admin on Aug 1, 2011 in |
A simple procedure is reported for the synthesis of Cefotaxime Sodium from an isolable activated ester, diethyl thiophosphoryl [(Z)-(2-aminothiazol-4-yl)-2-(methoxyimino) acetate (DAMA) and 7-ACA (7-Aminocephalosporinic acid). DAMA was synthesized from ATMA [(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetic acid] and DHP [O, O-diethyl O-hydrogen phosphorothioate], which was treated with 7-ACA and chloroform. A 95% pure Cefotaxime acid was obtained; upon further treatment of Cefotaxime acid with 2-ethyl hexanoate, 98.4 % pure Cefotaxime Sodium was obtained. The synthesized material was identified by Infrared spectroscopy & validated High Performance Liquid Chromatographic (HPLC) method and also quantified by HPLC method....
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Posted by admin on Aug 1, 2011 in |
Antibiotics are not chemically stable in water based oral pharmaceutical suspensions. Anhydrous liquid antibiotic suspension for oral administration provides a product having good shelf life and taste characteristics relative to conventional liquid formulations. A ready to use oil based cefpodoxime proxetil preparation which can be stored at room temperature was prepared and evaluated for its organoleptic properties, viscosity, flow behavior and accelerated physical and chemical stability. The formulation showed improved redispersibility, good taste masking of the bitter drug and allows the product to be stored longer preventing hydrolysis of the...
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Posted by admin on Aug 1, 2011 in |
Urinary tract infections are common type of pathogenic infections in body. Essential oils of Coleus aromaticus and two varieties of Ocimum sanctum (Rama Tulasi and Shyama Tulasi) were compared for antibacterial activity against urinary tract infection (UTI) causing bacteria; Staphylococcus aureus, Klebsiella oxytoca, Proteus vulgaris, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Proteus mirabilis. Ocimum sanctum (Rama Tulasi) and Coleus aromaticus oils showed remarkable activity, later being more active. Least activity was observed in Shyama Tulasi variety of Ocimum sanctum. Constituents of the oils were analyzed by GC-MS and GC-FID. The essential oils have promising inhibitory effect with minimal inhibitory concentration (MIC) ranging from 0.5μl/ml -6μl/ml. The essential oils of two varieties of Ocimum sanctum have differences both in chemical composition and MIC values against UTI infection causing...
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Posted by admin on Aug 1, 2011 in |
Many patients are express difficulty in swallowing tablets and hard gelatin capsules tending to non compliance and ineffective therapy. In the present work, fast dissolving tablets of metoprolol tartrate are formulated with a view to enhance the patient compliance. It is suited for tablets undergoing high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to minimize side effect. Hence the main objective of the study was to formulate fast dissolving tablets of Metoprolol tartrate to achieve a better dissolution rate and further improving the bioavailability of the drug. These tablets prepared with a various concentration (4%, 5%, 6%w/w) of superdisintegrants such as crosscarmellose sodium (CCS), crosspovidone (CP) and pregelatinized starch (PGS) along with directly compressible mannitol to enhance mouth feel. The prepared tablet were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, wetting time, water absorption ratio and in- vitro dispersion time, in- vitro disintegration and in- vitro dissolution profile are found satisfactory. Among the nine formulations, the formulation F9 containing pregelatinized starch...
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