Posted by admin on Mar 31, 2025 in |
This study aimed to design and evaluate a thermoreversible, mucoadhesive intranasal gel formulation of Trazodone HCl for enhanced drug delivery to the brain. Pre-formulation processes involved characterization of the drug using UV spectroscopy, FTIR, and DSC techniques to confirm drug purity and compatibility with excipients. The nasal gel was formulated using Poloxamer 407 (19%) and Carbopol 934P (0.1% – 0.5%) through the cold method. The formulated gels were evaluated for pH, clarity, viscosity, mucoadhesive strength, in-vitro drug release, and ex vivo permeation across goat nasal mucosa. Gelation temperature was optimized to align with physiological nasal temperatures (32–34°C), and results demonstrated effective sol-to-gel transitions. Drug release studies revealed over 85% release from optimized formulation (A4) within 8 hours. Ex-vivo permeation studies confirmed significant drug absorption through the nasal membrane, with A4 exhibiting 78.45% cumulative drug release. Stability studies validated the formulations’ reliability, and no incompatibilities were observed between drug and excipients. This intranasal gel formulation represents a promising, non-invasive approach to improve the bioavailability and therapeutic efficacy of Trazodone HCl...
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Posted by admin on Mar 31, 2025 in |
Eryngium foetidum commonly known as cilantro or spiny coriander is a tropical perennial herb known for its distinctive aroma and medicinal properties. While it is mainly used as a culinary herb, it has long been valued in traditional medicine for a variety of health benefits. The present study was intended to analyse the phytochemicals present in the ethanolic extract of the leaf. Qualitative analysis has revealed the presence of various bioactive compounds and the major classes of phytochemicals typically found in Eryngium foetidum were flavonoids, tri-terpenoids, steroids, tannin, saponin, carbohydrate and phenol. Also, attempt has been made to isolate endophytic bacteria from Eryngium foetidium after performing controlled surface sterilization. The isolated organisms were marked as B1 and B2 and subjected to perform antibacterial and antifungal activities against important pathogenic strains viz; Staphylococcus aureus, Pseudomonas aeroginosa, E. coli, Klebsiella pneumonia & Aspergillus sp. The B1 isolate was however found to be effective with its substantial activities with zone of inhibitions of 18mm, 17mm, 15mm and 17mm respectively along with the...
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Posted by admin on Mar 31, 2025 in |
Introduction: The use of supplements in the fitness industry has experienced a notable surge due to the growing awareness of their potential health benefits. Fat burners, a popular type of supplement, are commonly employed to assist in weight loss. However, it is important to acknowledge that fat burners can have adverse effects on the body. Common side effects include increased heart rate, elevated blood pressure, sleep disturbances, restlessness, heightened anxiety, and digestive issues. They often contain ingredients like green tea extract, herbs, and minerals, which can enhance energy levels and speed up metabolism. Some fat burners also include stimulants like caffeine, ephedrine, and yohimbine, which can lead to additional problems like rapid heart rate, dehydration, and agitation. In certain cases, fat burners may even pose a risk to liver health. Objective: To ensure the safety and accuracy of fat burner supplements, a method known as RP-HPLC (Reversed Phase High-Performance Liquid Chromatography) was developed and validated according to the guidelines established by ICH of Technical Requirements for Pharmaceuticals for Human...
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Posted by admin on Mar 31, 2025 in |
The aim of the present work was to develop clindamycin phosphate-loaded nanosuspension lyophilized powder for axillary osmidrosis caused by bacterial activity in apocrine glands. The formulation prepared using the solvent/antisolvent method included Eudragit L100, PVP K30, and Tween 80. Optimization via central-composite design (CCD) yielded formulation with a particle size of 179 nm and viscosity of 1.35 cps. Characterization confirmed favorable sedimentation volume, drug content and zeta potential with SEM revealing a spherical and porous structure. Lyophilization improved stability and permeability, and in-vitro studies demonstrated 24-hour drug release. Antibacterial testing showed good efficacy against Staphylococcus aureus indicating potential of clindamycin nanosuspension as a promising topical delivery system with enhanced...
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Posted by admin on Mar 31, 2025 in |
Onychomycosis is a fungal infection of fingernails and toenails which accounts for majority of all nail disorders caused by Dermatophytes, Candida and Nondermatophytic Molds. Numerous Antifungal formulations are available in the market in the form of cream, ointment, lotion, powder, and solutions which require high concentration of active agents to be incorporated and have short residence time on the nail bed leading to inadequate penetration and lower efficacy. In the current study an effort is given to develop a superior alternative dosage form using essential oil as an antifungal agent. A medicated antifungal nail lacquer containing Tea Tree oil was developed using different penetration enhancers followed by evaluation of critical quality attributes. The formulation containing both Thioglycolic acid and salicylic acid at the concentration of 15% w/v exhibited favorable characteristics including non-volatile content, drug release, drug content, antimicrobial efficacy and permeability. The formulation containing both thioglycolic acid and salicylic acid exhibited prolonged release for around 12 hours with good permeability. Moreover, the nail lacquer forms a stable film immediately...
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