Posted by admin on Nov 30, 2025 in |
Introduction: Hypertension is a major global health challenge and a significant contributor to cardiovascular diseases and death. Calcium channel blockers (CCBs) are effective in managing various stages of hypertension. The aim of study was to compare the safety and effectiveness of amlodipine and cilnidipine in newly diagnosed patients of hypertension. Material and Methods: This prospective, randomized, open-label, parallel-group study was conducted at Guru Nanak Dev Hospital, Amritsar. Sixty newly diagnosed mild to moderate hypertensive patients were randomly assigned to two groups. Group A received amlodipine 5 mg, and Group B received cilnidipine 10 mg once daily for 12 weeks. Blood pressure, heart rate and biochemical parameters were recorded at baseline, 4, 8, and 12 weeks. Adverse events were monitored, and data was analysed. Observations: Baseline characteristics were largely similar in two groups, except total cholesterol, which differed significantly (p = 0.043). Both groups showed significant reduction in SBP and DBP over the 12-week period (p < 0.001), with no notable difference between two groups (p > 0.05). Heart rate...
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Posted by admin on Nov 30, 2025 in |
Background: Fungal infections, particularly dermatophytosis, affect nearly one-fourth of the global population, with Tinea cruris being prevalent in humid climates. Silver nanoparticles (AgNPs) exhibit strong antimicrobial particularly antifungal properties and may offer an effective textile-based solution. This study aimed to develop, characterize, and clinically evaluate nanosilver-infused antifungal undergarments to combat recurrent Tinea cruris. Methods: A 95% cotton and 5% elastane fabric blend was treated with a 0.3% nanosilver suspension using the exhaust method. Characterization involved scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) to assess nanoparticle deposition. Wash durability was evaluated over 30 cycles. Antimicrobial activity was assessed using AATCC 100:2019 for antibacterial efficacy against Staphylococcus aureus and Klebsiella pneumoniae and AATCC Part 3:2017 for antifungal activity against Candida albicans. A prospective, real-world evidence, experimental clinical study was conducted on 90 patients with recurrent tinea cruris who wore nanosilver-infused innerwear for twelve weeks alongside standard antifungal treatment. Clinical outcomes were assessed at four and twelve weeks. Results: SEM-EDX confirmed the successful deposition of AgNPs, while...
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Posted by admin on Nov 30, 2025 in |
The study was conducted to evaluate the hepatoprotective effect of ethyl acetate extract of Moringa oleifera leaves in D -galactosamine (D-GalN) induced hepatotoxicity in albino rats. The hepatoprotective effect of ethyl acetate extract of M. oleifera leaves at doses of 150mg/kg, 200mg/kg and 250 mg/kg body weight respectively per orally was evaluated by inducing hepatotoxicity with D-Galn at a dose of 300mg/kg body weight intraperitoneally and using Silymarin 100mg/kg per orally as the standard reference drug. The hepatoprotective activity was monitored biochemically by various biochemical assays (serum SGOT, SGPT, ALP, LDH, γGT, total and direct bilirubin) using a Sys 200 pro autoanalyzer and histopathological examinations of the collected liver were carried out. The extract exhibited significant (p < 0.05) hepatoprotective effect in a dose-dependent manner in D-GalN intoxicated albino rats. Standard drug, silymarin (100mg/kg) also significantly reversed the hepatotoxicity. The histopathological findings were supportive of the biochemical findings which highlighted the protective role of Moringa oleifera against hepatic injury induced by D-...
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Posted by admin on Nov 30, 2025 in |
The present study investigates the pharmacological potential of Rumex acetosa through a multidisciplinary approach involving phytochemical analysis, UV and IR spectroscopy, and in-silico modelling. Ethanolic extracts of the plant were subjected to qualitative phytochemical screening, revealing the presence of flavonoids, alkaloids, and anthraquinones compounds known for their therapeutic properties. UV spectroscopic analysis confirmed the presence of conjugated systems through distinct absorption maxima, while IR spectroscopy identified characteristic functional groups such as hydroxyl, carbonyl, and aromatic moieties. These findings suggest a rich bioactive phytochemical composition. To further explore potential mechanisms of action, molecular docking studies were performed using key bioactive constituents against protein targets implicated in diabetic neuropathy. The docking results demonstrated favourable binding affinities, particularly with proteins involved in oxidative stress and inflammatory pathways, indicating possible neuroprotective and antidiabetic effects. Collectively, the results support the ethnopharmacological relevance of Rumex acetosa, suggesting it holds significant promise for the management of diabetes and its neurological complications. This integrative study provides a scientific rationale for its traditional use and encourages further preclinical...
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Posted by admin on Nov 30, 2025 in |
Background: Drug utilization studies (DUS) assess the marketing, distribution, prescription, and use of drugs, emphasizing their medical, social, and economic impacts. In intensive care units (ICUs), rational drug use is essential due to the complexity of treatment and the risk of antimicrobial resistance. Aim: This study analyzes antimicrobial utilization patterns in the Medical ICU. Methods: A cross-sectional, quantitative observational study was conducted at the Medical ICU of Jawahar Lal Nehru Medical College, Ajmer, from November 2022 to December 2023. The study included 400 patients aged ≥18 years. Data on demographics, comorbidities, drug prescriptions, and adverse drug reactions (ADRs) were collected. The WHO Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology was used for drug classification and consumption analysis. Results: The most common age group was 61-75 years (26%), with a male predominance (58%). Hypertension (29.75%) and diabetes (23.75%) were the most prevalent comorbidities. Ceftriaxone (55.25%) was the most frequently prescribed antimicrobial, followed by Piperacillin + Tazobactam (19.25%). ADRs were observed in 44 cases (11%), with thrombophlebitis being the most common...
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