Posted by admin on Jan 31, 2025 in |
Allergic conjunctivitis (AC) is a prevalent ocular condition characterized by inflammation of the conjunctiva due to allergen exposure, resulting in itching, redness, and discomfort. Traditional medicinal plants such as Ginkgo biloba and Aegle marmelos have been recognized for their potential anti-inflammatory and anti-allergic properties. In this study, we conducted an in-silico analysis to explore the therapeutic potential of phytochemicals derived from Ginkgo biloba and Aegle marmelos against AC. First, we compiled a list of phytochemicals in Ginkgo biloba and Aegle marmelos, focusing on compounds known for their anti-inflammatory and immunomodulatory activities. Molecular docking studies were performed to investigate the binding interactions between these phytochemicals and key proteins implicated in the pathogenesis of AC, including histamine receptors, inflammatory cytokines, and enzymes involved in the allergic response. Virtual screening techniques were employed to identify potential lead compounds with high binding affinities and favorable pharmacokinetic properties. Additionally, ADME/T properties were predicted to assess the bioavailability, metabolic stability, and potential toxicity of the selected phytochemicals. In-silico findings suggest that certain phytochemicals from Ginkgo...
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Posted by admin on Jan 31, 2025 in |
Liver is an important organ and a central one for many of the metabolic functions of the body, decomposition of toxic and waste substances, and disposal of harmful substances from the body. Liver illnesses are still the serious problem of human health. Canna indica commonly known as an Indian shot, extensively used as a nutritive agent & has a number of valuable pharmacological activities. People find its place in Ayurvedic Pharmacopoeia of India, but attempts have not made to describe the hepatoprotective activity of this plant. The present work emphasizes the comprehensive ethano-medicinal uses of Canna indica root to enlighten its phytochemical constituents and hepatoprotective activity of this plants. To authenticate the traditional medicinal claim of investigation has been undertaken to evaluate the hepatoprotective activities of Canna indica plant. Administration of paracetamol and different extracts of Canna indica showed no mortality or morbidity in the animals during the period of study. The values of AST, ALT, ALP, and total bilirubin were all substantially raised by paracetamol. Significant hepatoprotective effects...
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Posted by admin on Jan 31, 2025 in |
Background: Acute gastroenteritis is usually considered – a benign disease, remains a major cause of pediatric morbidity and mortality around the world. Materials and Methods: An observational cross-sectional study conducted in indoor / outdoor patient department of Pediatrics in Government Medical College and Rajindra Hospital, Patiala for 6 months. Demographic data and complete prescriptions of patients suffering from acute gastroenteritis (age >1month to 6 years) were collected and analyzed by using five World Health Organization Core prescribing indicators. Categorical data was analyzed by chi-square test and quantitative data was analyzed by descriptive method. Prevalence of disease was calculated. Results: In total 60 patients, male patients (58.33%) were found to be more infected than female patients (41.67%). In age group of 0-2 years more males 82.86%, and in age group of 2-5 years and 5-6 years more females i.e., 80% and 12%, respectively were found to be infected with acute gastroenteritis. Most prescribed class of drug was drugs acting on gastrointestinal tract (51.46%) followed by fluid & electrolytes (22.7%), antimicrobials...
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Posted by admin on Jan 31, 2025 in |
Head and Neck Squamous Cell Carcinoma (HNSC) is a fast-growing form of cancer. This cancer originates in the squamous cells of the mouth and throat and primarily affects individuals who engage in risky lifestyle choices such as tobacco and alcohol consumption. The poor prognosis and high mortality rate of HNSC underline the urgent need for extensive research and novel treatment approaches. This comprehensive study aims to determine the genetic and gene expression differences between male and female patients with Oral Squamous Cell Carcinoma (OSCC). It will also be examined whether differences in unique genes are common in both male and female patients. We used the Galaxy web server to conduct a study employing whole exome sequencing (WES) and RNA sequencing (RNA-Seq) data. The research we conduct requires accurate sample preparation that allows us to obtain useful insights. We found variations in the aligned reads within the WES data that provide insight into particular genetic variations associated with OSCC. At the same time, we discovered various gene expression patterns in...
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Posted by admin on Jan 31, 2025 in |
Aim: This study aimed to compare the analgesic efficacy of caudal ropivacaine and ketamine with ropivacaine and midazolam in paediatric patients undergoing infraumbilical surgery. Material and Methods: A study was conducted involving a group of 100 paediatric patients who underwent infraumbilical surgery. The study participants were divided into two groups: Group A received 1.0 ml/kg of 0.15% ropivacaine with 0.3 mg/kg of ketamine, while Group B received 1.0 ml/kg of 0.15% ropivacaine with 0.03 mg/kg of midazolam. The duration of the surgery, the duration of anaesthesia, the use of inhalation agents, and any complications were carefully documented. Results: The TTFAR for groups A and B were 14.5±3.50 hours and 12.26±4.12 hours, respectively. There was a significant difference in values between groups A and B (p≤0.05). The mean total fentanyl acetaminophen consumption in 24 hours was 101.79±79.14 mg for group A and 117.50±97.50 mg for group B. After the surgery, there was a noticeable difference in the FLACC pain scores between the two groups at various time intervals. Conclusion: The...
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