Posted by admin on May 1, 2011 in |
Familial cancers, which are in general incapable of exhibiting symptoms at the early onset period of the disease, can become fatal if left undiagnosed. Such cancers turn out to be a great threat through many generations in the long run. The remedial alternative to this is treatment at the genetic level which quite obviously points out to gene therapy. In this work, gene therapy proposed at the pre-transcriptional level intends to silence mutation of the target gene, thereby inhibiting or silencing gene expression in the form of a defective protein. Skin cancer, the second most common type of cancers widespread across the globe, has been considered for our studies. Phytochemicals that have been reported to have anti-skin cancer properties (at the protein level – acting on the defective protein targets), have been further investigated for antimutagenic activity at the gene level (intended to act on gene targets). Lutein and crocetin have been reported to show antimutagenic behavior towards the skin cancer genes considered in the analysis. Considering the drug-likeness...
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Posted by admin on May 1, 2011 in |
The aim of work is to characterization and evaluation of fast dissolving tablet of Granisetron hydrochloride using three superdisintegrants like crosscarmellose sodium, crosspovidone and sodium starch glycolate. FTIR studies revealed that there was no physico-chemical interaction between granisetron hydrochloride and other excipients. The tablets were prepared by dry granulation method and all had the same amount of ingredients except, the superdisintegrant level. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, disintegration time and in-vitro dissolution study. Tablet containing crosspovidone showed excellent disintegration time and drug release as compared to other...
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Posted by admin on May 1, 2011 in |
Schwannomas are usually benign tumors that result from the proliferation of the perineural cells. Since these tumors are very rare, misdiagnosis is common. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. We present a case of nineteen years old primigravida with 22 weeks pregnancy with an adnexal mass. The diagnosis of schwannomas was made on laprotomy and confirmed on histopathological examination. The case is reported not only due to its rarity but due to its association with pregnancy and its successful outcome....
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Posted by admin on May 1, 2011 in |
Levetiracetam is a new antiepileptic medication that is effective as adjunctive therapy in the treatment of partial onset seizures in adults and children 4 years of age and older with epilepsy. Levetiracetam is an antiepileptic drug available as a clear, colorless, grape-flavored liquid (100 mg/mL) for oral administration. It is the S-enantiomer of etiracetam, structurally similar to the prototypical nootropic drug piracetam. Levetiracetam shows great potential as a safe and effective agent for the treatment of neonatal seizures based on its efficacy and safety profile in other age groups, its mechanism of action is still not much known. Materials and Methods: The method development and its validation were performed on Agilent’s gas chromatographic system equipped with Flame Ionization detector and head space analyzer. The method involved in SPBTM– 624, Supelco, 60 m length, 0.32 mm internal diameter, and 1.8 µm film thickness column using nitrogen gas as a carrier. The flow rate was 1.5 mL per minute and flame ionization detector (FID) was used. Results: During method validation, parameters...
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Posted by admin on May 1, 2011 in |
The present work is to evaluate the anxiolytic activity of a hydroalcoholic extract of Tephrosia purpuria (L) Pers (HAETP) in mice using the elevated plus-maze (EPM), elevated zero-maze (EZM), Y-maze and hole-board models. Furthermore, the anxiolytic effects of HAETP were compared to a known active anxiolytic drug diazepam. The extract, administered orally, in two different doses of HAETP 200 mg/kg and 400 mg/kg, was able to increase the time spent and the number of arm entries in the open arms of the elevated plus-maze and elevated zero-maze, as well as decrease the visits by mice in the Y-maze, also significantly increase nose poking, line crossing and rearing in hole-board. This effect was comparable to that of the diazepam (2.0 mg/kg i.p.). These results indicate that hydroalcoholic extract Tephrosia purpuria (L) Pers is an effective anxiolytic...
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