Posted by admin on May 1, 2011 in |
In the present study we have explored the effect of Urtica dioica, a traditional antidiabetic herb used in India and Bangladesh, on insulinemic and chronic inflammatory status of type 1 diabetic model rats. The mature and fresh leaves of U. dioica was collected from the mountain range of Assam in India and the water extract of the leaves was used at a dose of 1.25g/kg body weight. Adult Long-Evans male rats, bred at BIRDEM Animal house, were used in this study. Type 1 DM was produced with single intraperitoneal injection of Streptozotocin using standardized methods. The experiment for semi-chronic effects was done with continuous feeding of water extract of U. dioica for 8 days. Serum glucose estimated by glucose oxidase (GOD-POD) method, serum insulin was measured by ELISA and CRP (as a marker for chronic inflammation) was also measured by an ELISA technique specific for rats. Serum lipids were measured by enzymatic-colorimetric methods. When compared to Control the water extract of U. dioica showed a significant hypoglycemic effect on...
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Posted by admin on May 1, 2011 in |
Ampicillin is used to treat variety of Bacterial infections in Humans. Piperine, an alkaloid from Piper species is reported to enhance oral bioavailability of co-administered drugs. The present study was aimed to include to Piperine (bioenhancer) as a formulation additive in oral formulations of Ampicillin Trihydrate. So, a Physical mixture of Ampicillin Trihydrate and Piperine (1:1) was tested for their compatibility by DSC, TLC and FT-IR techniques. Stability of the mixture was assessed by the use of ICH guidelines. The above studies have proved that Piperine can be used as a formulation additive (bioenhancer), in oral formulations of Ampicillin...
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Posted by admin on May 1, 2011 in |
Quercetin is the most abundant natural flavonoid, present in medicinal plants. Quercetin is of interest because of its pharmacological function. Quantification of quercetin from the dried leaves of Melia azadirachta and Murraya koiengi was carried out based on chromatographic separation. Sensitive, simple, and accurate high-performance liquid chromatographic method has been established for detection of quercetin in Melia azadirachta & Murraya koeingi dry leaf...
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Posted by admin on May 1, 2011 in |
Familial cancers, which are in general incapable of exhibiting symptoms at the early onset period of the disease, can become fatal if left undiagnosed. Such cancers turn out to be a great threat through many generations in the long run. The remedial alternative to this is treatment at the genetic level which quite obviously points out to gene therapy. In this work, gene therapy proposed at the pre-transcriptional level intends to silence mutation of the target gene, thereby inhibiting or silencing gene expression in the form of a defective protein. Skin cancer, the second most common type of cancers widespread across the globe, has been considered for our studies. Phytochemicals that have been reported to have anti-skin cancer properties (at the protein level – acting on the defective protein targets), have been further investigated for antimutagenic activity at the gene level (intended to act on gene targets). Lutein and crocetin have been reported to show antimutagenic behavior towards the skin cancer genes considered in the analysis. Considering the drug-likeness...
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Posted by admin on May 1, 2011 in |
The aim of work is to characterization and evaluation of fast dissolving tablet of Granisetron hydrochloride using three superdisintegrants like crosscarmellose sodium, crosspovidone and sodium starch glycolate. FTIR studies revealed that there was no physico-chemical interaction between granisetron hydrochloride and other excipients. The tablets were prepared by dry granulation method and all had the same amount of ingredients except, the superdisintegrant level. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, disintegration time and in-vitro dissolution study. Tablet containing crosspovidone showed excellent disintegration time and drug release as compared to other...
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