Posted by admin on Oct 1, 2010 in |
The present communication deals with the laboratory studies carried out to determine the antihelmintic activity of Cymbopogon citratus leaves extracts against Pheritima posthuma. Methanolic and aqueous extracts were used as test solutions. Piperazine citrate was used as standard drug and normal saline as a control. Study involved the determination of time of paralysis as well as time of death of worms. The results revealed that methanolic extract of Cymbopogon citratus leaves have better antihelmintic activity than the aqueous extract of the same. Further studies including preparation of emulsion from the oils obtained from the leaves were also carried...
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Posted by admin on Oct 1, 2010 in |
Sphaeranthus indicus Linn (Asteraceae) is a common annual spreading herb found in rice field throughout India. Six crude extracts were prepared from the whole plant Sphaeranthus indicus using different solvents by cold maceration process. The extracts were subjected to screening to detect potential antimicrobial activity against S. aureus, B. substillus, P. Gentamycin and Nystatin as standard by cup plate agar diffusion method. The aim of our present study was to find out the antimicrobial activity of the different extracts of entire part including flower heads of Sphaeranthus indicus. The different extracts such as hexane, chloroform, ethyl acetate, ethanol, methanol and aqueous extract exhibits comparable antimicrobial activity with the...
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Posted by admin on Oct 1, 2010 in |
The mucoadhesive disks of various polymers were fabricated with objective of comparing the mucoadhesive strength and mucoretentability with the isolated DPP. The mucoadhesive polymers used in formulations were sodium carboxy methyl cellulose, carbopol (cp934), hydroxyl propyl methyl cellulose (HPMC K4M), and date palm fruit pulp polysaccharide (DPP). These formulations were characterized for physiochemical parameters, in vitro retention time, in vitro bioadhesive strength, Friability etc. The modified in vitro assembly was used to measure the mucoadhesive strength of disks with fresh goat and porc buccal mucosa as a model tissue. Mucoadhesive study showed that it possess a novel inbuilt significant mucoadhesive property therefore this biomaterial can serve as promising mucoadhesent for formulating the various transmucosal drug delivery...
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Posted by admin on Oct 1, 2010 in |
The plant Acacia leucophloea Roxb is reported to have great medicinal value in Indian medicine. The present study deals with the pharmacognostical investigation on stem bark of Acacia leucophloea. Pharmacognostical evaluation such as macroscopical and microscopical characters, ash value, moisture content and extractive values were carried out. ...
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Posted by admin on Oct 1, 2010 in |
The aim of the present investigation was to develop a novel gastro retentive dosage form of Ranitidine hydrochloride (RHCl) to achieve prolong gastric retention, increase drug bioavailability and to modulate the release of RHCl in the stomach, by using various ratios of HPMC E-15, a low-density grade polymer and it was cheaper and easily available along with Carbopol 934, as gel former. Sodium bicarbonate and citric acid were added as Effervescent agent. The tablets were prepared by wet granulation technique as 12 different formulation batches F1 to F12 depend on variable polymer ratios by using single punch hand operating machine, were evaluated for physical characteristics viz. hardness, swelling index, thickness, and weight variation. Further, tablets were evaluated for in vitro buoyancy time and in vitro release characteristics for 12 hr. Tablet achieved sufficient buoyancy due to the CO2-gas formation and their entrapment by polymeric gel membrane. The increased amount of a gas forming agent did not affect time to float but increased the drug release from the floating tablets...
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