Posted by admin on Jul 31, 2022 in |
Worldwide antimicrobial resistance is a serious problem and differs from region to region. This study has designed the determination of the incidence and sensitivity pattern of Escherichia coli (E. coli) and discusses the general issues related to antimicrobial resistance. Prospective study was carried out between JAN to April 2020. Samples of urine, blood, pus and miscellaneous (fluids, swabs and sputum) were collected from indoor patients. The present antimicrobial susceptibility of E. coli, the study was performed in the Department of Microbiology Narayana Super-specialty Gurugram, Total of 315 samples were tested out, 97 samples showed growth on culture and out of 97 samples, 40 E. coli have isolated and tested antibiotics sensitivity, it has been demonstrated that different samples showing a significant amount of antimicrobials Sensitivity and resistance to different antibiotics (Table 2). Antimicrobials, namely Meropenem have shown sensitivity (65%), imipenem (60%), Colistin (70%). Thus, there is a need for the implementation of strong antimicrobial stewardship program and stop misuse of antibiotics with an instant effect. Our region’s present study...
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Posted by admin on Jul 31, 2022 in |
Background: Syzygium cumini (SC) usually acknowledged as Jamun. All components of the Jamun may keep used medicinally because of a wide range of diseases like cough, diabetes, dysentery and inflammation. Objectives: Present investigational on the anti-diabetic activity of the methanolic extract seeds of SC in STZ-induced Type I Diabetes in rats. Methods: Extracted SC was to be evaluated the toxicity as OECD 425 guidelines, and biochemical, hematological then gross pathological evaluation has been assessed. Type I diabetes has been triggered in Wistar rats via STZ 65mg/kg/b.w. I.P. During the experiment, Rat’s body weight and blood glucose level were monitored. At the end of the study, animals amongst complete groups were sacrificed, and biochemical parameters; Lipid profile, C-Peptide, HbA1c, Serum insulin, pancreatic insulin, and histology on the pancreas were performed. SC was also screened for pro-inflammatory cytokines viz., IL-1β, IL-6 and TNF-α had been performed via ELISA. Furthermore, Antioxidant Enzymes as SOD, CAT, LPO, and GSH were also performed. Results: The observed extract SC was proven safe among the toxicity...
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Posted by admin on Jul 31, 2022 in |
Alzheimer’s disease, the most frequent cause of dementia, is a major global health concern with enormous societal and individual ramifications. Some of the hallmarks linked with AD include a decrease in acetylcholine (ACh) levels in the synapse, the buildup of extracellular beta-amyloid plaques, and tau protein intraneuronal tangles. Low levels of ACh have been linked to memory and reasoning problems. Plaques may disrupt signal transmission from neuron to neuron, resulting in cell death, whereas tau tangles obstruct the passage of vitamins and other essential nutrients within neurons. The efficacy of an ethanolic extract of Origanum vulgare leaves (OVE) against scopolamine-induced Alzheimer’s disease in Wistar albino rats was investigated in this work. OVE was given to rats at doses of 100 mg/kg body weight, 200 mg/kg body weight, and 300 mg/kg body weight at a dose of 2.5 mg/kg. Morris water maze, Novel object recognition test, and Y-maze were used to examine anti-Alzheimer activity, as well as biochemical tests such as neurotransmitter Acetyl cholinesterase activity, catalase activity, malonyl dialdehyde and...
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Posted by admin on Jul 31, 2022 in |
The present research is intended for the formulation development, optimization, and in-vitro evaluation of bi-layer tablets containing Enalapril maleate, hydrochlorothiazide in the immediate release layer and Nifedipine in the sustained release layer based on GEMINEX technology. The impact of formulation variables such as combination of polymers and coating solution on the drug release was evaluated from the developed formulation. The prepared formulation blend was assessed for compressibility characteristics. The homogeneity of each API in a blend was tested by determining the %assay of individual drugs from different layers. Both the immediate and controlled release granules were formulated into bilayer tablets by the direct compression method. SEM analysis of bi-layered tablets was also performed. The mean drug content for all formulations was found to be within specified limits. The In-vitro dissolution studies can be performed at USP type II dissolution apparatus for coated tablets. The release of Enalapril maleate and hydrochlorothiazide from the immediate-release layer was found to be 99.2+0.8% and 99.5+1.1, and Nifedipine from the sustained release layer was...
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Posted by admin on Jul 31, 2022 in |
Diabetes Mellitus is a chronic metabolic disorder that has become increasingly evident, necessitating more stable and continuous therapeutic monitoring. Metformin Hydrochloride, being the primary treatment choice in type II Diabetes, presents certain limitations like improper GI absorption and the need for multiple dosing. Controlled drug delivery proves to be a better option in such conditions to provide an uninterrupted treatment. The present study is based on the development of oral controlled matrix tablets of Metformin. Plant-derived gums like Gum Okra, Gum Moringa, Gum Xanthan were extracted suitably and used as release controlling agents individually and in combination with Eudragit RL 100 in varying proportions. EC was employed to form a secondary backing layer. Thirteen formulations with polymers in different ratios were developed using the Wet granulation technique. The physicochemical properties of the prepared matrix tablets were found to be satisfactory. In-vitro release studies were performed in simulated media, 0.1 N HCl and Phosphate buffer, pH 6.8 and results have shown that formulation F11 containing Gum Moringa and Eudragit RL-100...
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