Posted by admin on Apr 1, 2010 in |
In present study, in vitro methods were selected to test and compare the antioxidant activity at different levels involving formation and scavenging of free radical by extract of Butea monosperma flowers (EBMF). The total phenolic content of EBMF was found to be 19.09 mg (equivalent to gallic acid) per gram of extract. In addition, reducing power was found to be increase with the increasing concentration of extract. The extract exhibited concentration dependant radical scavenging activity in DPPH with IC50 value- 47. 2 µg/ml. All the above in vitro studies clearly indicate that the EBMF posses a significant antioxidant...
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Posted by admin on Apr 1, 2010 in |
Anti-inflammatory activity of the ethanolic extract of the Cissampelos pariera Linn leaves was studied in albino wistar rats using the carrageenan induced rat paw edema model. The ethanolic extract of Cissampelos pariera (400 mg/kg p.o.) inhibited carrageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indicated that the extract produced significant (P < 0.05) anti-inflammatory activity when compared with the standard drug indomethacin (10 mg/kg p. o.) and untreated...
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Posted by admin on Apr 1, 2010 in |
Ofloxacin is a fluoroquinolone antibiotic considered to be a second-generation fluoroquinolone. Ofloxacin is administered by oral, intravenous or topical (eye and ear drop) route. It is used as antibacterial for the treatment of various diseases like chronic bronchitis, pneumonia, urethritis, cervicitis, urinary tract infections, prostatitis, uncomplicated urethral and cervical gonorrhea. Ofloxacin is a pale yellow or bright yellow, crystalline powder. It is slightly soluble in water, soluble in glacial acetic acid, slightly soluble or soluble in methylene chloride, slightly soluble in methanol. A simple Nanodrop spectrophotometric method was developed for the determination of Ofloxacin in pure and its pharmaceutical tablet dosage form. Ofloxacin exhibiting λ max at 296 nm in mobile phase (0.05 M Phosphate buffer: Acetonitrile) in ratio of 65:35 and obeyed linearity in the concentration range of 1- 150 ppm. The proposed method was statistically...
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Posted by admin on Apr 1, 2010 in |
Over the past decade, herbal and ayurvedic drugs have become a subject of world importance, with both medicinal and economical implications. A regular and widespread use of herbs throughout the world has increased serious concerns over their quality, safety and efficacy. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. In the present study we examined the antioxidant effects of ethanolic extract of leaves of Clerodendrum infortunatum Linn at various concentrations in the DPPH radical scavenging assay, FRAP assay (Ferric Reducing Antioxidant Power) and the Hydrogen peroxide radical scavenging assay. The results of the present study revealed that the plant extract has significant antioxidant activity and are encouraging for further assessment to elucidate the mechanism of action and to identify the bioactive compounds implicated in the antioxidant effect and the membrane-stability....
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Posted by admin on Apr 1, 2010 in |
Metoprolol tartrate which is used in the present study is widely used as antianginal properties. Oral bioavailability of metoprolol tartrate is around 40%. In the present work fast dissolving tablets of metoprolol tartrate have been prepared by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, % compressibility and Hausner’s ratio. The prepared tablets were evaluated for post compressional parameters such as hardness, friability, thickness, in-vitro dispersion time, wetting time, and water absorption ratio. The prepared tablets were characterized by DSC and FTIR studies. Stability studies were carried out as per ICH guidelines for three months. Effect of superdisintegrants [such as croscarmellose sodium, sodium starch glycolate, crospovidone, and Indion 414] on wetting time, in-vitro dispersion time and stability parameter has been studied. In-vitro dispersion time decreases with increase in concentration of indion 414 upto 9% then increases. Where as in-vitro dispersion time decreases with increase in the concentration of croscarmellose sodium and in-vitro dispersion time increases with increase in concentration of sodium starch glycolate....
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