Posted by admin on May 31, 2022 in |
An ethnomedicinal exploration of weeds of Jhansi district, located in the state of Uttar Pradesh in India, has been carried out to identify and find out the use of weeds to treat different ailments. Folklore people living in remote areas do not have easy access to hospitals or medical facilities, so they depend on the plants and weeds present in their surroundings to treat various diseases or physical ailments. A survey was made to get the knowledge of medicinal values of weeds in three regions of Jhansi, and it was found that a total of 30 weeds was used at most by folklore people for their treatments. Identified weeds belonging to families Malvaceae, Asteraceae, Solanaceae, Euphorbiaceae, Poaceae, Amaranthaceae, Convolvulaceae, and Ceasalpinaceae, etc. were found to treat various ailments like fever, cough, flu, nausea, skin diseases, body ache, and overall weeds were also known to increase the immunity of the body. Although there is literature known about the uses of weeds or other plants, it is still required more to...
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Posted by admin on Apr 30, 2022 in |
Context: Ayurveda emphasizes applying herbal, metallic, mineral, and herbo-mineral preparations in therapeutics. Trivanga Bhasma (TB) is a potential trimetallic (Tin, Lead & Zinc) compound formulation widely used in routine Ayurvedic practice to treat several chronic ailments. Objective: To elucidate the toxicity profile of TB by oral administration in wistar albino rats to ascertain the safety aspects. Method: TB was administered in possible higher doses such as TED (Therapeutic Equivalent Dose), TED × 2 (2 times the Therapeutic Equivalent Dose), TED × 5 (5 times the Therapeutic Equivalent Dose) and TED × 10 (10 times the Therapeutic Equivalent Dose) for 28 days. The effect was assessed on ponderal changes, biochemical parameters, histopathology, and tissue analysis. Results: Results showed that TB did not induce any toxicity at TED, TED × 2, TED × 5; whereas histopathology and tissue analysis of very higher dose TED × 10 exhibited toxicity in the liver & kidney. Conclusion: The drug, however, at a dose of TEDx10 showed mild undesirable changes in the liver & kidney;...
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Posted by admin on Apr 30, 2022 in |
In previous studies, it has been shown that the activities of the glycolysis cycle enzyme are significantly altered with changes in kinetic attributes of hexokinase, phosphorfructokinase and lactate dehydrogenase. Moreover, the kinetic parameters of the terminal enzyme lactate dehydrogenase also changed significantly. In view of these observed changes, it was of interest to know if and how the flux of intermediates of the glycolytic pathway was also affected. With this objective, a simple, rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been developed for quantification of five important glycolysis intermediates of rate-limiting steps [viz. glucose-6-phosphate (G-6-P), fructose-6-phosphate (F-6-P), fructose-1,6-bis-phosphate (FBP), 3-phosphoglyceric acid (3PGA), and pyruvate in human erythrocytes. Liquid chromatography was performed using Supelco Ascentis Express RP amide (250 mm × 4.6 mm, 5µm) column with mobile phase, 10mM ammonium acetate in water and acetonitrile. The detection of metabolites was carried out by tandem mass spectrometry. In erythrocytes from Type 2 diabetic subjects, there was a significant increase in intracellular concentrations of G-6-P and 3-PGA, with a...
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Posted by admin on Apr 30, 2022 in |
Parkinson’s disease is a chronic progressive neuro-degenerative disease caused by selective degeneration of dopaminergic neurons in the dense part of the substantia nigra pars compacta. It is characterized by motor and non-motor symptoms, especially the gradual reduction of postural symptoms, instability, tremor and memory impairment, local neuron loss, which mainly occurs in the substantia nigra. The current study evaluated the effects of non-steroidal anti-inflammatory drugs on reserpine-induced Parkinsonism experimental model. Subcutaneous injection of reserpine (1 mg/kg) was given to all rats for 5 days to induce Parkinson’s like symptoms; syndopa (10 mg/kg) was used as standard, and aspirin (60 mg/kg), celecoxib (20 mg/kg) and Indomethacin (20 mg/kg) were given orally and after 60 min of reserpine were administered. Behavioural and neurochemical parameter assays were done for dopamine, acetylcholinesterase, lipid peroxidation and other antioxidant enzymes. Our results showed reserpine significantly induced locomotor deficits and oxidation in the brain in a period of 5 days. Celecoxib, aspirin and Indomethacin showed significant improvement in locomotor behaviour and showed neuroprotective activity by reducing...
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Posted by admin on Apr 30, 2022 in |
In the recent past, adulteration of herbal products has increased rapidly, and today it is a global problem. Synthetic Phosphodiesterase type 5 inhibitors are the main adulterants in herbal medicine used for erectile dysfunction. The present study evaluated the herbal medicines used as sex enhancers in Nairobi County, Kenya, for adulteration with Phosphodiesterase type 5 inhibitors (sildenafil, tadalafil, and vardenafil). The products were purchased from health stores in Nairobi County. Samples were screened for adulteration with sildenafil, tadalafil, and vardenafil using HPTLC. Quantification was done by integration of sample chromatograms against standard chromatograms. The samples analyzed, 33.5% were adulterated. All the adulterated samples were imported, and none of the locally manufactured samples were found adulterated. The study revealed that samples from China/Hong Kong had the largest number 14 (53.85%) of the adulterated samples. These findings were in agreement with previous studies. A number of samples (32.5%) samples studied were adulterated. Sixty percent (60%) of adulterated samples contained sildenafil, while a few samples had either tadalafil, vardenafil or the...
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