Posted by admin on Aug 15, 2010 in |
A simple, accurate, cost effective and reproducible spectrophotometric method has been developed for the estimation of Diphenhydramine Hydrochloride in soft gelatin capsule dosage form. For UV spectrophotometric method, maximum absorption was found at λmax 258nm.The percentage recovery of Diphenhydramine Hydrochloride ranged from (98.97 ± 0.2989) in capsule dosage form. The developed method was validated as per ICH guidelines with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 10-100μg/ml having line equation y = 0.016x – 0.018 with correlation coefficient of 0.9934. By treating the data statistically and by recovery study, results of study were...
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Posted by admin on Aug 15, 2010 in |
In this study, the anti-inflammatory effect of methanolic extract obtained from root tubers of plant Curculigo orchioides Gaertn. (Amaryllidaceae) was investigated. The effect of extract was studied in Carrageenan induced rat paw oedema. The extract at a dose of 200mg/kg and 400mg/kg was carried out for the investigation. The results indicate that methanolic extract, at the dose of 200mg/kg & 400mg/kg was found to have statically significant anti-inflammatory activity as compare to control. The percentage inhibition of inflammation was found higher at the dose of 400mg/kg body weight at 3rd hr as compare to 200mg/kg.The activity was compared with that of the standard drug, Diclofenac sodium (15mg/kg)....
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Posted by admin on Aug 15, 2010 in |
Despite recent success, many fast-dissolving tablets (FDTs) still face problems of low mechanical strength, poor mouth-feel, higher wetting and disintegration times. This research work aimed to overcome from these drawbacks. Attempts were made to prepare fast dissolving tablets by employing vacuum drying technique utilizing single and multi-volatile components. Analysis revealed that, formulation containing camphor and menthol as subliming agents yielded the best result in terms of dissolution rate (M7). Results also revealed that, all the formulations had enough mechanical strength, good mouth-feel and lesser wetting and disintegration time. Stability study indicates that upon storage disintegration and wetting time of tablets decreased significantly without losing their mechanical strength....
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Posted by admin on Aug 15, 2010 in |
Phytochemical and Gut motility activity of Ethanolic Extract of whole plant of Scutia Myrtina Kurz collected from Kolli Hills, Tamil Nadu was studied. Phytochemical studies revealed the presence of Alkaloids, Glycosides (Anthraquinone), Flavonoids and Tannins. For Gut Motility activity Extracts in concentration of 200mg/Kg and 400mg/Kg were studied in three animal models in comparison to Caster Oil and Glaxenna; (a) Gut motility activity in isolated Rat Intestine, (b) Propulsive Gut motility in mice & (c) Laxative activity in Mice. The Gut motility activity was assessed by different parameters depending on respective animal models. Caster Oil and Glaxenna were used as Standard drugs depending on the animal models. Gut motility in the test drug treated animals were found to be significant in all the models. Anthraquinone Glycosides present in the drug is probably responsible for the Gut motility...
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Posted by admin on Aug 15, 2010 in |
Cassia aungostifolia is a common herbaceous belongs to the family of Caesalpiniaceae. Seeds of plant contain gluco-mannose hence attempt to evaluate the seeds for suitability as tablet binder is considered and the present exploration repots the isolation of mucilage of Cassia aungostifolia seed. The DSC and FTIR thermograms of drug and mucilage indicated no chemical interaction. Phytochemical and Physiochemical characteristics of mucilage were studied which confirmed the mucilage nature. The mucilage was evaluated for its granulating and binding properties in compressed tablet using Diltiazem HCl as model drug. The granules prepared by mucilage were compared with xanthan gum, which was used as standard binder. The tablets had good physiochemical properties and the drug release was more than 95% within 2hr. It was observed that increasing the concentration of mucilage increases hardness and decreases the disintegration time. All the formulations were subjected to stability studies for three months as per ICH guidelines all four formulation showed stability with respect to release pattern and other parameters which confirm the use of...
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