Posted by admin on Jan 1, 2011 in |
The purpose of this study was to improve the solubility of poorly soluble Carbamazepine by using solid dispersion technique utilizing common pharmaceutical polymers. The formulations were prepared with HPMC, PVP K30, and poloxamer 407 as polymers and methanol as solvent. The formulations were characterized by differential scanning calorimetry, Fourier transform infrared spectroscopy, in vitro dissolution study by USP type I apparatus, and recrystallization study by optical microscopy. The dissolution profiles revealed that the drug and polymer ratio and the type of polymer both play critical role in solubility enhancement. The solid dispersions formulated with drug and poloxamer ratio of 1:1 showed highest dissolution rate. The formulations containing PVP did not show any endothermic peak of the drug unlike other formulations. There were molecular interactions between drug and polymers (HPMC and PVP) which were confirmed by FTIR...
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Posted by admin on Jan 1, 2011 in |
Recent studies have provided relevant scientific support for the use of C. membranaceus root in the treatment of prostate cancers. In the current study, we formulated both liquid and solid oral dosage forms from the ethanol extract of C. membranaceus root and investigated their physicochemical properties, release effects and suitability in comparison with the currently used aqueous decoctions and directly powdered plant material, in order to determine the most appropriate and suitable dosage form that will maximize the benefits of therapy with this species. The prepared solution from the ethanol extract had characteristics similar to the aqueous decoction, but unlike the later, it maintained its specifications and stability throughout the period of study. However, the use of large volumes, convenience and suitability for long term use, will limit their application. The assessed properties of the prepared tablets and capsules met all the specifications required for good quality and they can be used in simple and convenient doses of one tablet or capsule, three times a day, in place of...
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Posted by admin on Jan 1, 2011 in |
Nigella sativa L. (Black cumin) has showed a broad spectrum of pharmacological effects like antipyretic, analgesic, anti-inflammatory and antimicrobial. These activities may be related to the seeds oil. The most important chemical composition of hexanic extract of seeds was unsaturated fatty acids and essential oil. In this investigation the hexanic extract of seeds was topically applied to evaluate the healing efficiency of seeds oil on the second degree burn wound models in rats. Animal were randomly divided into three groups of six for each group. Silver sulfadiazine was applied as an antiseptic standard drug. Wound healing was assessed by the rate of contraction and histological characteristics in treated and untreated groups. On day 12, the extract-treated animals showed 81.20% reduction in the wound area and were significantly (P<0.05) more than control group 63.31%. Histological study showed fully grown regenerated epidermis on day 12 in treated rats. The present study suggests the burn wound healing action of seeds may be due to anti-inflammatory, antioxidant and antimicrobial activities of major compounds...
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Posted by admin on Jan 1, 2011 in |
Psidium guineense Swartz is a shrub native to Brazil. It is consumed in natura or in the form of pulp, which presents a high content of C vitamin and proteins. The chemical prospection of the aqueous extracts from unripe and mature pulp revealed the presence of tannins and flavonoids. The extracts demonstrated moderate antibacterial activity against the most of strains tested, and the best result was obtained with the unripe pulp extract against Staphylococcus aureus (MR358; MIC 256 μg/mL). The extracts were further tested for in vivo brine shrimp lethality test. The mature pulp extract exhibited significant toxicity (LC50=125...
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Posted by admin on Jan 1, 2011 in |
The aim of the present study was to carry out phytochemical screening and anticonvulsant activity of various extracts of the whole parts of Wedelia chinensis. The extracts (Petroleum ether, Ethanolic & Aqueous) were subjected to various chemical tests in order to identify the main phytoconstituents of the plant. The results of the present investigation revealed that the ethanolic extract contains glycosides and little amount of alkaloids and flavonoids, petroleum ether extract indicates the presence of steroids and aqueous extract was rich in glycosides and saponins. The anticonvulsant activity of ethanolic and aqueous extract of whole plant of Wedelia chinensis at a dose level of 250, 500, 750 mg/kg b.w, p.o. was performed in mice by using MES and PTZ methods. Phenytoin was used as a reference compound (25mg/kg b.w, i.p). Seizures were induced by delivering electroshock of 50 mA for 2 seconds by means of electro convulsiometer through a pair of ear clip electrodes whereas in PTZ model, PTZ at the dose of 80 mg/kg was injected i.p. to...
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