Posted by admin on Jun 30, 2023 in |
Introduction: Ultrasound-guided axillary brachial plexus block is commonly used for forearm and hand surgery. Perineural dexamethasone 8mg has proved to prolong the duration of analgesia, but studies with low doses of dexamethasone are scarce. Hence this study was designed to determine the duration of analgesia with 2 mg dexamethasone used perineurally with ropivacaine. Methods: Fifty-Eight patients scheduled for forearm and hand surgeries were included in our study and randomly allocated into two groups. Group R- Axillary Brachial Plexus Block given with 0.75% Ropivacaine 18 ml and 2ml NS and Group RD- Axillary Brachial Plexus Block given with 0.75% Ropivacaine 18 ml and 2 mg Dexamethasone making a total volume of 20ml. Results: Four patients were excluded because of block failure. The time of first rescue analgesia in Group RD was 515.74±11.07 minutes and in Group R was 452.78±14.76 minutes and was statistically significant. Onset of sensory block and motor block in Group RD was earlier than in Group R and duration of sensory and motor block was also longer...
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Posted by admin on Jun 30, 2023 in |
Objective: To assess self-medication practices among healthcare workers in the context of the Covid-19 pandemic in a tertiary care teaching hospital of north India. Background: Self-medication practice is a common phenomenon worldwide but has been reported to be very common in developing countries like India. Self-medication practices have gained more significance with the emergence of the Covid-19 pandemic worldwide. When consumers self-medicate without consulting the caregiver, safety issues and irrational use of drugs arise. Material and Methods: This was a cross-sectional questionnaire-based observational study conducted among healthcare workers in a tertiary care teaching hospital. A questionnaire elucidating details of self-medication regarding the history of self-medication, type of self-medication used, and reason for taking self-medication in the context of Covid-19, etc., was provided to healthcare workers from different healthcare professional cadres. Descriptive statistics did a statistical analysis of the data. Results: The present study found that the overall prevalence of self-medication for the prevention and treatment of Covid-19 was 47.8%. The contributing factors for self-medication in the context of Covid-19...
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Posted by admin on Jun 30, 2023 in |
Antibiotic or antifungal drug resistance is a major challenge in this era. Because the discovery and development of new drugs takes a long time. So, ancient medicine formulations are being checked for antimicrobial properties. Red ochre triturated with Punica granatum (Dadim bhavit gairikvati) is herbo-mineral formulation prepared by red ochre (Gairika/Ferric Oxide fe2O3) triturated with Punica granatum (Dadima-pomengrate juice). The process is done according to the classical text Sharangadhara Samhita. This formulation is useful in naushea, vomiting, hyperacidity, anemia, piles, anorexia, diarrhea, burning micturation, etc. Analytical testing shows normal results within the standard range. The formulation is tested with reference to standard drugs for antibacterial study as two types of gram positive bacteria, viz. Staphylococcus aureus and Bacillus subtilis, and two types of gram negative bacteria, viz. E. coli and Proteus mirabilis. Two fungi, named Candida albicans and Aspergillus niger are also tested again with the same formulation. Five batches of samples for each organism are tested. A statistical tool such as the mean (a measure of central tendacy) is used for...
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Posted by admin on Jun 30, 2023 in |
Modern phytochemical analysis in terms of fingerprinting of different bioactive phytoconstituents in the roots of Leptadenia reticulata and whole herb of Cocculus hirsutu belonging to the family Ascelpidiaceae and Menispermaceae respectively. High-performance liquid chromatography (HPLC) analysis of roots of Leptadenia reticulata and whole herb of Cocculus hirsutus were carried out to develop the fingerprint and verify the presence of standards such as Gallic acid, Catechin, Rutin, Quercetin and Kaempferol in the plant extract. RP-HPLC was performed on an Agilent 1260 Infinity equipped with Inertsil ODS 3V (250 mm x 4.6 mm), 5 µm as a stationary phase, by injecting 20 µL of the sample (1µg/mL) at the flow rate 1.5 mL/min and temperature 30⁰C using mixture of Mobile Phase A consist of 1 % Ortho phosphoric acid in water and mobile phase B consist of acetonitrile (20:80) with 60 min run time and the spectra were measured at 364nm using UV detector. The retention time of standard Gallic acid, Catechin, Rutin, Quercetin and Kaempferol were 6.4 min, 10.8 min,...
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Posted by admin on Jun 30, 2023 in |
According to ICH guidelines, an easy, cost-effective, accurate, and precise RP-HPLC method for simultaneously determining Remogliflzin and Teneligliptin was developed and validated. The drug’s quantity was determined using a photodiode array (PDA) detector. The column was run in isocratic mode with mobile phase acetonitrile and ammonium phosphate buffer at a 40:60 ratio. The flow rate was one milliliter per minute and effluent was measured at 245 nm. The retention times were 2.719 and 7.337 min for Remogliflzin and Teneligliptin respectively. The injection volume was 10µl. as per ICH guidelines the method was validated and the method was found to be linear in the range of 25-150µg/ml for Remogliflzin and 2.5-15µg/m for Teneligliptin. Percentage recovery studies of Remogliflzin and Teneligliptin100.2% and 100%. The LOD & LOQ was found to be 0.3 & 1µg/ml for Remogliflzin and 0.03 & 0.1µg/ml for Teneligliptin. The values of precision and robustness lie within the acceptance limit. Thus, the simultaneous determination of Remogliflzin and Teneligliptin using the suggested method can be successfully employed in routine...
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