Posted by admin on Aug 1, 2010 in |
The objective of the present investigation of hepatoprotective activity of various Fruit extract of Semecarpus anacardium in paracetamol induced liver damage model in Wistar rats. Liver damage was produced by paracetamol (2gm/kg, p. o.) in 1% CMC. The Plant extracts (200mg/kg, p. o.) were administered every 24 hrs for seven days, while standard group received N-acetyl l- cysteine. At the end of the study the marker enzymes in serum were analyzed. The aqueous as well as alcoholic extract showed significant hepatoprotective activity and efficacy of alcoholic extract was almost comparable to that of N-acetyl l-...
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Posted by admin on Aug 1, 2010 in |
Novel 2- Aminothiazole derivatives were synthesized by the reaction of 2-aminothiazole (1) with chloroacetylchloride in presence of K2CO3 in chloroform afforded 2- chloro- N- (thiazol – 2- yl) acetamide (2). Compound (2) on condensation with substituted phenols in presence of K2CO3 in acetone afforded the title compound (3a-g). The chemical structures of the synthesized compounds were elucidated on the basis of IR, 1H NMR data. The synthesized compounds were screened for antibacterial and antifungal activity among them the compound 3c and 3d have shown significant inhibition of bacterial and fungal growth....
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Posted by admin on Aug 1, 2010 in |
An oral monolithic osmotically controlled delivery system for Nifedepine using asymmetric membrane technology was developed and evaluated. Unlike conventional osmotic systems, which require laser drilling, this system releases the drug in a controlled manner from asymmetric membrane coated core tablets. Asymmetric membrane is formed by dry process with phase inversion technology process using cellulose acetate as the coating material. Higher water influx of this membrane aids in delivery of Nifedepine, which is highly water insoluble with low osmotic pressure. The porous structure of the membrane was confirmed by scanning electron microscopy. Influence of different osmotic agents on drug release was evaluated. In vitro release studies showed that as concentration of osmotic agents was increased, the drug release was also enhanced. Drug release from the developed monolithic system was independent of external agitation and pH of dissolution media. Comparative in vitro release data was obtained using different types of coating membranes like controlled porosity membrane and dense coating membrane with mechanically drilled orifice. Osmotic pressure generated in the system was...
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Posted by admin on Aug 1, 2010 in |
Six generic ciprofloxacin HCl 250 mg tablets from different manufacturer have been evaluated to assess their bioequivalence using in vitro tests. Other general quality assessments of these tablets like assay, weight variation, hardness, friability, disintegration time were also determined and all these generic tablets passed compendial specifications. There were no significant differences (p < 0.05) in the percentage dissolution of drug from generic tablets at 15 minutes with the same from innovator brand tablet at the same time point. To compare the dissolution profiles of all the tablet formulations and the innovator brand, a model independent approach of difference factor (f1) and similarity factor (f2) was employed with all time points included in the in vitro dissolution studies. These results indicated that all generic ciprofloxacin HCl tablets included in this investigation were bioequivalent with the chosen innovator brand and so may be used interchangeably....
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Posted by admin on Aug 1, 2010 in |
The retrospective study on prescribing patterns of antihypertensives showed that the prevalence of hypertension was predominantly more with male patients than in female patients. It was also found that the average age of the overall study population was 56 years. The average age of the population clearly indicates the elderly patients were affected more. The results indicates that around 57.6% of the patients were brought to normal or prehypertension after the successful treatment with antihypertensive agents. The remaining 42.4% were brought to high normal after the treatment. The study revealed that the physician were treated 44.73% of the patients population with Ramipril alone as mono therapy, 21.05% were treated with Atenolol, 10.52 % were treated with Amlodipine, and other patients are treated with Amiodarone, Prazonin HCL, and Telmisarten etc. The most commonly prescribed combination was found to be Ramipril with Atenolol and it is followed by Ramipril with Amlodipine. The overall percentages of these combinations were found to be 37.25 % and 25.0%...
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