Posted by admin on Apr 1, 2011 in |
Objective – Crataeva magna is a potent medicinal plant in the Indian systems of medicine. Traditionally used for inflammation, fever, arthritis, bronchitis, urinary calculi and cough. The objective of the present work was to study the antipyretic activity of plant Crataeva magna (Lour.) DC belonging to family Capparaceae. Materials & Methods – In the present study the alcoholic extracts of the bark of Crataeva magna were studied for their antipyretic activity by TAB (Typhoid) vaccine-induced pyrexia in rabbits. Result – In TAB vaccine-induced fever, the fever was significantly reduced and the body temperature was normalized by administration of 200 and 400 mg/kg dose orally and the property was comparable to the reference drug. Conclusion – this study has established the antipyretic activity of Crataeva magna and thus, justifies the anecdotal, folkloric and ethnomedical uses of this plant for...
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Posted by admin on Apr 1, 2011 in |
In the present work, oral dispersible tablets of cinnarizine were prepared by direct compression method with a view to enhance patient’s compliance. Five different superdisintegrants viz. crosspovidone, sodium starch glycolate, crosscarmellose sodium and low-substituted hydroxypropylcellulose (L-HPC) and pregelatinized starch were used along with microcrystalline cellulose (Avicel PH 102) and directly compressible mannitol (pearlitol SD-200) which enhances the mouth feel. Fifteen formulations having superdisintegrants at different concentration levels were prepared. These tablets were evaluated for drug content, weight variation, friability, hardness, wetting time and in vitro disintegration time. Among the formulations tablets of batch F9 containing crosspovidone (at 4.5% level) showed superior organoleptic properties along with excellent in-vitro disintegration time and drug release as compared to other formulations. It was concluded that superdisintegrants addition technique is a useful method for preparing oral dispersible tablets by direct compression method....
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Posted by admin on Apr 1, 2011 in |
Cressa cretica is halophytic plant belongs to family Convolvulaceae, growing extensively all over India. The entire plant is medicinally important and used extensively in traditional system of medicine. The present work attempted to summarize the macroscopic characters of the plant Cressa cretica. The microscopic characters, physical constant values, extractive values, fluorescent analysis of the plant were carried out. Preliminary phytochemical screenings of extracts were also performed. The present investigation contributes to establish the Pharmacognostic profile of the medicinally effective...
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Posted by admin on Apr 1, 2011 in |
In the present study Rizatriptan benzoate, which is the bitter drug requires taste, masking. β- Cyclodextrin is used in taste masking, which improves the patient compliance and also increases the rate of dissolution. Solid dispersion of drug and β- Cyclodextrin were prepared which was optimised in 1: 8 ratios, which gave satisfactory results for taste masking. This was then characterised using Differential scanning colorimetry (DSC), X-ray diffraction (XRD) and Infra Red (IR). The prepared solid dispersion was then formulated into tablets using varying concentrations (0-30%) of sublimating agents. The sublimating agents used were camphor and ammonium bicarbonate. The formulated powder blend was evaluated for angle of repose, bulk density, tapped density, Carr’s index. These powder properties showed good flowability. Tablets were formulated by direct compression. The sublimation process produced pores into the tablets, which allowed easy penetration of dissolution media followed by rapid release of the drug, which is the major aim of melt-in-mouth tablet dosage form. The tablets were evaluated for hardness, friability, disintegration time (in vitro, in...
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Posted by admin on Apr 1, 2011 in |
The present study was carried out to investigate the effect of oral feeding of A. indica leaf (powder, aqueous and 80% ethanol extract) in STZ induced type 2 diabetic rats. Diabetes was induced by single intraperitoneal injection of STZ to 48hrs old pups and experiments were carried out three months later. For chronic experiment type 2 rats were divided into 5 groups: 1) Water control, 2) Glibenclamide (5gms/kg b.w.) treated, 3) A. indica powder [mixed with rat feed (1.25 g/kg b.w.)], 4) Aqueous extract and 5) 80% ethanol extract treated. The test drugs were used at a dose of 1.25 g/kg b.w. for 28 consecutive days. Body weight was checked every week. Blood was collected by cutting the tail tip at the beginning and on the days 7, 14, 21 and by decapitation on the 28th day. Results of the experiment showed that A. indica leaves exerted a gradual reduction in serum glucose level of type 2 diabetic rats. A significant reduction in serum glucose level was noticed on...
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