Ketoprofen is a non-steroidal anti-inflammatory drug. Glucopyranoside Conjugates of Ketoprofen have been synthesized and evaluated for anti- inflammatory, analgesic and ulcerogenic activities. In vivo biological screening in mice and rats indicated that conjugates improved analgesic and anti-inflammatory activities with significantly reduced ulcerogenicity compared to the parent...
Read MoreThe study is aimed at development of Physico-chemical parameters and to investigate the active principle present in Chlorophytum borivilianum. Chlorophytum borivilianum San. and Fern. (Liliaceae) commonly known as Safed Musli is an important plant used against various disorders in indigenous systems of medicine, such as antioxidant, analgesic, and as a remedy for male impotence and to boost the immune system. This plant is to be considered as an endangered plant due to its potent use in many of the tribal areas in India and used widely in Traditional System of Medicine. Thus from extensive literature survey it was revealed that no reports were available on microscopic evaluation, standardization parameters and chemoprofile of Chlorophytum borivilianum to check the identity and purity of the drug. The present work embodies the investigations carried out to establish methods for quality control of drugs as per WHO guidelines: complete botanical evaluation which comprises of macroscopy, microscopy, physico-chemical parameters like Loss on Drying, Extractive values, Foaming index, Ash values and to investigate the phytochemical present...
Read MoreIn present study, in vitro methods were selected to test and compare the antioxidant activity at different levels involving formation and scavenging of free radical by extract of Butea monosperma flowers (EBMF). The total phenolic content of EBMF was found to be 19.09 mg (equivalent to gallic acid) per gram of extract. In addition, reducing power was found to be increase with the increasing concentration of extract. The extract exhibited concentration dependant radical scavenging activity in DPPH with IC50 value- 47. 2 µg/ml. All the above in vitro studies clearly indicate that the EBMF posses a significant antioxidant...
Read MoreAnti-inflammatory activity of the ethanolic extract of the Cissampelos pariera Linn leaves was studied in albino wistar rats using the carrageenan induced rat paw edema model. The ethanolic extract of Cissampelos pariera (400 mg/kg p.o.) inhibited carrageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indicated that the extract produced significant (P < 0.05) anti-inflammatory activity when compared with the standard drug indomethacin (10 mg/kg p. o.) and untreated...
Read MoreOfloxacin is a fluoroquinolone antibiotic considered to be a second-generation fluoroquinolone. Ofloxacin is administered by oral, intravenous or topical (eye and ear drop) route. It is used as antibacterial for the treatment of various diseases like chronic bronchitis, pneumonia, urethritis, cervicitis, urinary tract infections, prostatitis, uncomplicated urethral and cervical gonorrhea. Ofloxacin is a pale yellow or bright yellow, crystalline powder. It is slightly soluble in water, soluble in glacial acetic acid, slightly soluble or soluble in methylene chloride, slightly soluble in methanol. A simple Nanodrop spectrophotometric method was developed for the determination of Ofloxacin in pure and its pharmaceutical tablet dosage form. Ofloxacin exhibiting λ max at 296 nm in mobile phase (0.05 M Phosphate buffer: Acetonitrile) in ratio of 65:35 and obeyed linearity in the concentration range of 1- 150 ppm. The proposed method was statistically...
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